Trials / Recruiting
RecruitingNCT05783375
Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 221 (estimated)
- Sponsor
- Children's Hospital Medical Center, Cincinnati · Academic / Other
- Sex
- All
- Age
- 5 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.
Detailed description
ADUNU is a non-randomized experiment, testing a strategy for implementing an evidence-based practice, decentralized RHD preventive services. The objectives of the study are to: Objective 1: Demonstrate the impact of ADUNU, using the RE-AIM framework to assess program Reach, Effectiveness, Adoption, Implementation and Maintenance. Objective 2: Estimate the cost-effectiveness and budget impact of ADUNU. ADUNU is a public health initiative that will be deployed the Uganda ministry of health in partnership with the District Health Offices (DHO) in two districts. The program will be overseen by the Technical and Quality Assurance (TAQA). ADUNU's main components will include a RHD testing program which consists of community and facility based echocardiographic screening of children and young adults and a registry based secondary prophylaxis injections of Benzathine penicillin G (BPG) at local health centers III and IVs in both districts.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | ADUNU program for delivery of RHD care services | The ADUNU program will be deployed by the Ugandan Ministry of Health and the involved District Health Offices to include echocardiography integrated into primary healthcare to screen for RHD and a registry-based care system to keep patients linked to care and prophylaxis. |
Timeline
- Start date
- 2024-05-01
- Primary completion
- 2027-01-31
- Completion
- 2028-01-31
- First posted
- 2023-03-24
- Last updated
- 2025-06-13
Locations
1 site across 1 country: Uganda
Source: ClinicalTrials.gov record NCT05783375. Inclusion in this directory is not an endorsement.