NCT03754517

Finding the Latent Treponema Pallidum

Finding the Latent Treponema Pallidum of Syphilis With Serofast Status

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, srum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.

Detailed description

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, serum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.

Conditions

• Syphilis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	RPR Titer	RPR titer; TPPA/FTA-ABS; Next-Generation Sequencing

Timeline

• Start date: 2016-08-01
• Primary completion: 2019-11-01
• Completion: 2019-12-01
• First posted: 2018-11-27
• Last updated: 2019-03-28

Locations

1 site across 1 country: China