NCT00575341

Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency

Dehydroepiandrosterone(DHEA) Substitution in Adolescent and Young Women With Central Adrenal Insufficiency. A Multicenter, Randomised Double Blind Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University Hospital Tuebingen · Academic / Other
• Sex: Female
• Age: 13 Years – 26 Years
• Healthy volunteers: Not accepted

Summary

30 adolescent girls and young women between 13 and 26 years with central adrenal insufficiency and a grand shortage of DHEA are recruit. The clinical trial is double-blind to show that the substitution of the hormone DHEA stimulates secondary hair growth, enhances well being and mood of the patients. It should also normalize the serum content of DHEA, aldosterone and testosterone.

Detailed description

30 adolescent girls and young women between 13 and 26 years with central adrenal insufficiency and a grand shortage of DHEA are recruit. After randomization they either get DHEA or placebo for 12 months daily. The clinical trial is double-blind to show that the substitution of the hormone DHEA stimulates secondary hair growth, enhances well being and mood of the patients. It should also normalize the serum content of DHEA, aldosterone and testosterone.

Conditions

• Adrenal Insufficiency

Interventions

Type	Name	Description
DRUG	Dehydroepiandrosterone	25 mg DHEA, oral, once daily
DRUG	placebo	placebo, oral, once daily

Timeline

• Start date: 2003-10-01
• Completion: 2007-04-01
• First posted: 2007-12-18
• Last updated: 2007-12-18

Locations

4 sites across 1 country: Germany