NCT05318586

Individualized rTMS Based on fNIRS to Spasticity

Effect of Individualized rTMS Based on fNIRS on the Upper Limb Spasticity After Stroke

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: First Affiliated Hospital Xi'an Jiaotong University · Academic / Other
• Sex: All
• Age: 40 Years – 79 Years
• Healthy volunteers: Accepted

Summary

Stroke is of high morbidity and mortality, and surviving patients are often unable to take care of themselves because of severe motor dysfunction. The brain has plasticity, and makes adaptive changes after stroke, resulting in the reorganization and compensation of neural networks. However, the muscle tone of some patients will significantly increase during the recovery process, which affects the rehabilitation effect. Neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) have been widely used to promote brain network remodeling after stroke. The investigators attempted to evaluate the motor brain network characteristics of spastic patients by fNIRS, and used the most active brain regions as rTMS stimulation regions to evaluate the improvement effect of this individualized treatment on post-stroke spasticity.

Conditions

• Stroke
• Spasticity, Muscle
• Rehabilitation

Interventions

Type	Name	Description
PROCEDURE	individual rTMS based on fNIRS	The rTMS parameters will be set according to fNIRS results.
PROCEDURE	Traditional rTMS strategy	The low-frequency rTMS to contralesional M1 will always be used.

Timeline

• Start date: 2022-04-10
• Primary completion: 2023-09-01
• Completion: 2023-12-31
• First posted: 2022-04-08
• Last updated: 2022-04-20

Locations

1 site across 1 country: China