| Withdrawn | A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders NCT05974293 | Michael, Levy M.D.,Ph.D. | Phase 2 |
| Not Yet Recruiting | Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury NCT06290609 | Stanford University | N/A |
| Completed | How Stroke Affects Leg Muscles When Walking NCT07504627 | University Hospital, Limoges | — |
| Completed | Investigation of the Effects of Upper Extremity Botulinum Toxin Application on Forearm Muscle Thickness and Mo NCT07083752 | Abant Izzet Baysal University | — |
| Active Not Recruiting | Effect of Transcutaneous Auricular Nerve Stimulation vs Body Rocking Exercises on Spasticity of Upper Limb NCT06914115 | Superior University | N/A |
| Not Yet Recruiting | Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury NCT06532760 | Assistance Publique Hopitaux De Marseille | N/A |
| Recruiting | FlexWave Trial: Efficacy of Extracorporeal Shock Wave Therapy in Post-Stroke Upper Limb Spasticity NCT06365476 | National Taiwan University Hospital | N/A |
| Completed | Analysis of the Correlation Between Ultrasound Imaging and Functional Parameters in the Medial Gastrocnemius M NCT06411587 | Universidad de Zaragoza | — |
| Recruiting | Study of Brain-spinal Cord Neural Connectivity in Spasticity NCT06281223 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Recruiting | Investıgatıon Of The Effectıveness Of The Mollıı Suıt In Chıldren Wıth Ambulatory Cerebral Palsy NCT06109129 | Kastamonu University | N/A |
| Unknown | EXOPULSE Mollii Suit, Motor Function & Stroke (EXOSTROKE 2) NCT06214975 | Sheikh Shakhbout Medical City | N/A |
| Recruiting | Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy NCT06070233 | Ohio State University | N/A |
| Recruiting | Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning NCT05094362 | Medical University of South Carolina | N/A |
| Withdrawn | The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Mo NCT05887479 | Sisli Hamidiye Etfal Training and Research Hospital | Phase 4 |
| Unknown | EXOPULSE Mollii Suit, Spasticity, Muscular Oxygenation & Multiple Sclerosis (ENNOX 2) NCT05912595 | Sheikh Shakhbout Medical City | N/A |
| Recruiting | EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis (EXOSEP 2) NCT05857280 | Sheikh Shakhbout Medical City | N/A |
| Recruiting | Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP NCT05518188 | Elpida Therapeutics SPC | Phase 1 / Phase 2 |
| Unknown | Effect of Cryoneurolysis on Pain in Patients With Hand Contracture. NCT06051656 | Vancouver Island Health Authority | — |
| Completed | Effects of PNF and Static Stretching on Architecture and Viscoelastic Properties of Hemiplegic Elbow NCT05626790 | Istanbul University - Cerrahpasa | N/A |
| Completed | REHABOTICS: Integrated Rehabilitation System for People With Motor Disabilities NCT06519630 | Pantelis Syringas | N/A |
| Unknown | Performance and Long-term Safety of FlowOx2.0™, Multiple Sclerosis, Spasticity and Pain NCT05598736 | Otivio AS | N/A |
| Unknown | Performance and Long-term Safety of FlowOx2.0™ in Patients With Multiple Sclerosis - Impact on Spasticity and NCT05562453 | Otivio AS | N/A |
| Completed | Changes in Pain, Spasticity, and Quality of Life After Use of Counterstrain Treatment in Individuals With SCI NCT05559255 | William Carey University | N/A |
| Completed | Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury NCT05432999 | Kessler Foundation | N/A |
| Recruiting | Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury NCT05457205 | University of Mississippi Medical Center | N/A |
| Completed | Multiphasic Neuroplasticity Based Training Protocol With Shock Wave Therapy For Post Stroke Spasticity NCT05405140 | Riphah International University | N/A |
| Recruiting | Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity NCT05226637 | University of Alberta | N/A |
| Recruiting | Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) NCT05354622 | Boston Children's Hospital | — |
| Unknown | Individualized rTMS Based on fNIRS to Spasticity NCT05318586 | First Affiliated Hospital Xi'an Jiaotong University | N/A |
| Suspended | Robotic Interventions for Spasticity Treatment NCT05006248 | Shirley Ryan AbilityLab | N/A |
| Completed | Efficacy of Extracorporeal Shock Wave Therapy on Spasticity NCT06225024 | Kayseri City Hospital | N/A |
| Completed | DDN in Stroke--COBRE NCT05196737 | Medical University of South Carolina | N/A |
| Unknown | The Effect of Speed-based Training on Spasticity and Balance NCT05256030 | Suleyman Demirel University | N/A |
| Active Not Recruiting | Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity NCT05429736 | Shepherd Center, Atlanta GA | N/A |
| Unknown | Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin( NCT05151874 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin NCT05103202 | University of Texas Southwestern Medical Center | — |
| Completed | Focal Muscular Vibration in Patients with Severe Acquired Brain Injury NCT05464160 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Unknown | Neurophysiological Evaluation of Muscle Tone NCT05070780 | Neuromed IRCCS | — |
| Recruiting | Obturator Cryoneurotomy for Hip Adductor Spasticity NCT05147441 | Vancouver Island Health Authority | — |
| Completed | Shock Wave Therapy for Management of Spasticity in Patients With Cerebral Palsy NCT05702606 | Fundacio Aspace Catalunya | N/A |
| Unknown | Pilot Investigation to Evaluate FlowOx2.0™ for Experimental Treatment of Spasticity NCT04904016 | Otivio AS | N/A |
| Completed | Effect of Tecar in Addition of Functional Massage in Post-stroke Spasticity NCT04824768 | Universitat Internacional de Catalunya | N/A |
| Completed | Effects of CRet Associated With Functional Massage (F.M) on Gait and Functionality in Post-stroke Spasticity NCT04851756 | Universitat Internacional de Catalunya | N/A |
| Completed | Extracorporeal Shock Wave Therapy and Assessment Strategy Through a Novel Gait Analysis Tool for Post-stroke S NCT05206240 | Carol Davila University of Medicine and Pharmacy | — |
| Completed | Physiological Changes Induced Through MEP Conditioning in People With SCI NCT04286191 | Medical University of South Carolina | N/A |
| Completed | Comparison Between Unihemispheric and Bihemispheric TCDS in Subacute Ischemic Stroke Patients NCT04770363 | Alexandria University | N/A |
| Unknown | Efficacy of Dry Needling in the Spasticity Post-stroke NCT04435561 | University of Malaga | N/A |
| Unknown | Can Transcutaneous Electrical Stimulation Garment Improve Gait in Children With Cerebral Palsy? NCT04715334 | KK Women's and Children's Hospital | N/A |
| Unknown | RGS@Home: Personalized 24/7 Home Care Post-stroke NCT04620707 | Institute for Bioengineering of Catalonia | N/A |
| Completed | Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury NCT05687097 | University Health Network, Toronto | — |
| Unknown | Using Shear Wave Ultrasound Elastography for Follow up After Anti-spastic Intervention Among Stroke Patients NCT04550793 | National Taiwan University Hospital | — |
| Recruiting | Extracorporeal Shock Wave Therapy on Spastic Equinus Foot in Stroke Patients NCT06547684 | Teresa Mateu Campos | N/A |
| Unknown | Multimodal Instrumented Assessment of Post-stroke Elbow NCT04484571 | Azienda USL Toscana Nord Ovest | N/A |
| Terminated | Early Radial Shock Waves Treatment on Spasticity in Patients With Stroke in Sub-acute Phase NCT04365478 | Stefano Brunelli | N/A |
| Unknown | Quantifying Muscle Tone in Patients With Brain Injury - a Feasibility Study NCT04207632 | Rigshospitalet, Denmark | — |
| Completed | Effect of Session Frequency of rESWT on Gastrocnemius Muscle Spasticity in Children With Spastic Type Cerebral NCT04574622 | Rizky Kusuma Wardhani | N/A |
| Completed | Effect of Number of Pulses of Radial Extracorporeal Shock Wave Therapy on Hamstring Spasticity in Children Wit NCT04546035 | Rizky Kusuma Wardhani | N/A |
| Withdrawn | Effects of Baclofen on Presynaptic Inhibition in Humans NCT04471714 | University of Alberta | Phase 2 |
| Completed | Validity and Reliability Study of the Muscle Excitability Scale in Spinal Cord Injury Patients NCT04266964 | University Hospital, Motol | — |
| Unknown | Efficiency of the Super Inductive System in Spasticity Treatment NCT04190238 | Iuliu Hatieganu University of Medicine and Pharmacy | N/A |
| Completed | Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injur NCT04130295 | Shepherd Center, Atlanta GA | N/A |
| Completed | Assessment of the Excitability of Spinal Motoneurons Using Stimulus-response Curves of the Bulbocavernosus Ref NCT04022187 | Pierre and Marie Curie University | — |
| Terminated | Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products NCT03886753 | Children's Hospital of Philadelphia | — |
| Completed | Long-term Efficacy of Spasticity-correcting Surgery and Botulinum Toxin Injections for Upper Limb Spasticity T NCT03910101 | Vastra Gotaland Region | N/A |
| Terminated | Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity NCT03815721 | Swiss Paraplegic Research, Nottwil | N/A |
| Completed | Validation of the Spasticity Related Quality of Life Questionnaire NCT03442660 | Ipsen | N/A |
| Unknown | " Treating MS Patients With Lower Extremity Spasticity Using Dysport" NCT03585569 | Neurology Center of New England P.C. | Phase 3 |
| Completed | A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity D NCT03319732 | RVL Pharmaceuticals, Inc. | Phase 3 |
| Completed | Dry Needling in Stroke in Sub-Acute Phase to Improve Upper Limb NCT03462693 | Guadarrama Hospital | — |
| Completed | Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity NCT03209960 | Vanderbilt University Medical Center | — |
| Completed | Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility NCT03250988 | Vanderbilt University Medical Center | — |
| Completed | Using Telemedicine to Improve Spasticity Diagnosis Rates NCT03211390 | Vanderbilt University Medical Center | — |
| Completed | A Study to Investigate the Safety and Effectiveness of Arbaclofen Extended-Release Tablets for Patients With M NCT03290131 | RVL Pharmaceuticals, Inc. | Phase 3 |
| Completed | Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients NCT03342820 | University Hospital, Lille | N/A |
| Enrolling By Invitation | Effect of Treatment Dairy for Spasticity NCT03384927 | Rigshospitalet, Denmark | — |
| Completed | Dry Needling and Botulinum Toxin in the Management of Poststroke Spasticity NCT03747900 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | N/A |
| Completed | Medical Spastic Patient Machine Interface MSPMI : Biomechanical and Electrophysiological Assessment of the Tri NCT03307135 | Nantes University Hospital | N/A |
| Completed | Effects of Using the Electrodress Mollii on Spasticity NCT04076878 | Danderyd Hospital | N/A |
| Completed | Medtronic PSR TDD PMCF NCT04714385 | Medtronic | — |
| Completed | Antagonist Activation Measurement at the Ankle Using High-density and Bipolar Surface EMG in Chronic Hemipares NCT06099132 | Henri Mondor University Hospital | — |
| Completed | Sensorimotor Changes in Stroke Following Mindfulness NCT03534856 | University of Southern California | N/A |
| Completed | Muscle Spasticity Reduction in Children With Cerebral Palsy by Means of Hippotherapy NCT03212846 | University of Cadiz | N/A |
| Completed | Dry Needling in Stroke to Improve the Upper Limb Functionality NCT03248986 | Guadarrama Hospital | — |
| Completed | Efficacy Of Platelet Rich Plasma In The Treatment Of Hemiplegıc Shoulder Pain NCT03931824 | Ege University | N/A |
| Completed | Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC NCT03797573 | University of Liege | Phase 1 |
| Completed | MEDITOXIN® Treatment in Subjects With Post-Stroke Upper Limb Spasticity NCT03908580 | Medy-Tox | Phase 4 |
| Recruiting | The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies. NCT05518565 | Eva Ponten | — |