| Recruiting | Add-on Diuretics in Acute Decompensated Heart Failure NCT07372040 | Tanta University | Phase 2 |
| Not Yet Recruiting | Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure NCT07018297 | University of Texas Southwestern Medical Center | Phase 3 |
| Withdrawn | PREcision meDICine in Treatment in CardioVascular Disease NCT07369141 | Maastricht University Medical Center | N/A |
| Withdrawn | Cardiac Perfusion and Metabolism With [11C] Acetate PET/CT is Associated With Hematopoietic System Activation NCT03924102 | University of Alabama at Birmingham | Phase 1 |
| Recruiting | Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patien NCT07199088 | University of Health Sciences Lahore | N/A |
| Completed | Effects of In-Hospital Cardiac Rehabilitation and Manual Lymphatic Drainage in Acute Decompensated Heart Failu NCT07095764 | Izmir Bakircay University | N/A |
| Recruiting | Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G2 NCT06898515 | Reprieve Cardiovascular, Inc | Phase 3 |
| Recruiting | Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations NCT03951467 | Hospices Civils de Lyon | N/A |
| Not Yet Recruiting | Naturally Controlled Decongestion Using Renal Independent System in ADHF Patients, a European Registry NCT06401109 | AquaPass Medical Ltd. | N/A |
| Active Not Recruiting | IC14 for Treatment of Acute Decompensated Heart Failure NCT06556810 | Implicit Bioscience | Phase 1 / Phase 2 |
| Recruiting | Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure NCT06714409 | Oslo University Hospital | N/A |
| Recruiting | Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients NCT06535529 | Helwan University | Phase 3 |
| Not Yet Recruiting | Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistanc NCT06174623 | Puzzle Medical Devices Inc. | N/A |
| Completed | DORAYA-HF OUS Assessment of the Doraya Catheter for the Treatment of ADHF Patients With Insufficient Response NCT05876078 | Revamp Medical Ltd. | N/A |
| Recruiting | Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Vol NCT06414759 | Cairo University | Phase 4 |
| Completed | EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System ( NCT06362668 | Reprieve Cardiovascular, Inc | N/A |
| Recruiting | Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes NCT06475105 | Universitas Diponegoro | Phase 4 |
| Not Yet Recruiting | S-ADHF：Sarcopenia in Patients With ADHF NCT06298825 | Guangdong Provincial People's Hospital | — |
| Recruiting | Reprieve System Pilot Study NCT06272734 | Reprieve Cardiovascular, Inc | N/A |
| Completed | A Study to Assess Multidomain Endpoints of an ECG Patch NCT06243029 | AstraZeneca | — |
| Recruiting | The Association Between Visual Echocardiographic Scoring System and Clinical Outcomes in Patient With Acute De NCT06586008 | Universitas Diponegoro | — |
| Recruiting | EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF NCT06161987 | Guangdong Provincial People's Hospital | N/A |
| Recruiting | Mobile Education System to Improve Disease Knowledge, Self-efficacy and Quality of Life in Patients With Heart NCT06161649 | Chang Gung Memorial Hospital | N/A |
| Terminated | The Hemodynamic Effects of SGLT2i in Acute Decompensated Heart Failure NCT05346653 | University of Chicago | Phase 4 |
| Active Not Recruiting | Pharmacokinetics of Bisoprolol and SGLT2i in Acutely Decompensated Heart Failure NCT06453577 | Universität des Saarlandes | — |
| Recruiting | Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular Disease NCT06081205 | University Hospital, Ioannina | — |
| Recruiting | Adherence to Medication in Patients With Acute Decompensated Heart Failure NCT06459115 | Universität des Saarlandes | — |
| Unknown | Inspiratory Muscle Training in Acute Decompensated Heart Failure NCT04834336 | Dokuz Eylul University | N/A |
| Recruiting | Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF NCT05759806 | Nephronyx LTD | N/A |
| Active Not Recruiting | DORAYA-HF Early Feasibility Study NCT05206422 | Revamp Medical Inc. | N/A |
| Recruiting | Change in Stroke Volume Index After Diuresis for Patients With Decompensated Heart Failure NCT05240651 | NYU Langone Health | — |
| Completed | Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management S NCT05174312 | Reprieve Cardiovascular, Inc | N/A |
| Completed | Short-term Mortality Prediction by the SOFA Score in Acute Decompensated Heart Failure NCT06354426 | Hanoi Heart Hospital | — |
| Completed | The STIM-ADHF Study NCT05313438 | Cardionomic Inc. | N/A |
| Completed | Evaluation of Blood Volume Analysis- Guided Management of Decompensated Heart Failure NCT04855097 | Daxor Corporation | N/A |
| Active Not Recruiting | Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study NCT05291884 | Abiomed Inc. | N/A |
| Unknown | Empagliflozin and Dapagliflozin in Patients Hospitalized for Acute Decompensated Heart Failure NCT05776043 | Medical University of Warsaw | Phase 3 |
| Completed | Readily Available Urinary Sodium Analysis in Patients With Acute Decompensated Heart Failure NCT06278792 | Ziekenhuis Oost-Limburg | N/A |
| Completed | Use of ΔIVC for Early Diagnosis of AHF in AECOPD NCT05327374 | University of Monastir | — |
| Completed | DR REGISTRY: Prospective Observational Study of ADHF Patients With Insufficient Response to Diuretics NCT04877652 | Revamp Medical Ltd. | — |
| Completed | Motivational Enhancement - Acute Decompensated Heart Failure and OSA NCT04752462 | The Cleveland Clinic | N/A |
| Completed | Cardionomic STOP-ADHF Study NCT04814134 | Cardionomic Inc. | N/A |
| Completed | Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart F NCT06003972 | Hadassah Medical Organization | Phase 2 |
| Completed | Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart Failure NCT04318093 | Bristol-Myers Squibb | Phase 2 |
| Completed | SURPASS Impella 5.5 Study NCT05100836 | Abiomed Inc. | — |
| Withdrawn | HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trial NCT04391231 | Cedars-Sinai Medical Center | Phase 4 |
| Terminated | Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLS NCT04158674 | Centre Hospitalier Universitaire Dijon | Phase 3 |
| Terminated | A Feasibility Study on Ultrafiltration and Blood Volume Measurements NCT04241718 | Nuwellis, Inc. | N/A |
| Completed | Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure NCT04049045 | Christian Schulze | Phase 2 |
| Unknown | Does Ultrasound Assessment for Extravascular Lung Water and IVC Measurement Affect Outcomes in Inpatient Heart NCT04436718 | Riverside University Health System Medical Center | N/A |
| Withdrawn | Use of POC Pocket Ultrasound in the Estimation of Left and Right Atrial Pressures NCT03897647 | Montefiore Medical Center | N/A |
| Completed | SVC Occlusion in Subjects With Acute Decompensated Heart Failure NCT03836079 | Abiomed Inc. | N/A |
| Unknown | Exploring Diuretics Effective Management in Acute Decompensated Heart Failure, EDEMA Trial NCT03863626 | Cairo University | N/A |
| Unknown | Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Ac NCT05807152 | Centro Cardiologico Monzino | N/A |
| Completed | RAAS Optimization for Acute CHF Patients NCT03695120 | University of Florida | N/A |
| Unknown | Evaluate the Efficacy and Safety of Short-term Administration of SIMDAX NCT03555123 | Yooyoung Pharmaceutical Co., Ltd. | Phase 3 |
| Completed | Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR) NCT03505788 | Ziekenhuis Oost-Limburg | Phase 4 |
| Unknown | Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure NCT05298098 | University of Monastir | N/A |
| Completed | Reducing Readmission for Frail Elderly Patients With Decompensated Heart Failure NCT03246035 | Jewish General Hospital | N/A |
| Completed | Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart Failure NCT04471610 | Prof. Dr. Jörg Leuppi | N/A |
| Completed | A Study to Evaluate Lung Ultrasound as a Method to Measure Changes in Extravascular Lung Water Induced by Posi NCT03146754 | University of Pennsylvania | N/A |
| Completed | Future Patient - Telerehabilitation of Heart Failure Patients NCT03388918 | Aalborg University | N/A |
| Completed | High-dose Aldosterone Antagonist for Acute Decompensated Heart Failure NCT02823626 | The University of Texas Health Science Center at San Antonio | — |
| Recruiting | Low Level Tragus Stimulation in Acute Decompensated Heart Failure NCT02898181 | University of Oklahoma | N/A |
| Withdrawn | A Study to Investigate the Safety and Efficacy of a Novel Furosemide Regimen NCT02721511 | Todd M Koelling, MD | Phase 1 / Phase 2 |
| Completed | The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure NCT02617446 | Windtree Therapeutics | Phase 2 |
| Terminated | Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure (MELT-HF)--A Single Center Pilot Stud NCT02620384 | Aultman Health Foundation | Phase 3 |
| Completed | Effect of Providing Education and Patient's Inferior Vena Cava Ultrasound Images on Adherence to a Heart Failu NCT03488979 | Johns Hopkins University | — |
| Completed | Role of USCOM in Adult Patients With Heart Failure NCT02289508 | Chinese University of Hong Kong | — |
| Completed | A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients NCT02196038 | Wake Forest University Health Sciences | N/A |
| Completed | Evaluation of Cardiopulmonary Diseases by Ultrasound NCT02248831 | Echosense Ltd. | N/A |
| Withdrawn | Combination Diuretic Therapy for Acute Decompensated Heart Failure NCT05840536 | Ochsner Health System | Phase 4 |
| Withdrawn | Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure NCT05633758 | Scripps Health | Phase 2 |
| Terminated | Cardiovascular Improvements With MV ASV Therapy in Heart Failure NCT01953874 | ResMed | N/A |
| Completed | A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure NCT01966601 | Trevena Inc. | Phase 2 |
| Unknown | Gas Exchange for Predicting Hospital Heart Failure Readmissions NCT01960218 | Shape Medical Systems, Inc. | — |
| Unknown | Bedside Sleep Medicine NCT01924507 | Associação Fundo de Incentivo à Pesquisa | N/A |
| Completed | Tolvaptan/Ultrafiltration in the Treatment of Acute Heart Failure NCT01863511 | The Christ Hospital | Phase 4 |
| Suspended | Adaptive Servo Ventilation (ASV) in Heart Failure NCT02440971 | St Vincent's University Hospital, Ireland | — |
| Completed | Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure NCT01661634 | Cardiorentis | Phase 3 |
| Completed | REducing 30-day ADMIssions in posT-discharge Subjects (READMIT) NCT01574144 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Completed | Biomonitoring and Cardiorenal Syndrome in Heart Failure(BIONICS-HF) Trial NCT01570153 | Massachusetts General Hospital | — |
| Terminated | Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics NCT01457053 | University of Cincinnati | N/A |
| Completed | Prognostic Factors of Patients With ADHF NCT04390919 | Chongqing Medical University | — |
| Completed | Heart Failure (HF) Outpatient Monitoring Evaluation (HOME) Study NCT01347567 | Alere San Diego | N/A |
| Completed | Registry (Prospective Cohort) for Heart Failure in Korea (KorAHF) NCT01389843 | Byung-Hee Oh | — |
| Terminated | REWORD-HF REverse WOrsening Renal Function in Decompensated Heart Failure NCT01140399 | Niguarda Hospital | Phase 4 |
| Completed | A Comparison of Recombinant Human Brain Natriuretic Peptide and Dobutamine NCT01837849 | Nantong University | — |
| Completed | The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute NCT01971944 | University of North Carolina, Chapel Hill | — |
| Completed | Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study NCT01291836 | Alere San Diego | — |
| Terminated | Usefulness of Lung Ultrasound in Ambulatory Management of Patients With Chronic Heart Failure NCT03262571 | IRCCS San Raffaele | Phase 3 |
| Completed | Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltrati NCT01138683 | University Hospital, Ghent | Phase 3 |
| Terminated | Dopamine in Acute Decompensated Heart Failure II NCT01060293 | Larissa University Hospital | Phase 4 |
| Completed | Study to Assess the Safety and Efficacy of CD-NP in the Treatment of Patients With Acute Decompensated Heart F NCT00839007 | Nile Therapeutics | Phase 2 |
| Completed | Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in NCT00894387 | Novartis Pharmaceuticals | Phase 3 |
| Terminated | Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure NCT00843986 | Cumberland Pharmaceuticals | Phase 3 |
| Terminated | Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart F NCT00904488 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely D NCT00693745 | Abbott RDx Cardiometabolic | — |
| Completed | Study to Assess Hemodynamic Effects, Safety and Tolerability of Chimeric Natriuretic Peptide (CD-NP) in Patien NCT00699712 | Nile Therapeutics | Phase 2 |
| Completed | Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therap NCT00842023 | Western University of Health Sciences | Phase 4 |
| Recruiting | Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure NCT00762008 | UConn Health | — |