| Not Yet Recruiting | TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in C NCT07479849 | University Hospital, Angers | N/A |
| Recruiting | Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis NCT07496723 | Sanliurfa Education and Research Hospital | — |
| Recruiting | Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children NCT07008092 | KBC Split | — |
| Active Not Recruiting | Clinical Diagnosis of Acute Appendicitis with Normal WBCS Count with Role of Inflammatory Markers and Radiolog NCT06834958 | Assiut University | — |
| Recruiting | Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial NCT06699433 | Southern Medical University, China | N/A |
| Recruiting | Retrospective Acute Care Appendectomy Study NCT06624215 | Intuitive Surgical | — |
| Active Not Recruiting | Antibiotics vs Surgery in Acute Appendicitis NCT07492329 | Sebahattin Celik MD | N/A |
| Unknown | Are Double-ring Wound-edge Protectors Effective for Preventing Superficial Surgical Site Infection After Open NCT04860570 | Hospital Medina del Campo | — |
| Recruiting | Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy NCT06563349 | Medical University of Warsaw | Phase 4 |
| Completed | Efficacy of Transversus Abdominis Plane Block in Alleviating Acute Appendicitis NCT06808737 | Ankara City Hospital Bilkent | N/A |
| Completed | Management of Acute Appendicitis Pain in the Emergency Department NCT06808087 | Ankara City Hospital Bilkent | — |
| Completed | Prioritisation of Acute Appendicitis Using Appendistat Score NCT07197489 | University College, London | — |
| Unknown | Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis NCT06051825 | University Hospital of Split | — |
| Unknown | Clinical Trial for a Outpatient Clinical Management for Complicated Acute Appendicitis NCT06059365 | HJ23 | N/A |
| Withdrawn | Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations NCT05724628 | University of Texas Southwestern Medical Center | Phase 1 |
| Unknown | IA Model for Acute Appendicitis in CT NCT06175169 | Hallym University Medical Center | N/A |
| Unknown | Non Contrast CT in Acute Appendicitis NCT05815446 | Assiut University | — |
| Completed | "Stump-First" Approach in Laparoscopic Appendectomy NCT06897709 | Izmir City Hospital | N/A |
| Completed | Antibiotic Instillation in Appendicitis NCT05470517 | Johns Hopkins All Children's Hospital | Phase 2 |
| Unknown | Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis NCT05843630 | Kecheng Zhang | — |
| Completed | RICA (ERAS) Pathway Adherence and Early Discharge Feasibility After Urgent Uncomplicated Appendectomy (APENERA NCT07401407 | Hospital Galdakao-Usansolo | — |
| Completed | Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions NCT05651360 | Oslo University Hospital | — |
| Completed | Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation NCT06956638 | Nepalese Army Institute of Health Sciences | — |
| Completed | Lidocaine VS Hemodynamic, Metabolic and Hormonal Response NCT05238506 | Medical University of Warsaw | Phase 4 |
| Completed | Retrospective Comparison Between AirSeal® and Standard Insufflation in Appendicular Peritonitis NCT06734494 | Destinval Christelle | — |
| Completed | Appendicitis Choice of Treatment Study NCT04968782 | University of Washington | — |
| Completed | Plasma Sodium: a Predictor of Perforation in Acute Appendicitis. (The NAP-study) NCT04806789 | Urban Fläring | — |
| Completed | Validation and Comparison of the Appendicitis Inflammatory Response Score and Adult Appendicitis Score NCT04730752 | Nigde Omer Halisdemir University | — |
| Completed | Review of the Pathological Results of Appendectomy Specimens NCT05391269 | King Abdulaziz University | — |
| Unknown | Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous NCT04947748 | North Estonia Medical Centre | N/A |
| Completed | The Use of the Hem-o-lok Clip in Appendectomy: Single or Double? NCT04387370 | Ulas Aday | — |
| Completed | Variation in Acute Appendicitis During COVID-19 Pandemic in Italy NCT04649996 | University of Milano Bicocca | — |
| Recruiting | Web-based International Register of Emergency Surgery and Trauma NCT03643718 | A.O. Ospedale Papa Giovanni XXIII | — |
| Completed | Endoscopic Retrograde Appendicitis Therapy NCT04281251 | Chinese University of Hong Kong | N/A |
| Completed | Fetal Outcomes Among Pregnant Emergency General Surgery Patients NCT05085353 | Methodist Health System | — |
| Completed | The Role of Preoperative HALP Score in Differentiating Complicated Acute Appendicitis NCT07002671 | Kahramanmaras Sutcu Imam University | — |
| Completed | MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC NCT04615728 | Cambridge University Hospitals NHS Foundation Trust | — |
| Terminated | Modification and Validation of the RIPASA Score for Diagnosis of Acute Appendicitis NCT04207645 | Soba University Hospital | — |
| Completed | Alvarado Score in the Meta Department NCT07370896 | Hospital Departamental de Villavicencio | — |
| Completed | Presentation and Outcomes of Acute Appendicitis During COVID Pandemic NCT05104346 | Mansoura University | N/A |
| Completed | Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy NCT03886896 | Medical University of Warsaw | Phase 4 |
| Completed | The Role of Contrast Enhanced Ultrasound in Appendicitis NCT03687502 | Children's Mercy Hospital Kansas City | Phase 2 |
| Completed | The Utility of Immature Granulocyte Count on the Prediction of Acute Appendicitis in the Suspected Acute Appen NCT05033249 | Kahramanmaras Sutcu Imam University | — |
| Unknown | Optimizing the Diagnosis of Acute Appendicitis NCT04117061 | Vilnius University | N/A |
| Completed | Non-operative Treatment of Acute Non-perforated Appendicitis NCT04030741 | King Edward Medical University | Phase 2 / Phase 3 |
| Completed | Preoperative Immature Granulocyte Count and Percentage for Acute Appendisitis NCT04440150 | Kahramanmaras Sutcu Imam University | N/A |
| Completed | Technical Modifications of Appendicular Stump Closure During Laparoscopic Appendectomy NCT03750032 | University Hospital Ostrava | N/A |
| Completed | Free Text Prediction Algorithm for Appendicitis NCT03414853 | National University Hospital, Singapore | — |
| Enrolling By Invitation | Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis NCT03234296 | Turku University Hospital | N/A |
| Completed | Modified Enhanced Recovery Program in Emergency Surgery (MERES) NCT03754777 | Pirogov Russian National Research Medical University | N/A |
| Unknown | Single-incision Laparoscopic Surgery in Acute Abdomen NCT03198065 | National Taiwan University Hospital | N/A |
| Completed | Appendectomy Versus Conservative Treatment for Uncomplicated Acute Appendicitis NCT03080103 | Mauro Podda | — |
| Unknown | Acute Appendicitis and Microbiota - Etiology of Appendicitis and Antibiotic Therapy Effects NCT03257423 | Turku University Hospital | N/A |
| Active Not Recruiting | Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis NCT03236961 | Turku University Hospital | N/A |
| Completed | Medical Treatment for Acute Appendicitis NCT04594486 | Uşak University | — |
| Completed | Transversus Abdominis Plane Block in Acute Appendicitis Pain Managment NCT05004532 | Erol Olcok Corum Training and Research Hospital | — |
| Unknown | Comparing Proposed Algorithm and Current Practice in the Evaluation of Suspected Appendicitis NCT03324165 | Singapore General Hospital | N/A |
| Completed | Peritoneal Closure Versus Non Closure During Open Appendectomy NCT02803463 | Bezmialem Vakif University | N/A |
| Unknown | Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appen NCT02789865 | First Affiliated Hospital Xi'an Jiaotong University | Phase 2 |
| Unknown | The Onset Time of Rocuronium in Emergency and Elective Surgery NCT02634255 | Diskapi Yildirim Beyazit Education and Research Hospital | Phase 3 |
| Completed | Sensitivity and Specificity of the Alvarado Score for the Timely Differential Diagnosis of Acute Appendicitis NCT05168410 | Dr Annette Kaspar | — |
| Unknown | Diagnostic Accuracy of Emergency Physician Performed Bedside Ultrasound in Suspected Acute Appendicitis NCT02467959 | Antalya Training and Research Hospital | — |
| Completed | Laparoscopic Assisted or Total Laparoscopic Appendectomy NCT02673528 | Medical Park Gaziantep Hospital | — |
| Completed | Diffusion MRI in Appendicitis NCT04518436 | Yuksek Ihtisas University | — |
| Withdrawn | TAP Block for Laparoscopic Appendicectomy in Adults NCT03252561 | Oxford University Hospitals NHS Trust | N/A |
| Completed | Point of Care Ultrasound for Evaluation of Suspected Appendicitis in the Emergency Department NCT02731924 | WellSpan Health | — |
| Completed | Inflammatory Parameters as Predictive Factors for Complicated Appendicitis NCT05116124 | Centro Hospitalar do Tâmega e Sousa | — |
| Withdrawn | Identifiable Factors That May Lead to Postoperative Nausea and Vomiting After Simple Laparoscopic Appendectomy NCT02044640 | Brian Kenney | — |
| Completed | Feasibility of Outpatient Appendectomy for Acute Appendicitis NCT01839435 | Centre Hospitalier Universitaire, Amiens | Phase 3 |
| Unknown | Laparoscopic Appendectomy by Multi-port vs Single Port. NCT01720082 | Associazione Chirurghi Ospedalieri Italiani | Phase 3 |
| Completed | Acute Appendicitis: The Influence of C-reactive Protein and Leucocytes on Clinical Decision-making NCT02304653 | Odense University Hospital | — |
| Completed | The Performance of the APPY1 Test in the Evaluation of Possible Acute Appendicitis NCT01652170 | Venaxis, Inc. | — |
| Completed | Water And Saline Head-to-head In The Blinded Evaluation Study Trial NCT02714023 | University of Missouri-Columbia | N/A |
| Completed | Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis NCT01697059 | Rhode Island Hospital | N/A |
| Completed | Complement Diagnosis of Acute Appendicitis NCT03450642 | University of Exeter | — |
| Completed | Cost-effectiveness Analysis and Case-based Payment Norm Modeling on Appendicitis Patients at Hanoi Medical Uni NCT03504878 | Hanoi Medical University | — |
| Completed | A Trial on Laparoscopic Appendectomy Versus Single Port Appendectomy NCT01348464 | Gachon University Gil Medical Center | — |
| Completed | The Comparison of Single Incision Laparoscopic Appendectomy and Three Port Laparoscopic Appendectomy NCT01816568 | Maltepe University | N/A |
| Completed | Changes in the Treatment of Acute Appendicitis NCT06558760 | Medizinische Hochschule Brandenburg Theodor Fontane | — |
| Completed | Non Operative Treatment for Acute Appendicitis NCT01096927 | Maggiore Bellaria Hospital, Bologna | Phase 4 |
| Unknown | Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis NCT01022567 | Turku University Hospital | N/A |
| Completed | Transumbilical Single Incision Versus Conventional Three Incisions Laparoscopic Appendicectomy NCT01024439 | Pamela Youde Nethersole Eastern Hospital | N/A |
| Completed | Impact of CT on Diagnosis of Acute Appendicitis NCT01376466 | University of Aarhus | — |
| Completed | Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical NCT01524081 | The Faculty Hospital Na Bulovce | Phase 3 |
| Completed | Laparoscopic Versus Open Appendectomy NCT01967745 | Varazdin General Hospital | — |
| Completed | Patient Time and In-hospital Delay of Surgery Association With Complicated Appendicitis NCT04689906 | Rambam Health Care Campus | — |
| Completed | Preserving or Resecting the Normal Appendix in Patients Undergoing Laparoscopy Surgery for Suspected Appendici NCT06917612 | Herlev Hospital | — |
| Completed | Laparoscopic Versus Open Appendectomy NCT02867072 | University of Catania | Phase 4 |
| Completed | Single Incision Versus Conventional Laparoscopic Appendectomy NCT01424631 | Mansoura University | N/A |
| Completed | Perioperative Hyperoxygenation and Wound Site Infection Following Surgery for Acute Appendicitis NCT01002365 | Western Galilee Hospital-Nahariya | N/A |