NCT06351293

A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction

A Randomized, Split-face Clinical Study on Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Galderma R&D · Industry
• Sex: All
• Age: 22 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This is a randomized, split-face, subject-blinded, comparative study. Subjects will receive initial treatment with Defyne on one of the NLFs and with RHA3 on the other based on the pre-determined randomization. 4 weeks after the initial treatment, subjects will receive optional touch-up on one side or both sides at the Investigator's discretion for optimal correction. Subjects to return to the site at Month 3, 6, and 12 for follow-ups.

Conditions

• Wrinkle

Interventions

Type	Name	Description
DEVICE	Defyne Treatment in Nasolabial Fold	Defyne will be injected into left or right nasolabial fold, per randomization.
DEVICE	RHA3 Treatment in Nasolabial Fold	RHA3 will be injected into left or right nasolabial fold, per randomization.

Timeline

• Start date: 2024-02-21
• Primary completion: 2025-03-17
• Completion: 2025-04-30
• First posted: 2024-04-08
• Last updated: 2026-01-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study