| Not Yet Recruiting | Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans NCT06766331 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland NCT07516912 | University of Zurich | — |
| Not Yet Recruiting | MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Con NCT07388979 | Gardiens de Vies | — |
| Not Yet Recruiting | Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections NCT06738407 | Westat | Phase 4 |
| Not Yet Recruiting | Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic NCT07317687 | West Virginia University | — |
| Recruiting | Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious NCT07300254 | Monash University | — |
| Recruiting | Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro NCT07500415 | Oswaldo Cruz Foundation | N/A |
| Completed | Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting NCT07498153 | The University of Texas Health Science Center, Houston | N/A |
| Not Yet Recruiting | Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, Uganda NCT07173764 | St George's, University of London | — |
| Recruiting | Clinical Performance Evaluation of MagIA IVD-MD Multiplex Testing (HIV/HBV/HCV/Syphilis) NCT07170748 | MagIA Diagnostics | — |
| Recruiting | The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barrie NCT06829602 | McMaster University | N/A |
| Not Yet Recruiting | Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody Test NCT06953024 | Nova Scotia Health Authority | N/A |
| Active Not Recruiting | Impact of Covid-19 on Syphilis NCT07150871 | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria | — |
| Recruiting | Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM NCT06188442 | Chinese University of Hong Kong | Phase 4 |
| Active Not Recruiting | Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Dia NCT06927843 | University of Manitoba | — |
| Recruiting | Daily Doxycycline for Early Syphillis NCT06683638 | University of Washington | Phase 2 |
| Active Not Recruiting | Ayaangwaamiziwin Initiative: Carefulness and Preparedness NCT06893159 | Unity Health Toronto | N/A |
| Not Yet Recruiting | Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergen NCT06645106 | The University of Texas Health Science Center, Houston | N/A |
| Not Yet Recruiting | A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities NCT06428643 | Tulane University | N/A |
| Recruiting | A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira I NCT06586905 | MedMira Laboratories Inc. | N/A |
| Enrolling By Invitation | Peer Delivered HIV/Syphilis Self-Testing With Assisted Partner Notification Services NCT06791928 | Makerere University | Phase 2 |
| Completed | Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection S NCT06100250 | University of Michigan | N/A |
| Completed | Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washi NCT06187064 | University of Washington | N/A |
| Recruiting | The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM) NCT05951751 | Institut de Recherche pour le Developpement | N/A |
| Completed | Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis Syphilis Ab Test at the Point- Of-Care Sit NCT06365606 | bioLytical Laboratories | N/A |
| Completed | Retrospective Study of iStatis Syphilis Ab Test (POC) NCT06367621 | bioLytical Laboratories | — |
| Completed | mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention NCT06059443 | Columbia University | N/A |
| Unknown | MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in Indonesia NCT06058286 | Yanri Wijayanti Subronto, MD, PhD, | N/A |
| Active Not Recruiting | Linezolid for Syphilis Pilot Study NCT05548426 | University of Southern California | Phase 2 |
| Completed | Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT NCT05831098 | MedMira Laboratories Inc. | N/A |
| Recruiting | Modernizing Perinatal Syphilis Testing NCT06082453 | The University of Texas Health Science Center, Houston | N/A |
| Unknown | Syphilis and HIV Point of Care Testing (POCT) in Saskatchewan NCT05863117 | Wellness Wheel Medical Clinic | N/A |
| Completed | Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Pr NCT05541081 | London School of Hygiene and Tropical Medicine | N/A |
| Completed | Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe NCT05307991 | University of North Carolina, Chapel Hill | — |
| Completed | Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY) NCT04838717 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC) NCT04793750 | Johns Hopkins University | N/A |
| Terminated | Cefixime Versus Benzathine Penicillin G in Treatment of Early Syphilis NCT06907316 | Bulovka Hospital | Phase 4 |
| Recruiting | Cefixime Clinical Trial NCT04958122 | University of Southern California | Phase 3 |
| Unknown | Interventions for Enhancing Adherence to Syphilis Treatment and Follow-up: Study Protocol for the Health Infor NCT04753125 | Hospital Moinhos de Vento | N/A |
| Completed | Impact of COVID-19 on Provision and Uptake of Prevention of Mother-to-child Transmission of HIV Services in Zi NCT04782739 | University of Zimbabwe | — |
| Completed | Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST) NCT04480749 | London School of Hygiene and Tropical Medicine | Phase 4 |
| Completed | Point of Care Tests for Syphilis and HIV NCT04514848 | University of Alberta | N/A |
| Recruiting | Vienna HIV Infection Via Sex Study NCT05326061 | Medical University of Vienna | — |
| Completed | Pre-exposure Prophylaxis: A Miracle Drug or a Moral Hazard NCT04325555 | New York University | — |
| Completed | Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users an NCT03980223 | University of California, San Francisco | Phase 4 |
| Completed | Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex with Men (DaDHS) NCT02864550 | British Columbia Centre for Disease Control | Phase 4 |
| Unknown | Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Disea NCT04084379 | Hospital de Niños R. Gutierrez de Buenos Aires | — |
| Completed | Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Witho NCT03637660 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 4 |
| Completed | Global Syphilis Sequencing NCT03709862 | London School of Hygiene and Tropical Medicine | — |
| Completed | Cefixime for Alternative Syphilis Treatment NCT03660488 | University of California, Los Angeles | Phase 2 |
| Completed | Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-nega NCT02844634 | British Columbia Centre for Disease Control | Phase 4 |
| Unknown | Transcriptomic and Next Generation Sequencing Approaches to Infection With Treponema Pallidum NCT03310424 | London School of Hygiene and Tropical Medicine | — |
| Completed | Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT NCT04947475 | Yale University | N/A |
| Unknown | The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings NCT02871505 | Peking Union Medical College Hospital | Phase 4 |
| Unknown | Finding the Latent Treponema Pallidum NCT03754517 | Peking Union Medical College Hospital | — |
| Unknown | One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis NCT02857959 | Jun Li | Phase 4 |
| Unknown | Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin NCT02884115 | Peking Union Medical College Hospital | Phase 4 |
| Completed | Texting Intervention to Sustain HIV Prevention in Women in High-drug-use Contexts NCT02447484 | University of California, San Diego | N/A |
| Completed | Evaluation of Enhanced Syphilis Screening Among HIV-positive Men NCT02019043 | Unity Health Toronto | N/A |
| Completed | Treponema Pallidum-specific Proteomic Changes in Patients With Incident Syphilis Infection NCT02059525 | Institute of Tropical Medicine, Belgium | — |
| Completed | Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia NCT02454816 | Universidad Nacional de Colombia | N/A |
| Completed | Dual Rapid HIV & Syphilis Tests in Zambia NCT02445846 | University of North Carolina, Chapel Hill | — |
| Completed | Evaluating the Effectiveness of Point-of-care Diagnostic Technologies in MCH Services in Mozambique NCT02191527 | Elizabeth Glaser Pediatric AIDS Foundation | N/A |
| Completed | Lumbar Puncture and Syphilis Outcome NCT02031146 | University of Washington | N/A |
| Completed | Implementation of a Sexual Health Intervention for Young Men Who Have Sex With Men (MSM) in Two Vietnamese Cit NCT02122094 | National Development and Research Institutes, Inc. | N/A |
| Completed | Safer Sex Program for Young African-American Men NCT01439503 | Richard Crosby | Phase 2 |
| Completed | Evaluation of the MBio Combined Syphilis/HIV Point-of-Care Diagnostic Test NCT01530672 | PATH | N/A |
| Completed | Implementation of an Efficacious Intervention for High Risk Women in Mexico NCT01465607 | University of California, San Diego | N/A |
| Completed | Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM NCT02257658 | Los Angeles LGBT Center | N/A |
| Terminated | Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. NCT01540227 | Ottawa Hospital Research Institute | — |
| Withdrawn | Evaluation of the Performance of Chembio's DPP(R) Syphilis Screen & Confirm Rapid Test System NCT01543295 | Chembio Diagnostic Systems, Inc. | — |
| Unknown | Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men NCT01300689 | Chinese Academy of Medical Sciences | — |
| Completed | A Methadone Maintenance Treatment Outcome Study in Three Provinces in China NCT01315054 | Centers for Disease Control and Prevention | N/A |
| Completed | Behavioral Science Aspects of Rapid Test Acceptance NCT01317784 | California State University, Long Beach | N/A |
| Unknown | Injecting Drug Use Community Intervention Trial NCT01108614 | National Center for AIDS/STD Control and Prevention, China CDC | Phase 3 |
| Unknown | (Men Who Have Sex With Men) MSM Community Intervention Trial NCT01068015 | National Center for AIDS/STD Control and Prevention, China CDC | Phase 3 |
| Completed | Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study NCT02611765 | Baylor College of Medicine | Phase 4 |
| Completed | Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission NCT00553111 | Jacobi Medical Center | N/A |
| Completed | Syphilis Video Tool to Promote Knowledge and Testing in the ED NCT00552539 | Jacobi Medical Center | N/A |
| Completed | Lay Health Advisors for Sexually Transmitted Disease Prevention NCT00207506 | Centers for Disease Control and Prevention | Phase 1 / Phase 2 |
| Unknown | Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and t NCT00124878 | Wawer, Maria J., M.D. | Phase 3 |
| Completed | Multi-site Study of Rapid Diagnostic Syphilis Assays NCT00300534 | Centers for Disease Control and Prevention | N/A |
| Completed | Male Circumcision for HIV Prevention in Rakai, Uganda NCT00425984 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand NCT00213057 | Population Council | Phase 1 |
| Completed | Azithromycin/Bicillin Syphilis NCT00031499 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide NCT00213031 | Population Council | Phase 2 |
| Completed | Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission NCT00213018 | Population Council | Phase 2 |
| Completed | HIV and Genital Herpes Among High-Risk Men Who Have Sex With Men (MSM) in Lima, Peru NCT00023582 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador NCT00279331 | National Institute of Allergy and Infectious Diseases (NIAID) | — |