| Not Yet Recruiting | Disposable Endoscope Platform in Third Space Endoscopic Procedures NCT06738628 | Baylor College of Medicine | — |
| Recruiting | PRospective Registry of Esophageal Motility NCT07506746 | IRCCS San Raffaele | — |
| Recruiting | Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM) NCT07496840 | Baylor College of Medicine | — |
| Recruiting | Safety and Efficacy of a Novel SpydrBlade Flexible Bipolar in POEM NCT07406945 | Chinese University of Hong Kong | N/A |
| Recruiting | Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy NCT06189859 | Cairo University | Phase 3 |
| Recruiting | POEM-F for Achalasia International Study NCT06042127 | Chinese University of Hong Kong | N/A |
| Completed | redoPOEM : Failure of a First POEM NCT06044155 | University Hospital, Bordeaux | — |
| Withdrawn | Prospective Collection of Outcome Data Post POEM-TIF Procedure NCT04052581 | Johns Hopkins University | — |
| Recruiting | Autonomic Dysfunction and Hemodynamic Instability During Per-oral Endoscopic Myotomy NCT05772260 | Gangnam Severance Hospital | — |
| Recruiting | VZV in the Enteric Nervous System: Pathogenesis and Consequences NCT05550194 | Vanderbilt University Medical Center | Phase 4 |
| Recruiting | The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor NCT07181070 | Federico II University | — |
| Unknown | POEM + F for Achalasia - a Pilot Study NCT05214443 | Chinese University of Hong Kong | N/A |
| Unknown | The Effect of Physiotherapy on Post POEM Reflux NCT05326113 | Institute for Clinical and Experimental Medicine | N/A |
| Recruiting | Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Dis NCT05905016 | AdventHealth | — |
| Recruiting | Analysis of Prevalence and Risk Factors Associated With Gastroesophageal Reflux Disease and Esophagitis After NCT05080634 | Maria Sklodowska-Curie National Research Institute of Oncology | — |
| Completed | ConMed Beamer Study NCT04752670 | Baylor College of Medicine | — |
| Recruiting | Comprehensive Esophageal Diagnostics Study NCT04641702 | Emory University | Phase 4 |
| Completed | Transoral Incisionless Fundoplication in Post-POEM GERD NCT04770441 | Baylor College of Medicine | — |
| Unknown | Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study NCT05041608 | Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University | — |
| Completed | Short Vs Standard Length Myotomy in Achalasia NCT04798547 | Northwestern University | N/A |
| Unknown | Post Operative Pain Control of POEM Procedure NCT04177342 | Chen Wannan | Phase 4 |
| Enrolling By Invitation | ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia NCT04065516 | Coordinación de Investigación en Salud, Mexico | N/A |
| Completed | Ropivacaine For Post-POEM Pain Control NCT03702647 | Lawrence Charles Hookey | N/A |
| Enrolling By Invitation | Botox or Botox With Esophageal Dilation in Patients With Achalasia NCT03654066 | Vanderbilt University Medical Center | Phase 4 |
| Active Not Recruiting | Development of Endoscopic Treatment for Achalasia NCT04180241 | Karolinska Institutet | N/A |
| Unknown | Peroral Endoscopic Myotomy for the Treatment of Achalasia NCT04640753 | Methodist Health System | — |
| Completed | Nasogastric Tube After Laparoscopic Heller-Dor Myotomy NCT05729971 | Federico II University | — |
| Terminated | Institutional Outcome Data From Per-oral Plication of the Esophagus NCT03875365 | Mayo Clinic | — |
| Withdrawn | Sensorimotor Dysfunction in Achalasia NCT02434991 | Mayo Clinic | N/A |
| Terminated | Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study NCT03411252 | Thomas Jefferson University | EARLY_Phase 1 |
| Completed | Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalas NCT03228758 | NYU Langone Health | N/A |
| Completed | Risk of Microbial Translocation in Patients Undergoing Per-Oral Endoscopic Myotomy (POEM) for Achalasia: Antib NCT03587337 | Istituto Clinico Humanitas | — |
| Terminated | Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia NCT02931565 | Cyclerion Therapeutics | Phase 2 |
| Enrolling By Invitation | Mechanisms of Weight Loss in Patients Diagnosed With Achalasia NCT03063463 | Vanderbilt University Medical Center | — |
| Unknown | Systematic IPP VS Symptomatic IPP in GERD Prevention After POEM for Achalasia. . A Comparative Retrospective A NCT04740437 | University Hospital, Montpellier | — |
| Unknown | Clinical Outcomes of Peroral Endoscopic Myotomy NCT02989883 | Asan Medical Center | N/A |
| Enrolling By Invitation | Outcome Analysis of POEM and Endoluminal Therapies NCT03123835 | University of California, Davis | N/A |
| Unknown | Laparoscopy Heller Myotomy With Fundoplication Associated Versus Peroral Endoscopic Myotomy (POEM) NCT02138643 | University of Sao Paulo General Hospital | N/A |
| Terminated | Achalasia Patient Reported Outcomes NCT02606578 | Mayo Clinic | — |
| Completed | POEM Anterior Versus Posterior Approach NCT02454335 | Johns Hopkins University | N/A |
| Enrolling By Invitation | Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository NCT02770859 | Indiana University | — |
| Unknown | POEM: Long vs Short Myotomy for Achalasia. RCT NCT03450928 | Catholic University of the Sacred Heart | N/A |
| Withdrawn | Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal NCT02428959 | Johns Hopkins University | N/A |
| Terminated | Per-Oral Endoscopic Myotomy for Esophageal Swallowing Disorders NCT02482337 | Baylor Research Institute | N/A |
| Completed | Peroral Endoscopic Myotomy (POEM) for Esophageal Motility NCT02314741 | University of Pennsylvania | N/A |
| Terminated | Achalasia: Mechanisms Underlying Treatment Failure NCT02055469 | Barts & The London NHS Trust | — |
| Unknown | Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Registry NCT02162589 | Weill Medical College of Cornell University | — |
| Completed | POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM) NCT01793922 | KU Leuven | N/A |
| Completed | Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia NCT01832779 | University of Florida | — |
| Withdrawn | Assessing the Efficacy of Steroid Treatment of Achalasia NCT01903486 | Mayo Clinic | Phase 4 |
| Completed | POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders NCT01512719 | Hadassah Medical Organization | N/A |
| Completed | Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia NCT01601678 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Prospective Study on the Feasibility and Results of POEM in Idiopathic Achalasia NCT02259283 | Istituto Clinico Humanitas | Phase 2 |
| Completed | A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia NCT01692106 | McMaster University | N/A |
| Completed | Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia NCT02073578 | Ohio State University | N/A |
| Completed | Evaluation of a Novel Endoscopic Treatment for Achalasia NCT01770249 | University Hospitals Cleveland Medical Center | N/A |
| Unknown | Personalized Peroral Endoscopic Myotomy for Achalasia NCT01570621 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 4 |
| Completed | Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure NCT01873300 | Massachusetts General Hospital | Phase 1 / Phase 2 |
| Completed | The Role That Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia NCT01584635 | Mayo Clinic | N/A |
| Completed | Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With NCT01438398 | Winthrop University Hospital | N/A |
| Terminated | Endoscopic Peroral Myotomy for Treatment of Achalasia NCT01405417 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Endoscopic Peroral Myotomy for Treatment of Achalasia NCT01405469 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Unknown | Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia NCT01302288 | The Oregon Clinic | Phase 2 |
| Completed | Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia NCT01399476 | The Oregon Clinic | N/A |
| Unknown | Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders NCT01524471 | Chinese University of Hong Kong | Phase 2 |
| Completed | Per-Oral Endoscopic Esophagomyotomy (POEM) NCT01635374 | Northwestern University | N/A |
| Completed | Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Esophageal Motility Disorders NCT01525732 | Chinese University of Hong Kong | N/A |
| Unknown | Hot Water Drinking Therapy in Achalasia NCT01863966 | Peking Union Medical College Hospital | N/A |
| Withdrawn | Correlation of High Resolution Esophageal Manometry With Symptoms NCT01202929 | University of Louisville | — |
| Completed | Per-Oral Endoscopic Myotomy NCT01402518 | University of California, San Diego | — |
| Unknown | Efficacy of Dark Chocolate in Achalasia Patients NCT00790465 | Tel-Aviv Sourasky Medical Center | Phase 1 / Phase 2 |
| Completed | Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients NCT00856921 | Asan Medical Center | — |
| Terminated | vMII for Measurement of Oesophageal Bolus Transport and Reflux NCT00604942 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Active Not Recruiting | Minimally Invasive Surgery of the Gastro-esophageal Junction NCT01799967 | Ottawa Hospital Research Institute | — |
| Completed | A Prospective Study Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia NCT01933373 | Karolinska University Hospital | N/A |
| Unknown | Outcome of Symptoms in Patients Undergoing a Heller Myotomy NCT00519220 | University of South Florida | — |
| Terminated | Comparison of Esophageal and Anorectal Manometry Catheters NCT00204763 | University of Utah | Phase 4 |
| Completed | Pneumatic Dilatation or Surgical Myotomy for Achalasia NCT02086669 | Karolinska University Hospital | Phase 2 |
| Unknown | Epidermoid Cancer Development in Esophageal Achalasia NCT03546998 | Sandro Mattioli | — |