| Completed | Automated Screening Device to Detect MTMROP NCT06517836 | Siloam Vision | N/A |
| Recruiting | Imaging Retinal Vasculature in Infant Eyes NCT05558059 | Duke University | — |
| Recruiting | Impact of Standardized Skin-to-Skin Care on Clinical Outcomes in Infants Born ≤ 32 Weeks: A Multicenter Study NCT06672913 | Baskent University Ankara Hospital | N/A |
| Active Not Recruiting | Validation of i-ROP DL to Detect More Than Mild ROP NCT06109285 | Siloam Vision | N/A |
| Not Yet Recruiting | Reducing Pain and Increasing Comfort During a Retinopathy of Prematurity Examination NCT06348641 | Nurgül Tekin | N/A |
| Recruiting | An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Us NCT06315556 | Bayer | — |
| Completed | Comfort Level in Premature Infants Undergoing Retinopathy of Prematurity Screening NCT07016984 | Istanbul Nisantasi University | N/A |
| Unknown | Peripheral Avascular Retina in Retinopathy of Prematurity NCT06044181 | Assiut University | N/A |
| Unknown | NeO2Matic-Pilot Trial NCT05629910 | Rigshospitalet, Denmark | N/A |
| Recruiting | Intranasal Dexmedetomidine for Pain Management During Screening for Retinopathy of Prematurity NCT06067958 | Assaf-Harofeh Medical Center | Phase 3 |
| Recruiting | Evaluation of the Frequency, Risk Factors, and Outcomes of ROP in Infants With a BW >1500 Grs or GA ≥33 Wks in NCT06265363 | Baskent University Ankara Hospital | — |
| Unknown | The Effect of Different Music Listened During Retinopathy Examination to Premature Infants NCT05967572 | Necmettin Erbakan University | N/A |
| Recruiting | A Study to Collect Data on the Use of Eylea in Babies Born Too Early Who Have a Condition of the Eye Where Blo NCT05705258 | Bayer | — |
| Completed | A 24-week Study Evaluating the Effectiveness and Safety of Lucentis® 0.2mg in Retinopathy of Prematurity Parti NCT05576792 | Novartis Pharmaceuticals | — |
| Completed | Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of NCT06461975 | Alexandria University | Phase 3 |
| Recruiting | Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity NCT03083431 | University of Zurich | Phase 2 |
| Unknown | Real World Study of the Effectiveness and Safety of Conbercept Ophthalmic Injection in the Treatment of Retino NCT04985448 | Chengdu Kanghong Biotech Co., Ltd. | — |
| Completed | A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose E NCT06288321 | The University of Hong Kong | EARLY_Phase 1 |
| Completed | Regulatory PMS Study for Lucentis® in Patients With Retinopathy of Prematurity NCT05304949 | Novartis Pharmaceuticals | — |
| Recruiting | Pharmacokinetics and Safety of Dexamethasone Eye Drops in Preterm Infants NCT05387941 | Region Skane | Phase 1 |
| Active Not Recruiting | Bevacizumab Treatment For Type 1 ROP NCT04634578 | Jaeb Center for Health Research | Phase 2 |
| Completed | Iron and Retinopathy of Prematurity (ROP) NCT05133999 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | A Randomized Trial of Low-Dose Bevacizumab vs Laser for Type 1 ROP NCT04634604 | Jaeb Center for Health Research | Phase 3 |
| Unknown | Clonidine as Pain Relief During ROP Eye Examinations NCT04902859 | Region Örebro County | Phase 4 |
| Completed | Improve Screening Criteria for Retinopathy of Prematurity in Two French Center NCT05152862 | Centre Hospitalier Sud Francilien | — |
| Completed | umBilical Or Adult Donor Red Blood Cells in Extremely Low Gestational Age Neonates and Retinopathy of Prematur NCT05100212 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Phase 2 |
| Completed | Efficacy and Safety of Mydriatic Microdrops for Retinopathy Of Prematurity Screening NCT05043077 | Aristotle University Of Thessaloniki | Phase 4 |
| Completed | Prematurity and Ophthalmological Changes NCT06452524 | Ankara City Hospital Bilkent | — |
| Recruiting | Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2) NCT04995341 | Duke University | N/A |
| Recruiting | European Disease Registry on Retinopathy of Prematurity (ROP) NCT04939571 | University Medicine Greifswald | — |
| Completed | Feasibility of Nurse-led Retinal Imaging for Retinopathy of Prematurity Screening Employing the Optos Californ NCT06063863 | University of Nottingham | N/A |
| Completed | Mother Milk as a Eye Drop & Premature Retinopathy NCT04883931 | Baskent University | N/A |
| Completed | The Effects of Mydriatic Eye Drops in Retinopathy of Prematurity Examinations NCT05880433 | Istanbul Training and Research Hospital | — |
| Unknown | Role of Cord Blood Cytokines and Perinatal Factors in Prediction of Retinopathy of Prematurity NCT04769661 | Assiut University | — |
| Unknown | The Effect of Cycled Light on Premature Infants and Mothers NCT05010252 | National Taiwan University Hospital | N/A |
| Unknown | Genetic Polymorphism and Retinopathy of Prematurity: Correlation of Clinical Presentations and Severity NCT05132257 | Chang Gung Memorial Hospital | — |
| Active Not Recruiting | Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopath NCT04515524 | Regeneron Pharmaceuticals | — |
| Unknown | Eye Shields for Infants After Dilated Exam NCT04519060 | Children's Hospital Los Angeles | N/A |
| Completed | Intravitreal Ranibizumab Injection for Aggressive Versus Type 1 Prethreshold Retinopathy of Prematurity NCT05701124 | Zagazig University | Phase 3 |
| Completed | PhaseI/II Investigator-Initiated Trial to Investigate Safety and Efficacy of Ripasudil in Patients With Retino NCT04621136 | Kyushu University | Phase 1 / Phase 2 |
| Unknown | The Analysis of Association of Retinopathy of Prematurity, Gut Microbiome Profile, and Systemic Inflammation NCT05144282 | Chang Gung Memorial Hospital | — |
| Completed | The Incidence of Treatment-requiring Retinopathy of Prematurity in Greece NCT05099588 | Aristotle University Of Thessaloniki | — |
| Completed | Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) NCT04623684 | Aristotle University Of Thessaloniki | Phase 4 |
| Completed | A Dosing Study of Intravitreal Bevacizumab for Retinopathy of Prematurity NCT05712642 | Cairo University | Phase 3 |
| Completed | Pain Management During Screening for Retinopathy of Prematurity NCT04767178 | Istanbul Medeniyet University | — |
| Completed | Pain of Premature Babies and RetCam (DOLICAM) NCT04092127 | University Hospital, Grenoble | — |
| Completed | Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoag NCT04101721 | Regeneron Pharmaceuticals | Phase 3 |
| Completed | Stress Induced by Screening for Retinopathy of Prematurity - Should Speculum and Indentation Rather be Avoided NCT04408807 | Aristotle University Of Thessaloniki | N/A |
| Unknown | Zinc Supplementation on Very Low Birth Weight Infant NCT04050488 | Fakultas Kedokteran Universitas Indonesia | Phase 4 |
| Unknown | Fasudil Eye Drop in Retinopathy Of Prematurity(ROP) NCT04191954 | Shahid Beheshti University of Medical Sciences | Phase 2 / Phase 3 |
| Completed | Intravitreal Ranibizumab in Recurrent ROP NCT04539106 | Ameera Gamal Abdelhameed | — |
| Unknown | Analysis of Ocular and Neurodevelopmental Function for Retinopathy of Prematurity NCT05186155 | Chang Gung Memorial Hospital | — |
| Completed | Acupuncture for Preterm Infants Requiring Eye-exam NCT03650621 | University of Alberta | N/A |
| Completed | Long Term Outcome of Intravitreal Ranibizumab for ROP NCT04537065 | Ameera Gamal Abdelhameed | — |
| Withdrawn | Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age) NCT03399825 | Insel Gruppe AG, University Hospital Bern | — |
| Unknown | a Prospective Cohort Study for Propranolol Treatment in Retinopathy of Prematurity NCT03038295 | Guangdong Women and Children Hospital | Phase 2 |
| Completed | Analyzing Retinal Microanatomy in ROP NCT02887157 | Duke University | — |
| Unknown | Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants NCT02977000 | Huiqing Sun | N/A |
| Completed | Incidence, Risk Factors and Severity of Retinopathy of Prematurity (ROP) in Turkey NCT02814929 | Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital | — |
| Completed | The Effect of Eyemasks on Neonatal Stress Following Dilated Retinal Examination NCT03824782 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Enteral Administration of Docosahexaenoic Acid to Prevent Retinopathy of Prematurity NCT02683317 | Coordinación de Investigación en Salud, Mexico | N/A |
| Completed | Efficacy of Mydriatic Drops in Premature Infants NCT03448640 | Bulent Ecevit University | — |
| Withdrawn | Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population NCT02655432 | Université de Montréal | — |
| Completed | RAINBOW Study: RAnibizumab Compared With Laser Therapy for the Treatment of INfants BOrn Prematurely With Reti NCT02375971 | Novartis Pharmaceuticals | Phase 3 |
| Completed | Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Inf NCT03154723 | Huiqing Sun | N/A |
| Completed | Study of the Implication of Omega-3 Polyunsaturated Fatty Acids in Retinopathy of Prematurity in New-born Infa NCT02820662 | Centre Hospitalier Universitaire Dijon | N/A |
| Completed | Safety and Efficacy of Propranolol 0.2% Eye Drops in Treating Retinopathy of Premature: A Pilot Study (DROP-RO NCT02504944 | Meyer Children's Hospital IRCCS | Phase 2 |
| Completed | Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity NCT02390531 | Jaeb Center for Health Research | Phase 1 |
| Completed | Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) NCT02344225 | State University of New York - Downstate Medical Center | Phase 2 |
| Terminated | Telemedicine Approaches to Evaluating Acute-Phase ROP eROP Implementation Project NCT02257307 | Children's Hospital of Philadelphia | — |
| Completed | Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g NCT02102711 | Francesca Garofoli | N/A |
| Completed | Omega-3 Long Chain Polyunsaturated Fatty Acid (LCPUFA) Supplementation in Very Low Birth Weight Infants for Th NCT02486042 | University of California, San Diego | Phase 2 |
| Completed | Cost-effectiveness of Tele-expertise for Premature Infants for Retinopathy NCT02157727 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Infant-parent Skin-to-skin Contact During Screening for Retinopathy NCT02780544 | St. Olavs Hospital | N/A |
| Completed | REDEXAM - Reducing Painful Eye Examinations in Preterm Infants NCT01861470 | Newcastle-upon-Tyne Hospitals NHS Trust | — |
| Completed | Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature NCT02014454 | Meyer Children's Hospital IRCCS | Phase 2 |
| Unknown | Bevacizumab 0.500MG Intravitreal There Isn't Lower Than 0.625MG in the Treatment of ROP Type 1 NCT02090322 | Universidad Autonoma de San Luis Potosí | N/A |
| Completed | Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity NCT01780155 | National Institute of Environmental Health Sciences (NIEHS) | — |
| Completed | UK Surveillance of Treated Retinopathy of Prematurity NCT02484989 | Moorfields Eye Hospital NHS Foundation Trust | — |
| Completed | Effect of Vitamin E for Prevention of Retinopathy of Prematurity: A Randomized Clinical Trial. NCT03274596 | Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes | N/A |
| Completed | A Fatty Acids Study in Preventing Retinopathy of Prematurity NCT02760472 | Carola Pfeiffer-Mosesson | Phase 3 |
| Unknown | The Efficacy of Paracetamol in Reducing Pain During Ophthalmological Examination for Retinopathy of Prematurit NCT01872871 | Dr. Sami Ulus Children's Hospital | N/A |
| Completed | The Influence of Fish-oil Lipid Emulsions on Neonatal Morbidities NCT01875510 | Dr. Sami Ulus Children's Hospital | N/A |
| Completed | WINROP Algorithm Validation for Retinopathy Screening in a Cohort of Premature Infants NCT03347799 | Central Hospital, Nancy, France | — |
| Withdrawn | Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity (BLOCK-ROP) NCT01232777 | Vision Research Foundation | Phase 2 |
| Completed | Registry for Severe ROP and Treatment on Visual Outcomes NCT01559571 | Pediatrix | — |
| Completed | Changes in Vital Signs and Pupil Diameter Related to Pharmacologic Mydriasis in Premature Infants: A Randomize NCT04838665 | University of the Philippines | Phase 4 |
| Recruiting | Clinical and Genetic Analysis of ROP NCT04420156 | Oregon Health and Science University | — |
| Completed | Telemedicine Approaches to Evaluating Acute-phase ROP NCT01264276 | Children's Hospital of Philadelphia | — |
| Completed | Refractive Error and Biometry in Retinopathy of Prematurity NCT03334513 | San Ni Chen | — |
| Completed | Lucentis to Treat Retinopathy of Prematurity (ROP) 3 Plus Disease NCT02164604 | Kantonsspital Aarau | N/A |
| Terminated | Proparacaine and Mydriatic Eye Drops NCT01266824 | Children's Hospital of Philadelphia | N/A |
| Unknown | Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonat NCT02050971 | Pomeranian Medical University Szczecin | Phase 1 |
| Terminated | A Scan Ultrasonography in the Evaluation of Retinopathy of Prematurity NCT01335113 | Stanford University | — |
| Completed | Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective S NCT01238471 | Rambam Health Care Campus | Phase 1 / Phase 2 |
| Completed | Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2) NCT01030575 | NICHD Neonatal Research Network | Phase 2 |
| Completed | Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity NCT01079715 | Meyer Children's Hospital IRCCS | Phase 2 / Phase 3 |
| Completed | Skin and Serum Carotenoids in Preterm Infants Fed on a Formula Supplemented With Carotenoids NCT00872664 | University of Utah | N/A |
| Unknown | Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants NCT00910234 | China Medical University Hospital | Phase 1 / Phase 2 |
| Completed | Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening NCT00921544 | Coombe Women and Infants University Hospital | Phase 4 |
| Terminated | Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity NCT00702819 | Vision Research Foundation | Phase 1 |
| Completed | Pain Response During Examination for Retinopathy of Prematurity NCT00648687 | National Bioethics Commission of Brazil | N/A |
| Unknown | Bevacizumab Eliminates the Angiogenic Threat for Retinopathy of Prematurity NCT00622726 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term Infant NCT00623220 | Nabeel Ali | Phase 3 |
| Recruiting | Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome NCT00346814 | Asociación para Evitar la Ceguera en México | Phase 2 / Phase 3 |
| Withdrawn | VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and V NCT00563121 | Asociación para Evitar la Ceguera en México | Phase 4 |
| Terminated | Vascular Endothelial Growth Factor in Stage V ROP NCT00500396 | Asociación para Evitar la Ceguera en México | Phase 4 |
| Completed | Vitamin A and Very Low Birthweight Babies (VitAL) NCT00417404 | Glasgow Royal Infirmary | Phase 4 |
| Completed | Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants NCT00845624 | University of Virginia | — |
| Unknown | Cysteine Supplementation in Critically Ill Neonates NCT00254176 | University of California, Los Angeles | Phase 2 / Phase 3 |
| Completed | Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants NCT00349726 | NICHD Neonatal Research Network | Phase 2 |
| Unknown | Erythropoietin and Early Iron Supplement and Retinopathy of Prematurity NCT00339001 | Sheba Medical Center | — |
| Terminated | Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity NCT00634972 | University of South Alabama | Phase 4 |
| Terminated | Use of Sucrose to Relieve Pain During Eye Exams in Infants NCT00161694 | Weill Medical College of Cornell University | N/A |
| Completed | Appropriate Oxygen Levels for Extremely Preterm Infants: a Prospective Meta-analysis NCT01124331 | University of Sydney | N/A |
| Completed | Surfactant Positive Airway Pressure and Pulse Oximetry Trial NCT00233324 | NICHD Neonatal Research Network | Phase 3 |
| Completed | Ultrasound to Detect Evidence for Retinal Detachment in Retinopathy of Prematurity NCT00279669 | Weill Medical College of Cornell University | — |
| Completed | Pain in Neonates During Screening for Retinopathy of Prematurity Using Two Methods NCT00895869 | NHS Lothian | — |
| Unknown | The Early Treatment for Retinopathy of Prematurity Study (ETROP) NCT00027222 | National Eye Institute (NEI) | Phase 2 / Phase 3 |
| Completed | Retinopathy of Prematurity:Summary of a Decade NCT01363960 | Saglik Bilimleri Universitesi Gulhane Tip Fakultesi | — |
| Completed | Heredity of Retinal Vessel Tortuosity NCT00427063 | Glostrup University Hospital, Copenhagen | — |
| Completed | The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP) NCT00000156 | National Eye Institute (NEI) | Phase 3 |
| Completed | Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity NCT01203436 | NICHD Neonatal Research Network | Phase 2 / Phase 3 |
| Completed | Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Premat NCT00000133 | National Eye Institute (NEI) | N/A |
| No Longer Available | Use of Pan-vascular Endothelial Growth Factor Receptor (Pan-VEGF) Blockade for the Treatment of Retinopathy of NCT00870636 | Children's Hospital Los Angeles | — |