| Not Yet Recruiting | Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration NCT07425717 | Shanghai High Myopia Study Group | N/A |
| Not Yet Recruiting | First-in-Human, Dose Escalation Trial of AXV-101 in BBS1-Related Retinal Degeneration NCT07269665 | Axovia Therapeutics | EARLY_Phase 1 |
| Recruiting | SGLT2 Inhibitors in Geographic Atrophy NCT07174687 | Washington University School of Medicine | Phase 2 |
| Recruiting | A Repeat-Dose, Open-Label, Two Arm Safety and Efficacy Study of Two Doses of VP-001 Administered Intravitreall NCT06852963 | PYC Therapeutics | Phase 1 / Phase 2 |
| Recruiting | A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO) NCT06789445 | BlueRock Therapeutics | Phase 1 / Phase 2 |
| Completed | MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby) NCT06455826 | PYC Therapeutics | Phase 1 |
| Recruiting | A Efficacy and Safety Study of Ranibizumab 10mg/ml Injection (Incepta) in Patients With Diabetic Macular Edema NCT06305416 | Incepta Pharmaceuticals Ltd | Phase 3 |
| Active Not Recruiting | Safety and Efficacy Study of IVB102 Injection in Subjects With X-linked Retinoschisis NCT06289452 | InnoVec Biotherapeutics Inc. | EARLY_Phase 1 |
| Unknown | Validation of Questionnaire in Retinal Degeneration NCT06185517 | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | N/A |
| Active Not Recruiting | Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study NCT06162585 | Nanoscope Therapeutics Inc. | — |
| Completed | Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DM NCT06011798 | Unity Biotechnology, Inc. | Phase 2 |
| Enrolling By Invitation | A Long-Term Follow-Up Study in Subjects Who Received vMCO-I Administered Via Intravitreal Injection NCT05921162 | Nanoscope Therapeutics Inc. | — |
| Enrolling By Invitation | Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab NCT06167642 | Johns Hopkins University | — |
| Active Not Recruiting | Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study NCT05797896 | Complement Therapeutics | — |
| Unknown | Pistachios and Neural Macular Pigment NCT05283941 | Tufts University | N/A |
| Recruiting | Minocycline for Chronic Autoimmune Uveitis NCT05474729 | Sun Yat-sen University | Phase 1 / Phase 2 |
| Recruiting | Adaptive Optics Imaging of Outer Retinal Diseases NCT05355415 | Food and Drug Administration (FDA) | — |
| Completed | Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE] NCT04945772 | Nanoscope Therapeutics Inc. | Phase 2 |
| Active Not Recruiting | Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F NCT04765345 | Jaeb Center for Health Research | — |
| Unknown | An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerabil NCT04855045 | ProQR Therapeutics | Phase 2 / Phase 3 |
| Terminated | A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Neovascular Age-related Macular Degenerat NCT04684394 | Gemini Therapeutics, Inc. | Phase 2 |
| Recruiting | Oral Metformin for Treatment of ABCA4 Retinopathy NCT04545736 | National Eye Institute (NEI) | Phase 1 / Phase 2 |
| Terminated | A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular Degeneration NCT04643886 | Gemini Therapeutics, Inc. | Phase 2 |
| Terminated | NR600 System Retinal Prosthesis for Patients With Retinal Degenerative Diseases NCT04295304 | Nano Retina | N/A |
| Completed | First in Human Study to Evaluate the Safety and Tolerability of GEM103 in Geographic Atrophy Secondary to Dry NCT04246866 | Gemini Therapeutics, Inc. | Phase 1 |
| Completed | Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravitreal vMCO-I in Patients With Advanced NCT04919473 | Nanoscope Therapeutics Inc. | Phase 1 / Phase 2 |
| Unknown | Bimodal and Coaxial High Resolution Ophtalmic Imaging NCT04620876 | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | N/A |
| Unknown | Single Ascending Dose Study in Participants With LCA10 NCT03872479 | Editas Medicine, Inc. | Phase 1 / Phase 2 |
| Recruiting | High Resolution, High-speed Multimodal Ophthalmic Imaging NCT04129021 | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | N/A |
| Completed | Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD NCT03954626 | Novartis Pharmaceuticals | Phase 3 |
| Completed | Dual Wavelength OCT NCT03843840 | Moorfields Eye Hospital NHS Foundation Trust | — |
| Unknown | Assessment of Visual Function With a Portable Brain-computer Interface NCT03760055 | NGoggle | — |
| Terminated | GTSCOPE - To Evaluate the Natural Progression of Dry Age-related Macular Degeneration (AMD) NCT03894020 | Gyroscope Therapeutics Limited | — |
| Terminated | FOCUS: A Phase I/II First in Human Study to Evaluate the Safety and Efficacy of GT005 Administered in Subjects NCT03846193 | Gyroscope Therapeutics Limited | Phase 1 / Phase 2 |
| Unknown | Stem Cells Therapy in Degenerative Diseases of the Retina NCT03772938 | Pomeranian Medical University Szczecin | Phase 1 |
| Completed | BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases NCT03318549 | University of Miami | N/A |
| Completed | Performance of Long-wavelength Autofluorescence Imaging NCT03592017 | Oxford University Hospitals NHS Trust | N/A |
| Terminated | Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS NCT03561922 | Retina Implant AG | N/A |
| Unknown | The Effects of Cannabis on Visual Functions in Healthy and Retinitis Pigmentosa Patients NCT03078309 | Hadassah Medical Organization | EARLY_Phase 1 |
| Unknown | High Resolution Retina Imaging NCT04128150 | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | — |
| Completed | Evaluation of Discomfort Associated With Scleral Depression During Retina Examinations NCT04115917 | New York City Health and Hospitals Corporation | N/A |
| Completed | Natural History Study of CEP290-Related Retinal Degeneration NCT03396042 | Editas Medicine, Inc. | — |
| Completed | Quality of Life Measures in Patients With Retinal Degeneration NCT02814435 | University of Oxford | — |
| Recruiting | Rod and Cone Mediated Function in Retinal Disease NCT02617966 | National Eye Institute (NEI) | — |
| Completed | Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacificatio NCT03321253 | Afyon Kocatepe University Hospital | N/A |
| Completed | The Effect of Laser Treatment on Macular Pigment of Eye in Cases With Diabetes NCT03150654 | Afyon Kocatepe University Hospital | N/A |
| Completed | Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of OPT-302 With or Without Lucentis™ in Pat NCT02543229 | Opthea Limited | Phase 1 |
| Terminated | X-82 to Treat Age-related Macular Degeneration NCT02348359 | Tyrogenex | Phase 2 |
| Unknown | Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Glaucomatous Neurodegeneration NCT02144103 | Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation | Phase 1 / Phase 2 |
| Completed | Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma. NCT02330978 | University of Sao Paulo | Phase 1 |
| Completed | Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration NCT02157077 | Centre Hospitalier Intercommunal Creteil | Phase 3 |
| Active Not Recruiting | Natural History of Eye Diseases Related to ABCA4 Mutations NCT01736293 | National Eye Institute (NEI) | — |
| Completed | Safety and Efficacy Study of rAAV.sFlt-1 in Patients With Exudative Age-Related Macular Degeneration NCT01494805 | Lions Eye Institute, Perth, Western Australia | Phase 1 / Phase 2 |
| Completed | Safety & Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients NCT01497379 | Retina Implant AG | N/A |
| Recruiting | Cell Collection to Study Eye Diseases NCT01432847 | National Eye Institute (NEI) | — |
| Completed | Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa NCT01399515 | Seoul National University Hospital | Phase 2 |
| Unknown | Saffron Supplementation in Stargardt's Disease NCT01278277 | Catholic University of the Sacred Heart | Phase 1 / Phase 2 |
| Completed | Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Includin NCT01003691 | Pfizer | Phase 1 |
| Completed | Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AM NCT01024998 | Genzyme, a Sanofi Company | Phase 1 |
| Completed | Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients NCT01024803 | Retina Implant AG | N/A |
| Completed | Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration NCT00877032 | Pfizer | Phase 1 |
| Completed | A Multi-Center Study of Reading Rehabilitation in Macular Disease NCT00746668 | US Department of Veterans Affairs | N/A |
| Completed | Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis NCT00643747 | University College, London | Phase 1 / Phase 2 |
| Completed | Clinical and Pathophysiological Description of Ocular Ischemic Syndrome NCT00403195 | Glostrup University Hospital, Copenhagen | — |
| Completed | Molecular Genetics of Retinal Degenerations NCT00231010 | National Eye Institute (NEI) | — |
| Completed | Measuring Reading Rehabilitation Outcomes NCT00125632 | US Department of Veterans Affairs | N/A |
| Completed | Studies of Patients With Skin Disease, Patients With Neurological Degenerations, and Normal Volunteers NCT00001164 | National Cancer Institute (NCI) | — |