NCT01022567

Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis

Study of Surgical Treatment (Open Appendicectomy) Versus Antibiotic Treatment (Ertapenem) in the Treatment of Acute Uncomplicated Appendicitis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 530 (actual)
• Sponsor: Turku University Hospital · Other Government
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation. At the same time other similar intra-abdominal infections, such as diverticulitis, are treated with antibiotics. There have been some encouraging reports on successful treatment of appendicitis with antibiotics and it has been estimated that operative treatment might be necessary for only 15 - 20 % of patients with acute appendicitis. The aim of this randomized prospective study is to compare operative treatment (open appendicectomy) with conservative treatment with antibiotics (ertapenem, Invanz). Before randomization acute uncomplicated appendicitis is diagnosed with a CT scan.The hypothesis of the study is that the majority of patients with uncomplicated acute appendicitis can be treated successfully with antibiotics and unnecessary appendicectomies can be avoided.

Conditions

• Acute Appendicitis

Interventions

Type	Name	Description
PROCEDURE	Appendicectomy	Standard appendicectomy
DRUG	Ertapenem	ertapenem 1g x 1 i.v.for three days + after discharge levofloxacin 500 mg 1 x 1 + metronidazole 500 mg 1x3 for 7 days p.o.

Timeline

• Start date: 2009-11-01
• Primary completion: 2012-06-01
• Completion: 2025-12-01
• First posted: 2009-12-01
• Last updated: 2018-06-28
• Results posted: 2017-02-23

Locations

6 sites across 1 country: Finland