NCT06096363

Predictors of HFNC Failure in Patients With AHRF Using Echocardiography Parameters

Predictors of High-Flow Nasal Cannula Failure (HFNC) in Patients With Acute Hypoxemic Respiratory Failure (AHRF) Using Echocardiography Parameters

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: Queen Mary Hospital, Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Right ventricular dysfunction (RVD) and right ventricular-pulmonary arterial (RV-PA) uncoupling detected by transthoracic echocardiography (TTE) in acute respiratory distress syndrome (ARDS) are associated with poor survival. Early detection of RVD and RV-PA uncoupling in patients with acute hypoxemic respiratory failure (AHRF) may be indicative of worsening and decompensating pulmonary condition which may require escalation of respiratory support. The use of TTE parameters in predicting high-flow nasal cannula (HFNC) failure has not been previously studied. The objective of this study is to identify predictors of HFNC failure by TTE and to compare its performance with the well-established ROX index.

Conditions

• Acute Hypoxemic Respiratory Failure

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transthoracic Echocardiography	Transthoracic Echocardiography to look for evidence of right ventricular (RV) dysfunction and right ventricular-pulmonary arterial (RV-PA) uncoupling.

Timeline

• Start date: 2023-04-28
• Primary completion: 2024-06-26
• Completion: 2024-09-01
• First posted: 2023-10-23
• Last updated: 2024-10-16

Locations

1 site across 1 country: Hong Kong