NCT01060293

Dopamine in Acute Decompensated Heart Failure II

Comparison of High-dose Furosemide, Low-dose Furosemide, and the Combination of Low-dose Furosemide and Low-dose Dopamine in Patients With Acute Decompensated Heart Failure

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 161 (actual)
• Sponsor: Larissa University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare the effects of 1) high-dose furosemide, 2) low-dose furosemide, and 3) low-dose furosemide combined with low-dose dopamine on diuresis, clinical status, renal function, electrolyte balance, length of stay, and 60-day post-discharge outcomes in patients hospitalized with acute decompensated heart failure.

Detailed description

The aim of this study is to compare the effects of: 1. high-dose furosemide (HDF, 40 mg furosemide bolus IV, followed by continuous IV infusion of 20 mg/h for a total of 8 hours), 2. low-dose furosemide (LDF, 40 mg furosemide bolus IV, followed by continuous IV infusion of 5 mg/h furosemide for a total of 8 hours), and 3. low-dose furosemide combined with low-dose dopamine (LDFD, 40 mg furosemide bolus IV, followed by continuous IV infusion of 5 mg/h furosemide plus 5μg/kg/min dopamine for a total of 8 hours) on diuresis, perceived dyspnea, renal function, electrolyte balance, total length of stay, and 60-day post-discharge outcomes in patients hospitalized with ADHF.

Conditions

• Acute Decompensated Heart Failure

Interventions

Type	Name	Description
DRUG	High-dose furosemide	High-dose furosemide (HDF): 20 mg/h continuous IV administration for 8 hours
DRUG	Low-dose furosemide	Low-dose furosemide (LDF): continuous IV administration of 5 mg/h furosemide
DRUG	Low-dose furosemide combined with low-dose dopamine	Low-dose furosemide combined with low-dose dopamine (LDFD): continuous IV administration of 5 mg/h furosemide combined with 5 μg/kg/min dopamine for a total of 8 hours

Timeline

• Start date: 2009-07-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2010-02-02
• Last updated: 2013-09-11

Locations

6 sites across 2 countries: United States, Greece