NCT04741659

Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure

Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure Receiving Non-invasive Respiratory Supports: a Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Protective ventilation can be difficult to achieve during noninvasive ventilation for "de novo"acute hypoxemic respiratory failure (i.e., not due to exacerbation of chronic lung disease or cardiac failure).Recent data suggest patient self-inflicted lung injury (P-SILI) as a possible mechanism aggravating lung damage in these patients. The aim of this study is evaluate the tidal volume, measured by respiratory inductance plethysmography, in patients receiving different non invasive respiratory support.

Conditions

• Acute Hypoxemic Respiratory Failure

Interventions

Type	Name	Description
DEVICE	Ventimask	The patients will be asked to breathe spontaneously using their actual low oxygen flow
DEVICE	High Flow Nasal cannula (HFNC)	The patients will be asked to breathe using high flow nasal cannula (HFNC). Air flow will set up to 60 l/m, temperature according to patient's comfort and FiO2 in order to obtain SpO2 values \>/= 92%
DEVICE	Helmet CPAP	The patients will be asked to breathe with Helmet. CPAP will set at 10 cmH2O and FiO2 in order to obtain SpO2 values \>/= 92%
DEVICE	Non Invasive Ventilation (NIV)	the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface

Timeline

• Start date: 2021-01-20
• Primary completion: 2021-03-31
• Completion: 2021-07-30
• First posted: 2021-02-05
• Last updated: 2021-11-09

Locations

1 site across 1 country: Italy