NCT03141619

Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Dr. Gordon Boyd · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is designed to test the hypothesis that poor cerebral perfusion during critical illness is a risk factor for acute and long-term neurological dysfunction among survivors. We use near-infrared spectroscopy to measure brain tissue oxygenation as a non-invasive surrogate marker for cerebral perfusion. Acute neurological dysfunction is defined as the presence of delirium, which is assessed using the Confusion Assessment Method-Intensive Care Unit (CAM-ICU). Chronic neurological dysfunction is defined as having quantitative impairments on robotic testing (KINARM robot) and traditional neuropsychological screening (Repeatable Battery for the Assessment of Neuropsychological Status).

Conditions

• Critical Illness
• Respiratory Failure
• Shock
• Delirium

Timeline

• Start date: 2017-10-13
• Primary completion: 2024-06-01
• Completion: 2025-06-01
• First posted: 2017-05-05
• Last updated: 2023-12-26

Locations

1 site across 1 country: Canada