Wrinkle

127 registered clinical trials studyying Wrinkle — 13 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines NCT07421544	Goldman, Butterwick, Fitzpatrick and Groff	Phase 4
Recruiting	Pre-marketing Trial to Assess Safety and Efficacy of 'Volumizing Filler Based on Hyaluronic Acid and Recombina NCT06336044	Taumedika s.r.l.	N/A
Not Yet Recruiting	Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Ag NCT07221461	Goldman, Butterwick, Fitzpatrick and Groff	Phase 2
Recruiting	A Prospective Controlled Study to Evaluate the Safety and Effectiveness of Thermage® FLX Radiofrequency Treatm NCT07187297	Bausch Health Americas, Inc.	N/A
Completed	Efficacy of Four Topical Products to Improve Skin Longevity NCT07118943	Amazentis SA	N/A
Completed	Anti-aging Efficacy of Food Supplement and Cosmetic Routine NCT06932770	Amazentis SA	N/A
Completed	Main Study: A Study to Evaluate the Effectiveness and Safety of GAL1906 for Correction of Wrinkles in the déco NCT04717934	Galderma R&D	N/A
Enrolling By Invitation	Clinical Study to Evaluate the Efficacy and Safety of Matrix Pro Treatment NCT06726122	Candela Corporation	N/A
Not Yet Recruiting	Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides NCT06448676	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	Phase 4
Recruiting	AVAVA MIRIA General Use NCT06868615	AVAVA, Inc.	N/A
Recruiting	The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles NCT06571721	Integrative Skin Science and Research	N/A
Not Yet Recruiting	Efficacy and Safety of 675-nm Laser for Dorsal Hand Rejuvenation NCT06486727	Mahidol University	N/A
Completed	Device for Improving Skin Quality and Texture on the Face and Neck NCT06645366	BTL Industries Ltd.	N/A
Recruiting	Assessing the Impact of Botulinum Toxin Type A on Facial Wrinkles: A Comprehensive Clinical Investigation NCT06385171	Global Aesthetics LLC	—
Completed	Healing Study of Fractional Skin Resurfacing and Tissue Histopathology After Ellacor Treatment NCT06502470	Cytrellis Biosystems, Inc.	N/A
Completed	A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction NCT06351293	Galderma R&D	N/A
Completed	Confirmatory Study: Assessing the Efficacy and Safety of the AcusMu Microneedle Patch in Treating Periorbital NCT06158867	AcusMu Medtech Co., Ltd.	—
Completed	A 56-day Clinical Study on Facial Skin Rejuvenation NCT06188338	Botanee Group Co., Ltd.	N/A
Completed	Safety and Efficacy of the BTL-754 Device for Laser Skin Resurfacing Treatment of the Face NCT06158438	BTL Industries Ltd.	N/A
Active Not Recruiting	AV-23-001 AVAVA MIRIA Pilot Study NCT06557434	AVAVA, Inc.	N/A
Completed	A Retrospective Review Evaluating the Matrix Pro Applicator for Treatment of Wrinkles NCT06219278	Candela Corporation	—
Recruiting	The Effects of Almond on Facial Skin Collagen and Wrinkles NCT06074276	Integrative Skin Science and Research	N/A
Active Not Recruiting	Clinical Study to Evaluate the Safety and Efficacy of Candela Technology NCT06202274	Candela Corporation	N/A
Completed	Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional NCT06366503	Revision Skincare	N/A
Completed	A 28-day Clinical Study on Facial Skin Rejuvenation NCT06140628	Botanee Group Co., Ltd.	N/A
Completed	A Clinical Study to Assess the Safety and Effectiveness of Anti-Ageing and Skin Brightening Gel NCT06123572	NovoBliss Research Pvt Ltd	N/A
Recruiting	Feasibility Study to Collect and Assess Safety Data for a Radiofrequency Microneedling Device for Electrocoagu NCT05987319	Cynosure, Inc.	N/A
Terminated	Topical Palm Tocotrienols on Skin Biophysical Properties NCT05787743	Universiti Sains Malaysia	N/A
Completed	Safety and Efficacy of SofWave Treatment to Lift the Upper Lip and Improve the Peri-Oral Rhytids NCT06104514	Sofwave Medical LTD	N/A
Completed	Clinical Study for the Efficacy Evaluation of a Food Supplement NCT06453837	Mibelle Group Biochemistry	N/A
Recruiting	Evaluation of Performance and Safety of INNEA and INNEA AQUA for the Treatment of Cheek and décolletage Wrinkl NCT07331181	Innate srl	N/A
Completed	Prospective Study of Topical Adapinoid Versus Topical Retinol NCT05778760	Integrative Skin Science and Research	N/A
Unknown	Prospective Study of Topical Vitamin C (THDA) Versus Topical Vitamin C (THDA) With Acetyl Zingerone NCT05779280	Integrative Skin Science and Research	N/A
Completed	Anti-Wrinkle Efficacy Study of an Eye-Cream NCT05805735	Amazentis SA	N/A
Unknown	Skin Rejuvenation With Topical Extract and Other Nutraceuticals NCT05734703	Medical Life Care Planners, LLC	EARLY_Phase 1
Completed	Open Label Study Exploring Tissue Histopathology After Ellacor® Procedure in an Abdominoplasty Model. NCT06421207	Cytrellis Biosystems, Inc.	N/A
Unknown	Safety and Efficacy Evaluation of the Mosaic Ultra Device NCT06117293	CynosureLutronic	N/A
Unknown	Evaluation of Efficacy and Safety of the triLift™ System NCT05773924	Lumenis Be Ltd.	N/A
Completed	Threads Insertion in Forehead Static Wrinkles NCT06179082	Zagazig University	N/A
Unknown	The Effects of a 3-Part Skin Care Regimen on Facial Wrinkles and Biophysical Attributes NCT05698485	Integrative Skin Science and Research	N/A
Unknown	The Effects of a 5-Step Skin Regimen on Pigmentation and Appearance Related Biophysical Properties NCT05688527	Integrative Skin Science and Research	N/A
Completed	Safety and Efficacy Study of Vasu Facial Beauty Oil NCT05646953	NovoBliss Research Pvt Ltd	N/A
Completed	Straberi Epistamp Needling Treatment For Skin Rejuvenation NCT04742803	Universal Skincare Institute	N/A
Completed	Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles NCT05742399	Alexandria University	Phase 1 / Phase 2
Completed	BTL-785F Device for Non-invasive Reduction of Wrinkles and Overall Facial Improvement NCT05524779	BTL Industries Ltd.	N/A
Completed	Clinical Investigation to Assess Safety and Performance of Dermal Filler of Hyaluronic Acid NCT05450380	Mesoestetic Pharma Group S.L.	N/A
Completed	Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Radiofre NCT06157853	Revision Skincare	N/A
Completed	BTL-785F Device for Non-invasive Facial Rejuvenation in Patients Injected With Botulinum Toxin NCT05524766	BTL Industries Ltd.	N/A
Completed	Study to Identify if Chemist Confessions Retinol Cream Works to Improve the Appearance of Early Signs of Aging NCT05039476	Chemist Confessions, Inc.	N/A
Completed	BTL-785F Device for Non-invasive Treatment of Wrinkles and Improvement of the Face Appearance NCT05524805	BTL Industries Ltd.	N/A
Completed	BTL-785F Device for Improving the Structure of Facial Muscles NCT05524740	BTL Industries Ltd.	N/A
Completed	Clinical Study To Evaluate Paired Treatment With An Alexandrite Laser And Radiofrequency Microneedling For Fac NCT05388604	Cynosure, Inc.	N/A
Completed	Clinical and Histological Evaluation of BTL-785F Device for Non-invasive Treatment of Face NCT05524662	BTL Industries Ltd.	N/A
Completed	BCT-HA Kit for Dehydrated and Wrinkled Skin NCT05514834	University of Minnesota	EARLY_Phase 1
Active Not Recruiting	Clinical Feasibility Study to Evaluate the Safety and Performance of the Profound Matrix System NCT06157567	Candela Corporation	N/A
Completed	To Show the Safety and Effectiveness of the Demetech Barbed Polydioxanone (PDO) Suture NCT06404372	Sutura Medical Technology LLC	N/A
Completed	An Exploratory Investigation of a Novel Skincare Regimen NCT05517720	Trophy Skin	N/A
Completed	Safety and Efficacy of the BTL-785F Device for Non-invasive Reduction of Wrinkles NCT05476211	BTL Industries Ltd.	N/A
Unknown	Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles NCT05091788	Venus Concept	N/A
Completed	Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Fi NCT05215054	GCS Co., Ltd	N/A
Completed	Study to Identify if Saie Beauty's Under Eye Concealer Works to Improve Under-Eye Skin Appearance and Reduce I NCT05231681	Saie Beauty	N/A
Unknown	Placebo Controlled Efficacy Evaluation of the Hydrolyzed Collagen Peptide In Adult Females NCT05235997	Sel Sanayi Urunleri Ticaret ve Pazarlama A.S.	N/A
Unknown	Evaluating the Safety and Effectiveness of the Tixel Fractional System in the Treatment of Photodamage at Low NCT05182502	Eric Bernstein, MD	N/A
Completed	A 12 Week Study to Evaluate the Efficacy of an Eye Cream NCT05807620	Revision Skincare	N/A
Completed	Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Hybrid-F NCT06436261	Revision Skincare	N/A
Completed	Evaluation of Safety and Efficacy of the BTL-785F Device for Non-invasive Facial Remodeling NCT05525026	BTL Industries Ltd.	N/A
Completed	Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles NCT05162300	Vitality Institute Medical Products	Phase 4
Completed	BTL-785F Device for Non-invasive Reduction of Wrinkles NCT05519124	BTL Industries Ltd.	N/A
Completed	Post Market Usability Evaluation Of The PicoSure Pro Device NCT05102617	Cynosure, Inc.	N/A
Completed	A Clinical Study to Evaluate the Long-Term Efficacy and Tolerability of a Daily Anti-Aging Daily Serum NCT05514782	Revision Skincare	N/A
Completed	Comparing Polydioxanone Thread Embedding Acupuncture and Manual Acupuncture for Nasolabial Fold Reduction NCT05098912	Indonesia University	N/A
Completed	Post Market Study To Collect Efficacy Data For The Treatment Of Wrinkles With A Radiofrequency Device NCT05096247	Cynosure, Inc.	N/A
Unknown	Soluble Hyaluronic Acid Microneedle VS. Non-ablative Fractional Laser on Infraorbital Wrinkles. NCT04989361	Shanghai Dermatology Hospital	N/A
Unknown	A Prospective, Single Center, Single-Arm Clinical Study of 20 Participants to Reduce the Appearance of the Per NCT05282979	Physicians Laser and Dermatology Institute	N/A
Completed	Split-face Study: Cosmetic Botulinum Toxin Type A Injection Under Electromyography-guidance Versus Conventiona NCT05517538	Mohamed Hayder Oleish Salih	N/A
Completed	Comparison of the Effects of Two Frequencies of Application of Photobiomodulation on Facial Rejuvenation NCT04911140	University of Nove de Julho	N/A
Terminated	Study To Assess The Safety And Efficacy Of The Tempsure Flexsure Applicators For Abdominal Wrinkles NCT04930705	Cynosure, Inc.	N/A
Completed	AVAVA SR-1 Wrinkles and BPL Study NCT04925921	AVAVA, Inc.	N/A
Completed	Post Market Clinical Follow Up Study to Collect Additional Data and Imaging NCT04881058	Cynosure, Inc.	N/A
Completed	A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment f NCT05423873	Revision Skincare	N/A
Completed	RHA® 4 NLF Cannula NCT04754646	Teoxane SA	N/A
Completed	Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Peri NCT04639713	Novoxel Ltd.	N/A
Completed	Clinical and Histological Evaluation of BTL-785F Non-invasive Treatment for Facial Rejuvenation NCT05987917	BTL Industries Ltd.	N/A
Completed	Anti-ageing Efficacy of a Cosmetic Formulation Containing NMN (2%) Versus Placebo NCT04685096	Seneque SA	—
Completed	RHA® Redensity Eye Versus No-treatment for the Infra-Orbital Hollows NCT04577898	Teoxane SA	N/A
Completed	Fractional Radiofrequency for Treatment of Acne Scars and Wrinkles NCT05827510	BTL Industries Ltd.	N/A
Completed	Clinical Evaluation to Assess the Safety and Efficacy of GentleMax Pro Plus NCT04993066	Candela Corporation	N/A
Completed	Functional Usability and Feasibility Testing of the Profound Matrix™ System NCT06192550	Candela Corporation	N/A
Completed	Study to Evaluate the Performance and Safety of the Medical Device Plenhyage® NCT04650620	I.R.A. Istituto Ricerche Applicate S.p.A.	N/A
Active Not Recruiting	A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen NCT04540900	Krystal Biotech, Inc.	Phase 1
Completed	A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum NCT05271136	Revision Skincare	N/A
Unknown	Clinical Evaluation to Demonstrate the Safety and Performance of the Candela PicoWay System™ NCT04727099	Candela Corporation	N/A
Completed	Study to Evaluate the Efficacy of the décoLITE LED Device in Treating the Signs of Skin Aging of the décolleta NCT06542341	Steven Baker	N/A
Completed	An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream NCT04911374	Revision Skincare	N/A
Completed	Evaluate The Performance And Safety Of The Medical Device Jalucomplex® NCT04103918	I.R.A. Istituto Ricerche Applicate S.p.A.	N/A
Active Not Recruiting	Restylane Refyne for Correction of Horizontal Neck Rhytides NCT04162496	Siperstein Dermatology	N/A
Completed	Open, Non-Comparative Study To Evaluate The Performance Of The Medical Device JANESSE® NCT04103125	I.R.A. Istituto Ricerche Applicate S.p.A.	N/A
Completed	Evaluation of Safety and Efficacy of the BTL-785F Device for Non-invasive Reduction of Wrinkles NCT04447963	BTL Industries Ltd.	N/A
Withdrawn	Impact of Near-Infrared Vein Mapping on Outcomes and Satisfaction After Botox/Filler Treatment NCT04240080	Mayo Clinic	N/A
Unknown	Association of Photobiomodulation With Platelet Rich Plasma Intradermal Injection for Facial Rejuvenation NCT04145999	University of Nove de Julho	Phase 2
Completed	Renuvion Dermal System for Dermal Resurfacing NCT04185909	Apyx Medical	N/A
Completed	Safety and Efficacy of SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Ey NCT04146584	Sofwave Medical LTD	Phase 2
Completed	Open Label Extension for 43USSA1812 NCT04595331	Galderma R&D	N/A
Completed	Injection Site Pain Botulinum Toxin Reconstituted in NS With and Without Sodium Bicarbonate NCT04579419	King Abdulaziz Medical City	Phase 3
Completed	Study To Assess A Radiofrequency Microneedling Device For Dermatologic Conditions NCT05097157	Cynosure, Inc.	N/A
Completed	Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles NCT04057768	Venus Concept	N/A
Completed	Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles NCT03776461	Venus Concept	N/A
Completed	Evaluation of the Benefits of FloraGLO™ Lutein on Skin Health NCT03769779	Kemin Foods LC	N/A
Unknown	Restylane Silk Microinjections to Cheeks NCT03742479	Goldman, Butterwick, Fitzpatrick and Groff	N/A
Unknown	Micro-injections of Transparent Hyaluronic Acid Gel (Restylane® Silk) for Rejuvenation of the Aging Cheek NCT03461198	Goldman, Butterwick, Fitzpatrick and Groff	N/A
Completed	Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles NCT03831477	Venus Concept	N/A
Unknown	Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate t NCT03793348	Cytrellis Biosystems, Inc.	N/A
Completed	The Effect of Almonds on Facial Aesthetics and Modulation of the Microbiome and Lipidome NCT03729700	University of California, Davis	N/A
Completed	The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation NCT04128046	New York Medical College	N/A
Completed	A Study on the Effectiveness and Safety Evaluation of Combination Therapy With 1,927nm Thulium Laser and Fract NCT03739398	Yonsei University	N/A
Completed	Influence of Mango Intake of Skin Health in Postmenopausal Women NCT03590756	University of California, Davis	N/A
Completed	Lutronic Genius System for Neck Treatment NCT03534609	CynosureLutronic	N/A
Terminated	A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared W NCT03454672	Novoxel Ltd.	N/A
Unknown	Safety and Efficacy of the BTL-FR2000 Device for the Treatment of Facial Wrinkles NCT03548025	BTL Industries Ltd.	N/A
Unknown	Secret Micro-Needle Fractional RF System® for the Treatment of Facial Wrinkles NCT03426098	Goldman, Butterwick, Fitzpatrick and Groff	N/A
Withdrawn	Restylane Silk for Treatment of Chest Wrinkles NCT03324997	Heidi Waldorf	Phase 2
Completed	Evaluation of Cutera Excel V™ Laser With Green Genesis and Micro-Lens Array (MLA)Attachment NCT03424304	Cutera Inc.	N/A
Completed	Comparison of the Cosmetic Effects of Bakuchiol and Retinol NCT03112863	University of California, Davis	EARLY_Phase 1
Completed	RHA Redensity - Perioral Rhytids NCT03092219	Teoxane SA	N/A
Completed	Evaluation of Safety and Efficacy of Micro-coring Device for Treatment of Facial Wrinkles and Skin Laxity NCT03228641	Cytrellis Biosystems, Inc.	N/A
Completed	Efficacy and Safety Study of SkinPlus-Hyal® to Nasolabial Fold NCT01940575	Seoul National University Hospital	N/A
Completed	Fractional CO2 Laser System (Fraxel Repair Laser) Intended for Treatment of Perioral Rhytides/Wrinkles NCT03715049	University of Texas Southwestern Medical Center	N/A