| Not Yet Recruiting | A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop NCT07146048 | Children's Hospital Medical Center, Cincinnati | Phase 3 |
| Not Yet Recruiting | Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor NCT07078357 | University of Sao Paulo General Hospital | Phase 1 / Phase 2 |
| Not Yet Recruiting | Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status NCT07146282 | Ahmed Hassan Rostom Ibrahim | — |
| Not Yet Recruiting | Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice NCT07068633 | Yonsei University | — |
| Not Yet Recruiting | Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Hear NCT07065474 | Kathmandu Institute of Child Health | N/A |
| Recruiting | Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE NCT06952374 | Prince of Wales Hospital, Shatin, Hong Kong | N/A |
| Completed | Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy NCT06150274 | Helse Stavanger HF | N/A |
| Recruiting | Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda NCT05783375 | Children's Hospital Medical Center, Cincinnati | N/A |
| Unknown | Non-Expert Acquisition & Remote Expert Review of Screening Echocardiography Images From Child Health & AnteNat NCT06002243 | Menzies School of Health Research | N/A |
| Unknown | Gliflozins on HF in Regurgitant Rheumatic Heart NCT06097585 | Assiut University | — |
| Active Not Recruiting | GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial NCT05693545 | Children's Hospital Medical Center, Cincinnati | Phase 2 |
| Completed | Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System NCT05668611 | Children's Hospital Medical Center, Cincinnati | N/A |
| Unknown | Dapagliflozin Effect on Rheumatic Mitral Stenosis NCT05618223 | Universitas Sebelas Maret | Phase 3 |
| Recruiting | Screening and Secondary Prevention Rheumatic Heart Disease Study NCT05991219 | National Institute of Cardiovascular Diseases, Pakistan | — |
| Completed | Case Management and Peer Support Groups for Prophylaxis Adherence in Rheumatic Heart Disease NCT05502042 | Children's Hospital Medical Center, Cincinnati | N/A |
| Unknown | Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass NCT05487469 | Nanjing Medical University | N/A |
| Recruiting | Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease NCT05504928 | Insel Gruppe AG, University Hospital Bern | N/A |
| Active Not Recruiting | Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression NCT04575857 | University of Washington | — |
| Completed | Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET" NCT05276999 | Children's Hospital Medical Center, Cincinnati | N/A |
| Completed | A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post) NCT05211024 | Children's Hospital Medical Center, Cincinnati | — |
| Withdrawn | INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiori NCT02832531 | Population Health Research Institute | Phase 3 |
| Active Not Recruiting | Echocardiographic Screening of Pregnant Women During Antenatal Care NCT04936815 | Thomas Pilgrim | N/A |
| Unknown | The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients NCT03991910 | Indonesia University | Phase 3 |
| Terminated | RIvoraxaban in Mitral Stenosis NCT03926156 | Rajaie Cardiovascular Medical and Research Center | Phase 3 |
| Active Not Recruiting | Rheumatic Heart Disease Research and Screening in Nepal: A Feasibility Study NCT05250154 | University of Washington | — |
| Unknown | Determining the Impact of Penicillin in Latent RHD: The GOAL Trial NCT03346525 | Children's National Research Institute | Phase 2 |
| Unknown | Right Ventricular Echo Assessment in Mitral Valve Replacement NCT03549052 | Assiut University | — |
| Unknown | Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge NCT03156972 | Mohammed mahmoud mohammed othman | N/A |
| Completed | INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Infer NCT02832544 | Population Health Research Institute | Phase 3 |
| Recruiting | The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic H NCT04556188 | Helse Nord-Trøndelag HF | — |
| Completed | Rheumatic Heart Disease Study in Lusaka NCT02661763 | University of Zambia | — |
| Completed | Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enla NCT02474108 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Completed | Mobile Health in Structural Heart Disease NCT02881398 | Sri Sathya Sai Institute of Higher Medical Sciences | Phase 2 / Phase 3 |
| Completed | The Genetic Basis of Acquired Heart Disease in Africa NCT02124109 | National Human Genome Research Institute (NHGRI) | — |
| Completed | Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren NCT02353663 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | RhEumatiC Heart diseAse Genetics NCT02118818 | Brigham and Women's Hospital | — |
| Completed | Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery NCT01794884 | Yuejiang Liu | Phase 2 |
| Completed | Rheumatic Heart Disease School Project NCT01550068 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region NCT02188862 | University of Oxford | — |
| Completed | Effect of Simvastatin on Cardiac Function NCT01178710 | Sun Yat-sen University | N/A |
| Unknown | The Prevalence of Rheumatic Heart Disease in School Children in Fiji NCT00779662 | Queensland Institute of Medical Research | — |
| Completed | Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease NCT00482573 | University of Sao Paulo | Phase 1 |
| Completed | DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease NCT00264524 | China Medical University Hospital | N/A |