| Recruiting | Postoperative Hypocalcemia After Thyroidectomy NCT07428057 | Minia University | — |
| Recruiting | Multimodal Assessment of Malignancy in Atypia of Undetermined Significance in Thyroid Nodules Using Ultrasound NCT07488325 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Recruiting | Active Surveillance for Bethesda IV Thyroid Nodules NCT07370675 | Christian Grønhøj Larsen | N/A |
| Recruiting | A Study of Multiparametric Ultrasound Imaging Methods NCT07270237 | Memorial Sloan Kettering Cancer Center | N/A |
| Enrolling By Invitation | Comparing a New 3D Technology Used to Measure Thyroid Nodule Volume to Standard Ultrasound NCT07178080 | Sarasota Memorial Health Care System | N/A |
| Recruiting | Prospective Evaluation of the Pulse Biosciences nPulse™ Vybrance™ Percutaneous Electrode System NCT07287176 | Pulse Biosciences, Inc. | N/A |
| Recruiting | TRAIL Study: Feasibility and Pilot NCT06220656 | Dartmouth-Hitchcock Medical Center | N/A |
| Not Yet Recruiting | Accuracy of FNAC in Diagnosis of Thyroid Nodules NCT06782828 | Assiut University | — |
| Recruiting | Surgical Competency for Robot-Assisted Thyroidectomy: Construction and Validation of a Robotic Thyroidectomy A NCT06730321 | Shanghai 6th People's Hospital | — |
| Recruiting | Ultrasound-guided Thermal Ablation for Bethesda III/IV Thyroid Nodules NCT06733753 | Chinese PLA General Hospital | — |
| Not Yet Recruiting | Active Surveillance Program in Thyroid Nodules NCT06653257 | Centro de Excelencia en Enfermedades de Cabeza y Cuello | — |
| Recruiting | Myo-inositol and Selenium in Indeterminate Thyroid Nodules (TIR3a) NCT06736015 | Regina Elena Cancer Institute | N/A |
| Recruiting | Efficacy and Safety of Prunella Oral Liquid in the Treatment of Thyroid Nodules NCT06423235 | Xintian Pharmaceutical | Phase 4 |
| Recruiting | Preoperative Hemogram Parameters and BRAF Molecular Test Detected by Bethesda 3 Cytology. NCT06539702 | Saglik Bilimleri Universitesi | — |
| Recruiting | Role of TIRADS and Bethesda Scoring Systems in Management of Thyroid Nodules NCT06417463 | Sohag University | — |
| Recruiting | Renovated Prediction Model for Difficult Transoral and Submental Endoscopic Thyroidectomy NCT06738888 | Shanghai 6th People's Hospital | — |
| Recruiting | Radiofrequency Ablation Study in LatinX Patients NCT05903196 | Northwell Health | N/A |
| Completed | Virtual Reality Glasses on Applied During Thyroid Fine Needle Aspiration Biopsy NCT06823687 | Istanbul Sabahattin Zaim University | N/A |
| Completed | Human-AI Collaboration for Ultrasound Diagnosis of Thyroid Nodules - a Clinical Trial NCT06306599 | Rigshospitalet, Denmark | N/A |
| Unknown | B-mode Ultrasound, Sono-Elastography, and Diffusion-weighted Imaging MRI in Thyroid Nodules NCT06029946 | Assiut University | — |
| Completed | Artificial Intelligence-assisted Contrast-enhanced Ultrasound Diagnosis of Thyroid Nodules NCT05982821 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | N/A |
| Unknown | Elastography and FNAC in Thyroid Nodule NCT05734326 | Assiut University | — |
| Recruiting | The Safety and Feasibility of Radiofrequency Ablation to Treat Low-risk Thyroid Cancer NCT06929650 | University Health Network, Toronto | N/A |
| Unknown | Multiparameter Ultrasound Based-AI for the Diagnosis of Thyroid Nodules NCT05816629 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Recruiting | CEUS Improves the Diagnostic Performance of SRSS of Thyroid Carcinoma NCT06146764 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Recruiting | Cognition and QoL After Thyroid Surgery NCT05088187 | Karolinska University Hospital | — |
| Not Yet Recruiting | Assessment the Cancer Risk of Indeterminate Thyroid Nodules Through Integration of Clinical, Ultrasonographic NCT05428371 | University of Cagliari | — |
| Unknown | Intervention in Single Thyroid Nodule. NCT05658809 | Assiut University | N/A |
| Completed | Da-vinci sp Versus xi Thyroid Surgery NCT06573268 | Inha University Hospital | — |
| Recruiting | Health-Related Quality of Life and Emotions in Patients with Thyroid Nodules NCT06610604 | Ming-an Yu | — |
| Completed | Comparison Between Combined Scoring of Bethesda Cytology and TIRADS Ultrasound With Histopathology in Thyroid NCT06391021 | Tribhuvan University, Nepal | — |
| Unknown | Clinical Study of Ultrasonic Artificial Intelligence and Fine Needle Aspiration in Qualitative Diagnosis of Th NCT05407506 | Luo Dingcun | N/A |
| Unknown | Molecular Profile of Thyroid Nodules NCT05323669 | Belarusian State Medical University | — |
| Completed | The Application Value of Deep Learning-Based Nomograms in Benign-Malignant Discrimination of TI-RADS Category NCT06258044 | Ma Zhe | — |
| Unknown | Verbal Synchrony, Satisfaction and Decision-making in Face-to-face Consultations NCT06342739 | European Institute of Oncology | — |
| Completed | The Ultracyt Study - is EU-TIRADS Useful in Selecting Nodules for Fine Needle Aspiration Cytology? NCT05583097 | Vastra Gotaland Region | N/A |
| Recruiting | Decision Aid and Thyroid Nodules Management NCT05264857 | Stony Brook University | N/A |
| Unknown | Mini-flap BABA (Bilateral Axillo-breast Approach) Robotic Thyroidectomy is Safe NCT05216718 | Inje University | N/A |
| Completed | The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer NCT05132478 | University of Wisconsin, Madison | N/A |
| Unknown | Spinal Needles in Ultrasound-guided Fine Needle Aspirations From Thyroid Nodules NCT04879355 | Preben Homøe | N/A |
| Unknown | NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules NCT05025046 | Rigen Biotech | — |
| Unknown | Effect of Anti-adhesion Barrier on the Voice Quality After Thyroidectomy. NCT04853680 | Inha University Hospital | N/A |
| Unknown | Scoring System for Thyroid Gland Pathologies NCT04904159 | Dr. Lutfi Kirdar Kartal Training and Research Hospital | — |
| Completed | Analgesia for Thyroidectomy Using Bilateral Superficial Cervical Plexus Block With Bupivacaine Only or Adding NCT05180214 | Sohag University | Phase 2 |
| Recruiting | Radiofrequency Ablation in TIR3A Nodules With Negative Genetic Evaluation NCT05765695 | Istituto Auxologico Italiano | N/A |
| Unknown | Surgical Versus Non Surgical Management of Thyroid Nodule NCT04580199 | Mahmoud Fahd | N/A |
| Completed | Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules NCT04277455 | Johnson Thomas | N/A |
| Unknown | In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules NCT04730726 | University Medical Center Groningen | N/A |
| Unknown | Protein Classifier for Thyroid Indeterminate Nodules NCT04477798 | Luo Dingcun | N/A |
| Unknown | FNA Guided Ultrasonography Needle Technique Axial Vs Lateral Approach Study NCT04458233 | Ziv Hospital | N/A |
| Unknown | Benign Thyroid Nodules / Benign Goiter. What Subjective Problems Are Improved With an Operation and Can This b NCT05526261 | Linkoeping University | — |
| Unknown | Malignancy Predictors, Bethesda and TI-RADS Scores Correlated With Final Histopathology in Thyroid Diseases NCT04411290 | Umraniye Education and Research Hospital | — |
| Unknown | Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort NCT04396912 | Umraniye Education and Research Hospital | — |
| Unknown | Comparison of Anesthesia Effects of Sevoflurane and Propofol Combined With Dexmedetomidine in Intraoperative N NCT04680650 | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | N/A |
| Unknown | Elastography in Thyroid Nodules NCT04312646 | Assiut University | — |
| Unknown | Energy Device Study in Transoral Endoscopic Thyroidectomy NCT04320901 | Inha University Hospital | N/A |
| Completed | 2-day Prophylactic Antibiotic is Effective in Transoral Endoscopic Thyroidectomy NCT04268407 | Chang Gung Memorial Hospital | N/A |
| Unknown | Thyroid Cancer and Photoacoustic Imaging NCT04248166 | Seoul St. Mary's Hospital | N/A |
| Completed | Comparison of TOETVA and Conventional Thyroidectomy NCT04647006 | MUnlu | N/A |
| Terminated | Utility of Contrast-Enhanced Sonography and Shear Wave Elastography NCT04614389 | University of Southern California | N/A |
| Unknown | Clinical Diagnostic Approach for Cases of Thyroid Nodules NCT03884140 | Assiut University | — |
| Unknown | Voice Outcomes Following Thyroidectomy NCT03657654 | University of Virginia | — |
| Unknown | Modified Cormack Lehane Scores Evaluated by Laryngoscopy During Awake Versus Under General Anesthesia NCT03826680 | Istanbul University | N/A |
| Completed | Effect of Dill in Thyroiditis and Nodular Goiter Patients NCT04482907 | Bezmialem Vakif University | N/A |
| Unknown | Application of Ultrasound Artificial Intelligence and Elastography in Differential Diagnosis of Thyroid Nodule NCT03887611 | Xin-Wu Cui | — |
| Unknown | Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules. NCT03700762 | First People's Hospital of Hangzhou | — |
| Unknown | Diagnostic Significance of CTCs in Patients With Thyroid Nodules (Circulating Tumor Cells) NCT03772496 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Completed | Effect of Three Different Peak Airway Pressures on Determining Intraoperative Bleeding in Thryroidectomies NCT03547648 | Istanbul University | N/A |
| Unknown | Thyroid Imaging Reporting and Data System (TIRADS ) Versus Thyroid Association (ATA) Guidelines NCT03517267 | Rambam Health Care Campus | — |
| Completed | Minimizing Narcotic Analgesics After Endocrine Surgery NCT03469310 | Minerva A Romero Arenas | Phase 4 |
| Recruiting | HRQOL in Thyroid Cancer and Thyroid Tumours NCT03676348 | Oslo University Hospital | — |
| Withdrawn | Evaluation of the Thyroid Volume After Radiofrequency Ablation of Thyroid Nodules and Recurrent Thyroid NCT03395925 | Olympus Surgical Technologies Europe | N/A |
| Unknown | Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy NCT03295955 | Seoul National University Hospital | N/A |
| Completed | Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules NCT03257930 | hassan harby mohamed | Phase 1 |
| Unknown | Ultrasound-guided Percutaneous Microwave Ablation for Benign Thyroid Nodules NCT03057925 | Wenjun Wu | N/A |
| Completed | HIFU Reapplication in Benign Nodules NCT03331172 | The University of Hong Kong | N/A |
| Completed | PACE4 in Thyroid Cancer NCT03160482 | Robert Day | — |
| Unknown | Fusion UltraSound Imaging Of the Thyroid GlaNd With I-124 PET. Evaluation of Nodule Allocation. NCT03128255 | Jena University Hospital | — |
| Completed | Khon Kaen University's Thyroidectomy Registry NCT03031639 | Khon Kaen University | — |
| Unknown | Relationship of Metabolic Syndrome and Its Components With Thyroid Nodule(s) NCT03009279 | Lin Liao | — |
| Unknown | Genomic Profiling of Nodular Thyroid Disease and Thyroid Cancer NCT03170804 | Aventura Hospital and Medical Center | — |
| Completed | Effectiveness of Core-Needle US Guided Biopsy as Primary Tool For Diagnosis of Thyroid Nodules NCT04759053 | Kafrelsheikh University | N/A |
| Completed | Compliance of Thyroid Fine Needle Aspiration Biopsy and Trucut Biopsy Results With TIRADS Score and Surgical P NCT04488640 | Bezmialem Vakif University | — |
| Completed | Molecular Classifier for the Fine Needle-based Assessment of Malignancy Risk in Thyroid Nodules NCT03392402 | Maria Sklodowska-Curie National Research Institute of Oncology | — |
| Completed | Skin-crease Thyroidectomy NCT04248114 | Western Galilee Hospital-Nahariya | — |
| Completed | Shared Decision Making in Patients With Thyroid Nodules NCT02878044 | Mayo Clinic | N/A |
| Completed | The Feasibility of Bilateral Intermediate Cervical Plexus Block for Thyroidectomy/Parathyroidectomy NCT04905641 | Mahidol University | — |
| Completed | Tri-modal Imaging Instrument for Thyroid Cancer NCT02758158 | University Health Network, Toronto | N/A |
| Unknown | Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules NCT02714946 | Campus Bio-Medico University | N/A |
| Completed | Red Blood Cell Distributions (RDW, RDW-CW) and Lymphocyte Monocyte Ratios (LMR) for the Malignant Thyroid Nodu NCT06283368 | Kahramanmaras Sutcu Imam University | — |
| Completed | Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules NCT03183752 | Hospital Universitário Clementino Fraga Filho | N/A |
| Completed | FDG-PET/CT in Evaluation of Cytological Indeterminate Thyroid Nodules to Prevent Unnecessary Surgery (EfFECTS) NCT02208544 | Radboud University Medical Center | N/A |
| Completed | Evaluation of the Effects of Teleconsultations on a Endocrinology Referral List NCT02710799 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Comparison of the Vocal Cord Imaging Techniques After Thyroidectomy NCT02410928 | Diskapi Teaching and Research Hospital | N/A |
| Unknown | Diagnostic Performance of Ultrasound Elastography for Detection of Thyroid Cancer NCT02462512 | Dong Jun Lim | — |
| Completed | Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules NCT02352766 | University of Pittsburgh | — |
| Completed | Delta Neutrophil Index and Neutrophil Lymphocyte Ratio in Thyroid Malignancy NCT04425512 | Kahramanmaras Sutcu Imam University | N/A |
| Unknown | Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology NCT02225509 | Diaxonhit | N/A |
| Completed | Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroide NCT02205801 | University of Chicago | N/A |
| Completed | The Diagnostic Value of Shear Wave Elastography NCT02150772 | University of Aarhus | N/A |
| Completed | microRNA in Thyroid Cancer NCT01964508 | Hadassah Medical Organization | — |
| Unknown | RFA (Radiofrequency Ablation) Versus EA (Ethanol Ablation) for Predominantly Cystic Thyroid Nodules NCT01778400 | Asan Medical Center | N/A |
| Unknown | Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules NCT01757834 | University of Washington | N/A |
| Completed | The Role of Elastography in the Diagnosis of Thyroid Nodules NCT01292044 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Terminated | Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy NCT01320813 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Unknown | Oxidized Cellulose Hemostatic Agent in Thyroid Surgery: a Prospective Randomized Controlled Study NCT01756534 | Tel-Aviv Sourasky Medical Center | N/A |
| Completed | A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery NCT01163565 | University of Alberta | N/A |
| Completed | Diagnostic Accuracy of Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular Lesions NCT03106337 | Massachusetts General Hospital | N/A |
| Completed | Percutaneous Radiofrequency Thermal Ablation in Compressive Thyroid Nodules NCT01649206 | Federico II University | Phase 3 |
| Completed | the Effect of Universal Salt Iodization on Thyroid Diseases NCT01838629 | Weimin Xu | — |
| Completed | The Role of an Optical Probe in Thyroid Cancer Diagnosis: Pilot Study NCT01792492 | Boston Medical Center | — |
| Completed | Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results NCT00858104 | Elesta S.R.L. | Phase 4 |
| Completed | Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses NCT00615537 | BioTex, Inc. | N/A |
| Completed | Levothyroxine Treatment in Thyroid Benign Nodular Goiter NCT00552253 | National Taiwan University Hospital | N/A |
| Completed | Minimal Invasiveness of Endoscopic Thyroidectomy NCT00877630 | Second Military Medical University | — |
| Completed | Reciprocating Medical Devices - a Study of a New Safety Device NCT00651625 | University of New Mexico | N/A |
| Completed | Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules NCT00571090 | Istanbul Science University | — |
| Unknown | Total Thyroidectomy With Harmonic Scalpel® NCT00385983 | Brazilian Society of Head and Neck Surgery | Phase 4 |