Trials / Unknown
UnknownNCT00790465
Efficacy of Dark Chocolate in Achalasia Patients
Efficacy of Dark Chocolate in Achalasia Patients: Placebo-Controlled Study
- Status
- Unknown
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- Tel-Aviv Sourasky Medical Center · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Flavanols, present in dark chocolate, were shown to induce Nitric Oxide synthesis. Since Nitric Oxide facilitates smooth muscle relaxation, it might ease the relaxation of the LES (lower esophageal sphincter)as well. The objective of the present study is to evaluate tha efficacy of dark chocolate in improving LES relaxation in achalasia patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | dark chocolate | 21 g/d of dark chocolate for 2 weeks (7 g. before each meal). 7 grams of dark chocolate at day 1 during manometry. |
| DIETARY_SUPPLEMENT | placebo chocolate with crossover to dark chocolate | Placebo at day 1 during manometry, and than crossover to dark chocolate for 2 weeks treatment. |
Timeline
- Start date
- 2008-11-01
- Primary completion
- 2009-11-01
- Completion
- 2010-11-01
- First posted
- 2008-11-13
- Last updated
- 2008-11-13
Source: ClinicalTrials.gov record NCT00790465. Inclusion in this directory is not an endorsement.