NCT06051825

Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis

Diagnostic Importance of the Circulating C-reactive Protein in Blood and Saliva in Acute Appendicitis in Pediatric Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University Hospital of Split · Academic / Other
• Sex: All
• Age: 5 Years – 17 Years
• Healthy volunteers: —

Summary

Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.

Conditions

• Acute Appendicitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels	Blood analysis of CRP and WBC levels Saliva analysis of CRP levels

Timeline

• Start date: 2023-11-01
• Primary completion: 2024-10-30
• Completion: 2024-11-30
• First posted: 2023-09-25
• Last updated: 2023-09-25