NCT03709862

Global Syphilis Sequencing

Whole Genome Sequencing of Syphilis Using Routine Clinical Samples

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 726 (actual)
• Sponsor: London School of Hygiene and Tropical Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches allow the whole genetic sequence of Treponema pallidum to be obtained from a swab. In this study residual DNA collected as part of routine patient care of patients seen at sexual health clinics in the UK will be used for sequencing. No patient contact is involved in the study which is limited to whole genome sequencing using residual material from samples. By better understanding the genome of the T.pallidum insights will be gained in to the pathogenesis of this important sexually transmitted disease.

Conditions

• Syphilis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Whole Genome Sequencing	Residual DNA from clinical samples will be utilised for whole genome sequencing of Treponema pallidum the causative agent of syphilis

Timeline

• Start date: 2018-10-08
• Primary completion: 2020-12-31
• Completion: 2022-02-28
• First posted: 2018-10-17
• Last updated: 2022-04-12

Locations

5 sites across 1 country: United Kingdom