| Not Yet Recruiting | Adiposity Distribution in Acute Respiratory Failure NCT07019987 | Maurizio F. Cereda, MD | N/A |
| Not Yet Recruiting | Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure NCT07463885 | Oslo University Hospital | N/A |
| Not Yet Recruiting | Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients NCT07452406 | Rush University Medical Center | N/A |
| Not Yet Recruiting | Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure NCT07460427 | Prof RWABIHAMA Jean Paul | N/A |
| Not Yet Recruiting | Early Biological and Mechanical Profiling in Sepsis-Associated ARDS NCT07281911 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Recruiting | IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure NCT07189078 | University Hospital, Angers | N/A |
| Not Yet Recruiting | Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure NCT07175194 | Istituto Clinico Humanitas | — |
| Recruiting | Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respirato NCT07334379 | Lorenzo delSorbo | Phase 2 |
| Recruiting | Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation NCT06921655 | Centre for Medical Sciences | N/A |
| Recruiting | PEEP-induced Effects on Respiratory dRivE and EFfort NCT07203781 | Radboud University Medical Center | N/A |
| Enrolling By Invitation | Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure NCT06938217 | Institute for Extracorporeal Life Support | N/A |
| Recruiting | Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumo NCT06931938 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Active Not Recruiting | Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure NCT07178483 | Hospital Universitari de Bellvitge | — |
| Active Not Recruiting | Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure NCT06815523 | Jesus Villar | — |
| Recruiting | Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxyge NCT06795971 | Southeast University, China | N/A |
| Recruiting | EIT-Guided Ventilator Settings in AHRF NCT06936618 | Mahidol University | N/A |
| Recruiting | Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation NCT06494085 | Unity Health Toronto | — |
| Recruiting | Early Switch from Controlled to Assisted Ventilation NCT06438198 | Erasmus Medical Center | N/A |
| Recruiting | Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Pat NCT06501118 | University of Colorado, Denver | N/A |
| Recruiting | Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout. NCT06007495 | Fisher and Paykel Healthcare | N/A |
| Recruiting | Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT) NCT06374589 | Başakşehir Çam & Sakura City Hospital | N/A |
| Active Not Recruiting | Machine Learning Model to Predict Outcome in Acute Hypoxemic Respiratory Failure NCT06333002 | Dr. Negrin University Hospital | — |
| Recruiting | Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure NCT05675345 | Columbia University | N/A |
| Recruiting | Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care NCT06104956 | University Hospital, Tours | N/A |
| Unknown | Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure NCT06204276 | Siriraj Hospital | N/A |
| Completed | Physiology of Helmet vs. Facemask Noninvasive Ventilation NCT06210386 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Unknown | Impact of End-tidal Oxygen Monitoring During Preoxygenation Before Intubation for Acute Hypoxemic Respiratory NCT06198504 | University Hospital, Grenoble | N/A |
| Unknown | Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prosp NCT06064409 | Yonsei University | — |
| Withdrawn | Comparison Physiological Effects According to Preoxygenation Method Using EIT NCT05962073 | Samsung Medical Center | N/A |
| Unknown | Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory NCT06042036 | University of Sao Paulo General Hospital | — |
| Active Not Recruiting | Assessment of PaO2/FiO2 Ratio Pre and POst INTubation NCT05853068 | Dr. Negrin University Hospital | — |
| Completed | Predictors of HFNC Failure in Patients With AHRF Using Echocardiography Parameters NCT06096363 | Queen Mary Hospital, Hong Kong | — |
| Completed | Predictors of HFNC Failure in Patients With AHRF Using Diaphragm Ultrasound NCT06096376 | Queen Mary Hospital, Hong Kong | — |
| Completed | Modified HFNC Therapy for ARF Patients Undergoing Flexible Bronchoscopy NCT05759832 | Beijing Chao Yang Hospital | N/A |
| Completed | Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure NCT05465083 | University Health Network, Toronto | N/A |
| Unknown | High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure. NCT05499039 | Assiut University | N/A |
| Completed | A Novel Index to Predict the Failure of High-flow Nasal Cannula in Patients with Acute Hypoxemic Respiratory F NCT05549882 | Southeast University, China | — |
| Completed | Strategies for Anticoagulation During Venovenous ECMO NCT04997265 | Vanderbilt University Medical Center | N/A |
| Recruiting | Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study NCT05196074 | Lorenzo delSorbo | — |
| Active Not Recruiting | HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT NCT05078034 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Awake Prone Positioning in Moderate to Severe COVID-19 NCT05083130 | Oxford University Clinical Research Unit, Vietnam | N/A |
| Recruiting | EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure NCT05150483 | Evangelismos Hospital | — |
| Completed | Intubation Prediction in COVID-19 Patients Treated With Awake Prone Positioning NCT05060926 | University of Lausanne Hospitals | — |
| Completed | Respiratory Mechanics Assessment During Assisted Mechanical Ventilation NCT05203536 | University of Milano Bicocca | — |
| Recruiting | Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions NCT04545242 | Dr. Negrin University Hospital | Phase 4 |
| Completed | Helmet Non-Invasive Ventilation for COVID-19 Patients NCT04477668 | King Abdullah International Medical Research Center | N/A |
| Completed | Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure NCT04741659 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Recruiting | ROX Index for the Timing of Intubation in Nasal High Flow NCT04707729 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Terminated | Early Versus Delayed Intubation of Patients With COVID-19 NCT04632043 | Evangelismos Hospital | N/A |
| Completed | Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome (ARDS) NCT04581811 | University of Alabama at Birmingham | N/A |
| Completed | Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respira NCT04570384 | Asklepion Pharmaceuticals, LLC | Phase 2 |
| Completed | Comparing Closed-loop FiO2 Controller With Conventional Control of FiO2 NCT04568642 | Dr. Behcet Uz Children's Hospital | N/A |
| Completed | High-Flow Nasal Cannula in Severe COVID-19 With Acute Hypoxemic Respiratory Failure. NCT04609462 | Fundacion Clinica Valle del Lili | N/A |
| Terminated | Helmet CPAP Versus HFNC in COVID-19 NCT04395807 | Lund University | N/A |
| Unknown | Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia NCT04344730 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Predictive Model for High-Flow Nasal Cannula Failure in COVID-19-related Acute Hypoxemic Respiratory Failure B NCT06695442 | Hospital del Mar Research Institute (IMIM) | — |
| Unknown | Impact of Current Volume Under High-rate Nasal Oxygen Therapy During Acute Hypoxemic Respiratory Failure de No NCT03919331 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | ATC vs PSV for Weaning in Patients With Respiratory Failure NCT07238140 | Ain Shams University | N/A |
| Completed | Weaning From Nasal High Flow Therapy NCT05210881 | Hôpital Louis Mourier | — |
| Recruiting | The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU NCT03642002 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Automated Analysis of EIT Data for PEEP Setting NCT03653806 | Maastricht University Medical Center | — |
| Unknown | Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS Patients NCT03513809 | Pontificia Universidad Catolica de Chile | — |
| Unknown | Incidence of Dyssynchronies in Early ARDS NCT03447288 | Unity Health Toronto | — |
| Completed | Effectiveness of High Flow Oxygen Therapy in Patients With Hematologic Malignancy Acute Hypoxemic Respiratory NCT03133520 | Kursat Gundogan | N/A |
| Completed | Benefits of Optiflow® Device for Preoxygenation Before Intubation in Acute Hypoxemic Respiratory Failure : The NCT01747109 | Nantes University Hospital | N/A |
| Withdrawn | Noninvasive Positive Pressure Ventilation for Early Extubation of Acute Hypoxemic Respiratory Failure NCT01151501 | Beijing Chao Yang Hospital | N/A |
| Unknown | Comparison Between High-flow Nasal Cannula System and Non-invasive Ventilation in Acute Hypoxemic Respiratory NCT01166256 | Asan Medical Center | Phase 2 / Phase 3 |
| Completed | Lucinactant for Treatment of Acute Hypoxemic Respiratory Failure in Children up to Two Years Old NCT00578734 | Windtree Therapeutics | Phase 2 |
| Unknown | Helmet CPAP vs Venturi O2 to Treat Early ALI/ARDS NCT00342368 | Catholic University of the Sacred Heart | N/A |
| Completed | High-Frequency Oscillatory Ventilation Associated With Inhaled Nitric Oxide in Children NCT00924846 | UPECLIN HC FM Botucatu Unesp | Phase 3 |
| Terminated | Efects of Noninvasive Mechanical Ventilation and Conventional Mechanical Ventilation in Patients With Severe C NCT00523497 | Hospital Privado del Sur | N/A |