NCT07425717

Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration

Effectiveness of TMS for Visual Restoration: a Multicenter Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 136 (estimated)
• Sponsor: Shanghai High Myopia Study Group · Academic / Other
• Sex: All
• Age: 45 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment. The main questions it aims to answer are: 1. Does TMS treatment improve the visual function of participants? 2. What medical problems do participants have when receiving TMS treatment? Researchers will compare TMS treatment to a sham stimulation (identical procedures using a sham coil without effective magnetic field output) to see if TMS treatment works to restore their vision. Participants will: UndergoTMS treatment to a sham stimulation for consecutive 5 days Visit the clinic at 5 days, 4 weeks, 3 months, 6 months, 12 months after start of the treatment for checkups and tests

Conditions

• Retinal Degeneration
• Vision Impairment and Blindness

Interventions

Type	Name	Description
PROCEDURE	Transcranial magnetic stimulation targeting occipital visual cortex	Transcranial magnetic stimulation targeting occipital visual cortex
PROCEDURE	Sham stimulation	identical procedure using a sham coil without effective magnetic field output

Timeline

• Start date: 2026-06-01
• Primary completion: 2028-05-31
• Completion: 2029-05-31
• First posted: 2026-02-23
• Last updated: 2026-02-23

Locations

4 sites across 1 country: China