NCT03546998

Epidermoid Cancer Development in Esophageal Achalasia

Incidence and Risk Factors for Development of Epidermoid Carcinoma in Esophageal Achalasia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 681 (estimated)
• Sponsor: Sandro Mattioli · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined. Incidence and risk factors for epidermoid carcinoma development in achalasia patients were investigated.

Detailed description

In order to define incidence and risk factors for epidermoid carcinoma 681 patients affected by esophageal achalasia observed since 1973 were followed up with no time limits according to a prospective follow-up protocol. The local institutional review board approved using the database from the division of thoracic surgery for research purposes. Clinical, radiological and endoscopic data of achalasia patients were collected and analyzed.

Conditions

• Achalasia
• Epidermoid Carcinoma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Clinical instrumental examinations	Achalasia patients were periodically submitted to clinical assessment, barium swallow (esophageal diameter and residual barium column were measured), endoscopy. Mucosal esophageal biopsies were taken in order to diagnose dysplasia or epidermoid carcinoma.

Timeline

• Start date: 1973-01-01
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2018-06-06
• Last updated: 2018-06-06

Locations

1 site across 1 country: Italy