NCT06608433

Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function

Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function - the PIANO Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the effects of a single dose of the glucagon-like 1 receptor agonist semaglutdie/Rybelsus on the hypothalamo-pituitary-adrenal axis, thus cortisol levels and other stresshormones in healthy males.

Conditions

• Healthy Volunteer Study
• HPA
• Cortisol Deficiency
• Adrenal Insufficiency

Interventions

Type	Name	Description
DRUG	semaglutide	semaglutide/Rybelsus will be administered as a single oral dose
DRUG	Placebo	Placebo pills will be administered as a single oral dose

Timeline

• Start date: 2025-01-16
• Primary completion: 2025-10-31
• Completion: 2025-11-30
• First posted: 2024-09-23
• Last updated: 2026-02-11

Locations

1 site across 1 country: Switzerland