| Not Yet Recruiting | Evaluation of Balance Using the Biodex Balance System Among Different Subcategories of Low Back Pain NCT07242976 | Cairo University | N/A |
| Not Yet Recruiting | Rate of Bone Union After Surgery With Stand-alone Fibergraft NCT07199075 | AO Innovation Translation Center | — |
| Completed | Facet Tropism in Low Back Pain Patients NCT06982118 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | — |
| Not Yet Recruiting | Effects of Orthosis & Exercise on Spondylolisthesis NCT06989138 | Medipol University | N/A |
| Not Yet Recruiting | Effects of a Single Session of Physiotherapy on Patients Operated for Lumbar Spondylolisthesis NCT06799975 | Istituto Clinico Humanitas | N/A |
| Completed | Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Lumbar Spondylolisthesis Surger NCT07514806 | Bangladesh Medical University | N/A |
| Recruiting | Studying Melatonin and Recovery in Teens NCT06093477 | Stanford University | N/A |
| Recruiting | Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device NCT06355791 | Spinal Simplicity LLC | N/A |
| Completed | Caudal Block Versus Quadratus Lumborum Plane Block in Lumbar Surgery NCT06398600 | Fayoum University Hospital | N/A |
| Recruiting | Evaluation of NB1 Bone Graft Following Lumbar Interbody Arthrodesis NCT03810573 | Bone Biologics Corp | N/A |
| Recruiting | ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion NCT06950853 | University Hospital, Bordeaux | — |
| Recruiting | Confirmatory Investigation to Evaluate the Performance and Safety of ReSpace TiCell Cage Implants in TLIF NCT06265038 | Sanatmetal Orthopaedic and Traumatologic Equipment Manufacturer Ltd. | N/A |
| Recruiting | The Spine PROMCO Study NCT05963815 | Park Medical centrum | — |
| Recruiting | PREventing Pain After Surgery NCT05306665 | Brigham and Women's Hospital | N/A |
| Completed | Perioperative ACT for Preventing CPSP: a Single-arm Non-randomized Pilot Trial NCT06750874 | Samantha Meints | N/A |
| Active Not Recruiting | Intercorporal Bone Graft Measurement Study NCT05565456 | Rijnstate Hospital | — |
| Active Not Recruiting | Lumbar Fusion With Porous Versus Non-Porous Cages NCT05583864 | Francis Farhadi | N/A |
| Recruiting | Comparison of Radiographic Fusion Rate and Clinical Outcome of ALIF and XLIF Performed With Either Recombinant NCT05238740 | Lindenhofgruppe AG | N/A |
| Completed | Retrospective Modulus ALIF Study NCT05566704 | NuVasive | — |
| Recruiting | Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure NCT05648474 | Alphatec Spine, Inc. | — |
| Withdrawn | Effects of a Spine Navigation System on Op-time and Radiation Exposure NCT04461964 | NYU Langone Health | N/A |
| Completed | Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery NCT05345249 | Ilse van de Wijgert | Phase 4 |
| Completed | Post-surgery Muscle Preservation and Pain Reduction Through Blood Flow Restriction Training in Orthopedic Spin NCT06962683 | University Hospital, Bonn | N/A |
| Active Not Recruiting | Clinical Outcome and Fusion Rate of 3D Printed Interbody Fusion Cages and Titanium Coated PEEK Cages NCT05237908 | Aesculap AG | — |
| Recruiting | Thoracic-Lumbar Arthrodesis- Implanet Jazz NCT05366140 | Francis Farhadi | — |
| Terminated | Spine Registration Using 3D Scanning - Arise NCT05195593 | Advanced Scanners Inc. | — |
| Recruiting | Advanced SPinal Innovations With Robotics and Enabling Technology Registry NCT05071144 | Boston Children's Hospital | — |
| Active Not Recruiting | Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages NCT05182489 | Ohio State University | N/A |
| Terminated | Spine Registration Using 3D Scanning NCT05195580 | Advanced Scanners Inc. | — |
| Active Not Recruiting | Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft. NCT04615260 | Artoss Inc. | N/A |
| Completed | A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced. NCT04416321 | Invibio Ltd | N/A |
| Completed | Erector Spinae Block vs Morphine in Vertebral Fixation NCT04729049 | AUSL Romagna Rimini | N/A |
| Enrolling By Invitation | Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF Procedures NCT04684901 | AlloSource | N/A |
| Completed | Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery NCT04637802 | Seattle Children's Hospital | N/A |
| Completed | Rehabilitation Programs in Grade I-II Spondylolisthesis NCT07419256 | Józef Piłsudski University of Physical Education | N/A |
| Completed | PMCF Study on the Safety and Performance of PROSPACE 3D / PROSPACE 3D OBLIQUE / TSPACE 3D NCT04542577 | Aesculap AG | — |
| Completed | PMCF Study on the Safety and Performance of CESPACE 3D NCT04477447 | Aesculap AG | — |
| Unknown | SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2 NCT04566874 | Camber Spine Technologies | N/A |
| Completed | Spine Ultrasound Image Study of Spondylolisthesis Patient NCT04426916 | Seoul National University Hospital | — |
| Unknown | Randomized Control Trial of Quadratus Lumborum Block for Lumbar Spine Decompression and Fusion Surgery NCT04447950 | Assuta Medical Center | N/A |
| Completed | Bilateral Erector Spinae Plane Block Versus Local Anesthetic Infiltration for Perioperative Analgesia in Spine NCT04123106 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | MLX/XLX ACR Expandable Lumbar Interbody Implants NCT04420143 | NuVasive | — |
| Completed | Quintex® Follow-up After One Year Minimum NCT04489394 | Aesculap AG | — |
| Active Not Recruiting | PMCF Neo Pedicle Screw and Cage Systems NCT03956537 | Neo Medical SA | — |
| Withdrawn | A Study Evaluating 3-Level OLIF Spine Fusion NCT03896347 | Elutia Inc. | — |
| Completed | Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery NCT03754972 | Medical Metrics Diagnostics, Inc | N/A |
| Completed | Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT NCT03884283 | Prosidyan, Inc. | N/A |
| Completed | Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum NCT03945461 | Mayo Clinic | N/A |
| Terminated | Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery NCT04007094 | Ohio State University | N/A |
| Withdrawn | Clinical Evidence of Robot Guided vs. Navigated vs. Free Hand Lumbar Spinal Fusion NCT02998060 | Marc Schröder | N/A |
| Completed | Comparison Of A Novel Hand-held Retractor-Assisted Transforaminal Lumbar Interbody Fusion By The Wiltse Approa NCT06052579 | Nanfang Hospital, Southern Medical University | N/A |
| Active Not Recruiting | The European Robotic Spinal Instrumentation (EUROSPIN) Study NCT03398915 | Marc Schröder | — |
| Enrolling By Invitation | The Course of Hip Flexion Weakness Following LLIF or ALIF NCT04204135 | Rush University Medical Center | — |
| Recruiting | Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine S NCT03883022 | Taipei Veterans General Hospital, Taiwan | N/A |
| Enrolling By Invitation | Advanced Materials Science in XLIF Study NCT03649490 | NuVasive | — |
| Withdrawn | Peri-Incisional Drug Injection in Lumbar Spine Surgery NCT03513445 | University of Minnesota | Phase 3 |
| Completed | ViBone in Cervical and Lumbar Spine Fusion NCT03425682 | Elutia Inc. | — |
| Completed | Evaluation of 3D Machine-vision Image Guided Surgery Spine Navigation NCT03968965 | 7D Surgical Inc. | N/A |
| Completed | Retest-reliability and At-home-assessment Feasibility of the 5R-STS NCT03321357 | Bergman Clinics | — |
| Completed | BIO4 Clinical Case Study: Cervical Spine NCT03077204 | Seton Healthcare Family | Phase 4 |
| Unknown | Burst Biologics Spinal Fusion Registry NCT03064802 | Burst Biologics | — |
| Completed | Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolis NCT03100032 | Novadip Biosciences | Phase 1 / Phase 2 |
| Terminated | Prospective Follow-up of Elderly Patients Undergoing Instrumented Lumbar Arthrodesis Supplemented by the Impla NCT03434223 | Ohio State University | — |
| Terminated | A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative P NCT03514277 | Virtua Health, Inc. | Phase 4 |
| Completed | Transverse Abdominis Plane Block for Anterior Approach Spine Surgery NCT02884440 | Rennes University Hospital | Phase 2 |
| Unknown | Supine vs. Upright Weight Bearing MRI in the Evaluation of Patients With Lumbar Spondylolisthesis NCT02958241 | Texas Back Institute | N/A |
| Unknown | Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device NCT02805985 | Expanding Orthopedics Ltd. | N/A |
| Completed | PASS OCT® Post-market Clinical Follow-up NCT02931279 | Medicrea International | — |
| Completed | Validation of Appropriateness Criteria for the Surgical Treatment of Lumbar Degenerative Spondylolisthesis NCT02966639 | Dartmouth-Hitchcock Medical Center | — |
| Completed | Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain NCT02861456 | Nationwide Children's Hospital | N/A |
| Unknown | Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion NCT02854904 | Sarah Network of Rehabilitation Hospitals | Phase 2 / Phase 3 |
| Completed | Assessing the Diagnostic Accuracy of Corrected Flow Time (FTc) and Pleth Variability Index (PVI) as Predictors NCT02826889 | Yonsei University | N/A |
| Completed | Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion NCT02628210 | RTI Surgical | N/A |
| Unknown | Study of Nucel for One and Two Level Lumbar Interbody Fusion NCT02808234 | Organogenesis | N/A |
| Completed | A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP® NCT02225444 | Bioventus LLC | — |
| Completed | New Robotic Assistance System for Spinal Fusion Surgery NCT02558621 | KB Medical SA | N/A |
| Completed | Effect of Pregabalin on Immediate Post-operative and Longterm Pain NCT02464813 | Turku University Hospital | Phase 4 |
| Unknown | Decompression vs. Fusion for Stable Degenerative Spondylolisthesis NCT02348645 | University Health Network, Toronto | N/A |
| Terminated | Instrumented Thoracic and Lumbar Arthrodesis Supplemented by the Implanet Jazz SystemTMd NCT02411799 | Ohio State University | — |
| Terminated | A Prospective Study of NuCel® in Cervical Spine Fusion NCT02381067 | NuTech Medical, Inc | N/A |
| Terminated | UNiD Rods Register NCT02926404 | Medicrea International | — |
| Completed | Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis NCT02332200 | Nationwide Children's Hospital | — |
| Unknown | Post-market Study of the TOPS™ System NCT02234154 | Premia Spine | N/A |
| Terminated | Clinical Evaluation of GENEX® DS in Instrumented Posterolateral Fusion NCT02317185 | Spine Wave | — |
| Unknown | MIS ReFRESH: Robotic vs. Freehand Minimally Invasive Spinal Surgeries NCT02057744 | Mazor Robotics | — |
| Terminated | Evaluation of Fusion Rate Using K2M VESUVIUS® Demineralized Fibers With K2M EVEREST® Spinal System NCT02064855 | K2M, Inc. | — |
| Completed | A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery NCT02252185 | Johnson & Johnson Medical (Suzhou) Ltd. | N/A |
| Unknown | Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fus NCT02171169 | Baxano Surgical, Inc. | — |
| Unknown | Post-market Study of the TOPS™ System NCT01933607 | Premia Spine | N/A |
| Terminated | Slump Sitting X-ray of the Lumbar Spine Is Better Than Conventional Flexion View NCT02547324 | National University Hospital, Singapore | N/A |
| Terminated | Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Diseas NCT02070484 | OhioHealth | N/A |
| Completed | Safety and Efficacy of the CarboFix Pedicle Screw System NCT02039232 | CarboFix Orthopedics Ltd. | N/A |
| Completed | Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine NCT02023372 | NuTech Medical, Inc | N/A |
| Completed | Effects of Exercise Intervention in Patients With Spondylolisthesis Related LBP NCT01985776 | University of Primorska | N/A |
| Completed | A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures NCT01972256 | Baxano Surgical, Inc. | — |
| Completed | Assessment of nanOss Bioactive 3D in the Posterolateral Spine NCT01829997 | Pioneer Surgical Technology, Inc. | N/A |
| Terminated | Efficacy of Hybrid Systems in Comparison to the Rigid Spondylodesis in Lumbar-spine Fusion NCT01852526 | University of Cologne | N/A |
| Suspended | Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion NCT03726190 | Tristate Brain and Spine Institute | — |
| Completed | The Addition of a Pilates Program for Short-Term Improvements in Patients With Spondylolysis or Spondylolisthe NCT01711203 | Megan Donaldson PT, PhD, FAAOMPT | N/A |
| Unknown | Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain NCT01918943 | American British Cowdray Medical Center | — |
| Terminated | RAMP Study: A Study Comparing Two Lumbar Fusion Procedures NCT01716182 | Baxano Surgical, Inc. | — |
| Completed | Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis NCT01455805 | Spinal Simplicity LLC | N/A |
| Terminated | Aspen Spinous Process Fixation System for Use in PLF in Patients With Spondylolisthesis NCT01560273 | Zimmer Biomet | — |
| Terminated | A Postmarket Surveillance Study of the Paradigm Spine Dynamic Stabilization System (DSS) NCT01461005 | Paradigm Spine | N/A |
| Unknown | Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression NCT01338766 | Baxano Surgical, Inc. | N/A |
| Unknown | Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine NCT01224379 | University of Cologne | N/A |
| Terminated | Effectiveness of Lumbar Fusion When NanOss Bioactive Is Used With Posterolateral Gutter Fusions NCT01452516 | Pioneer Surgical Technology, Inc. | N/A |
| Terminated | CopiOs Posterolateral Fusion Procedure NCT01123850 | Zimmer Biomet | Phase 2 |
| Completed | Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spin NCT01968993 | Pioneer Surgical Technology, Inc. | N/A |
| Unknown | Prospective Study of Minimally Invasive Spine Surgery NCT01045473 | Society for Minimally Invasive Spine Surgery | — |
| Completed | Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia NCT01325493 | Julia Finkel | Phase 4 |
| Completed | XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Cent NCT01024699 | NuVasive | — |
| Unknown | Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (D NCT00798902 | BioSurface Engineering Technologies, Inc | Phase 1 / Phase 2 |
| Unknown | Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD NCT00798239 | BioSurface Engineering Technologies, Inc | Phase 1 / Phase 2 |
| Terminated | Clinical Outcomes of the Trinica(R) Anterior Lumbar Plate: Fixed Screws vs. Variable Screws NCT00762723 | Zimmer Biomet | N/A |
| Completed | Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fus NCT00549913 | Mesoblast, Ltd. | Phase 1 / Phase 2 |
| Completed | Spine Research With Roentgen Stereophotogrammetric Analysis NCT00493558 | Nova Scotia Health Authority | Phase 4 |
| Completed | Spine Fusion Instrumented With BMP-2 vs Uninstrumented With Infuse BMP-2 Alone NCT00405600 | Nova Scotia Health Authority | N/A |
| Completed | Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviat NCT00405691 | Impliant, Ltd. | Phase 3 |
| Completed | Posterior Lateral Fusion (PLF) With Dynesys NCT00791180 | Zimmer Biomet | — |
| Terminated | Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix NCT00254852 | Exactech | N/A |
| Unknown | Total Facet Arthroplasty System®(TFAS®) Clinical Trial NCT00418197 | Archus Orthopedics, Inc. | Phase 3 |
| Terminated | Vertebral Osteosynthesis in Degenerative Lumbar Stenosis With Spondylolisthesis NCT00252551 | University Hospital, Toulouse | N/A |
| Terminated | Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device NCT00095095 | Medtronic Spinal and Biologics | Phase 4 |
| Completed | Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion NCT00205101 | University of Wisconsin, Madison | — |
| Completed | Greenwich Lumbar Stenosis SLIP Study NCT00109213 | Greenwich Hospital | Phase 3 |
| Completed | Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis NCT00000409 | Dartmouth-Hitchcock Medical Center | Phase 4 |