NCT05742399

Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles

Clinical Evaluation of the Efficacy and Safety of Novel Drug-free Hyaluronic Acid Topical Nano-carrier in Periocular Rejuvenation

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

In this study, The investigators aims to evaluate the efficacy and safety of topical hyaluronic acid nanoparticles as a novel nanodermatological tool in periocular rejuvenation as a replacement approach of invasive dermal filler injections.

Detailed description

Tear trough deformity is a main concern of many people (males or females) with age range of 21 to 65 years old or older. Such condition is characterized by a sunken appearance of the eye that results in an aged and dissipated appearance to the eye.Treatment modalities range from camouflage make up, laser resurfacing, platelet-rich plasma therapy, carboxy therapy, mesotherapy, volume augmentation with injectable hyaluronic acid fillers and fat, as well as surgical procedures such as blepharoplasty. Consequently, safe, effective and less invasive treatment options of the tear trough have remained a challenge. The study will include 30 adult patients (male or female) suffering tear trough deformity. They will be selected from Dermatology Outpatient Clinic of Alexandria Main University Hospital.

Conditions

• Tear Trough Eyelid Deformity
• Dark Eyelids
• Wrinkle

Interventions

Type	Name	Description
DRUG	Hyaluronic acid NanoGel	Hyaluronic acid nanoparticles (2%)
DRUG	Placebo gel	conventional gel having the same color, form and packaging

Timeline

• Start date: 2022-12-21
• Primary completion: 2023-09-15
• Completion: 2024-01-15
• First posted: 2023-02-24
• Last updated: 2025-01-31

Locations

1 site across 1 country: Egypt