| Not Yet Recruiting | Antibiotic-coated Braided Suture Study NCT07322289 | University of Miami | N/A |
| Not Yet Recruiting | Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections NCT07426471 | IRCCS San Raffaele | — |
| Not Yet Recruiting | Study of the Lived Experience of Patients With Prosthetic Joint Infection, Their Families, and Healthcare Prof NCT07409402 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Reduction of Bacterial Seeding in Total Shoulder Arthroplasty NCT07406893 | St. Louis University | N/A |
| Recruiting | Methylene Blue in Total Knee Arthroplasty (TKA) NCT07324954 | University of Miami | Phase 1 |
| Recruiting | Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, an NCT07214311 | Peptilogics | Phase 2 / Phase 3 |
| Withdrawn | Knee Prosthetic Joint Infection Antibiotic Elution NCT06023238 | University of Pittsburgh | — |
| Not Yet Recruiting | PCA Administration in Prosthetic Joint Infection NCT06591741 | Dr. Dean Reeves Clinic | N/A |
| Recruiting | Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care. NCT07107685 | Assistance Publique - Hôpitaux de Paris | — |
| Enrolling By Invitation | Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee NCT06636669 | Boston Medical Center | Phase 4 |
| Recruiting | The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infec NCT06919913 | NYU Langone Health | N/A |
| Recruiting | OsteoArticular Sepsis in Intensive Care unitS NCT06627842 | Assistance Publique - Hôpitaux de Paris | — |
| Enrolling By Invitation | New Molecular Approaches for Diagnosis of Prosthetic Joint Infection NCT06670885 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Recruiting | Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection NCT06293352 | Northwestern University | N/A |
| Not Yet Recruiting | Incidence of Early Infection After Bipolar Hemiarthroplasty and Its Associated Factors in Fracture Neck of Fem NCT06427772 | Assiut University | — |
| Withdrawn | Benzoyl Peroxide and Electrocautery Skin Incision to Eradicate Cutibacterium Acnes NCT05676411 | University of Missouri-Columbia | Phase 4 |
| Recruiting | Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections NCT06062251 | University Hospital, Brest | — |
| Unknown | LE as a Marker for Periprosthetic Joint Infection NCT05440032 | Center for Innovation and Research Organization | — |
| Completed | SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty NCT05919888 | St. Louis University | Phase 4 |
| Recruiting | Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection NCT06172010 | Leiden University Medical Center | Phase 4 |
| Withdrawn | Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI) NCT05269134 | Adaptive Phage Therapeutics, Inc. | Phase 2 |
| Unknown | Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III) NCT05676801 | University of Zurich | EARLY_Phase 1 |
| Recruiting | SHort Interval Full Two-stage Implant Exchange NCT05642013 | University Hospital, Montpellier | N/A |
| Completed | A Second Trial of the Abbreviated Protocol Two-Stage Exchange NCT05607030 | Osteal Therapeutics, Inc. | Phase 2 |
| Unknown | Physiopathology of Prosthetic Joint Infections NCT05551572 | Assistance Publique - Hôpitaux de Paris | — |
| Withdrawn | Bacteriophage Therapy in Patients With Prosthetic Joint Infections NCT04787250 | Adaptive Phage Therapeutics, Inc. | Phase 1 / Phase 2 |
| Unknown | NGS vs Culture Outcomes for Treatment of PJI NCT05247281 | Center for Innovation and Research Organization | N/A |
| Unknown | Surgiphor vs Saline Joints NCT05434260 | Center for Innovation and Research Organization | N/A |
| Active Not Recruiting | Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fra NCT05530174 | Soren Overgaard | N/A |
| Active Not Recruiting | Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA NCT05530551 | Soren Overgaard | N/A |
| Withdrawn | Bacteriophage Therapy in First Time Chronic Prosthetic Joint Infections NCT05269121 | Adaptive Phage Therapeutics, Inc. | Phase 1 / Phase 2 |
| Recruiting | Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals Leu NCT05000723 | Universitaire Ziekenhuizen KU Leuven | — |
| Recruiting | Phage Safety Cohort Study NCT04650607 | Hospices Civils de Lyon | — |
| Recruiting | Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement. NCT05169229 | University Hospital, Linkoeping | Phase 2 / Phase 3 |
| Unknown | Antibiogram and Biofilm Formation of Bacteria Causing Prosthetic Joint Infections Isolated From Assiut Univers NCT05239312 | Assiut University | — |
| Unknown | 68Ga-citrate PET/CT for the Diagnosis of Chronic Prosthetic Hip or Knee Infection NCT04938193 | University Hospital, Bordeaux | Phase 2 |
| Recruiting | Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Mar NCT04858217 | Istituto Ortopedico Rizzoli | — |
| Completed | Abbreviated Protocol for Two-Stage Exchange NCT04662632 | Osteal Therapeutics, Inc. | Phase 2 |
| Unknown | Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections NCT04488458 | Vastra Gotaland Region | N/A |
| Completed | Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic) NCT05265598 | University Hospital, Basel, Switzerland | — |
| Unknown | Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection NCT04746001 | Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust | — |
| Unknown | Clindamycin in Prosthetic Joint Infections Caused by Staphylococcus (CISTA) NCT04946500 | University Hospital, Brest | — |
| Completed | Measuring Distress in Prosthetic Joint Infection Using a Standardized Metric: CRUTCH Pathway Pilot. NCT04762706 | West Virginia University | N/A |
| Completed | Tissue Distribution, Pharmacokinetics, Safety, and Tolerability After a Single Dose of TNP-2092 in Participant NCT04294862 | TenNor Therapeutics Limited | Phase 1 |
| Completed | Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint Infections NCT04763759 | Trellis Bioscience LLC | Phase 1 |
| Recruiting | Phage Safety Retrospective Cohort Study NCT04724603 | Hospices Civils de Lyon | — |
| Completed | Staphylococcus Lugdunensis Prosthetic Joint Infection NCT04409392 | Hospices Civils de Lyon | — |
| Completed | Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II) NCT04618276 | University of Zurich | N/A |
| Unknown | Leukocyte Esterase Sensor Test NCT04390607 | Rothman Institute Orthopaedics | — |
| Unknown | Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint I NCT04661345 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Unknown | Percutaneous Punch Biopsy for Diagnosis of Septic and Aseptic Prosthetic Joint Failure NCT04620395 | Vivantes Netzwerk für Gesundheit GmbH | N/A |
| Unknown | Integrated Microfluidic Systems for Diagnosis of Periprosthetic Joint Infection NCT04056780 | Chang Gung Memorial Hospital | — |
| Completed | Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol NCT04042233 | The Methodist Hospital Research Institute | Phase 4 |
| Completed | Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study NCT04067843 | University of Zurich | N/A |
| Unknown | ARTHR-IS (Arthroplasties' Infections Due to Staphylococcus Aureus) NCT03826108 | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | — |
| Unknown | Calprotectin in Chronic Prosthetic Joint Infection NCT05060952 | Technical University of Munich | — |
| Completed | Short or Long Antibiotic Regimes in Orthopaedics NCT03806166 | Oxford University Hospitals NHS Trust | N/A |
| Unknown | Alpha Defensin and 16S rRNA Gene in Diagnosis of PJI NCT03714165 | Assiut University | — |
| Unknown | New Strategies for Biofilm Related Infections NCT03784807 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Completed | Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty NCT03694925 | The Cleveland Clinic | — |
| Completed | Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation NCT03721328 | Osteal Therapeutics, Inc. | Phase 2 |
| Completed | Tedizolid Prolonged Treatment for Prosthetic Joint Infections NCT03378427 | Tourcoing Hospital | N/A |
| Completed | Arthroplasty and Modifiable Risk Factors NCT05399186 | Landspitali University Hospital | N/A |
| Completed | Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections NCT03426761 | Infectious Diseases Physicians, Inc. | Phase 4 |
| Unknown | Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection NCT05211011 | Charite University, Berlin, Germany | Phase 4 |
| Unknown | Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection NCT03260010 | Pro-Implant Foundation | Phase 4 |
| Recruiting | Quality of Life in Patients Having a Prosthetic Joint Infection NCT03307109 | Hospices Civils de Lyon | — |
| Completed | Metal Artifact Reduction Sequence MRI for Surgical Decision-Making in Infected Unicompartmental Knee Arthropla NCT07208968 | First Affiliated Hospital of Fujian Medical University | — |
| Unknown | The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection NCT03200470 | Rothman Institute Orthopaedics | — |
| Completed | Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint In NCT03612076 | Hospices Civils de Lyon | — |
| Completed | Rapid Diagnosis of Prosthetic Joint Infection by Matrix-assisted Laser Desorption NCT03717090 | Chang Gung Memorial Hospital | — |
| Unknown | Quality of Life Assessment in Patients Undergoing Prolonged Suppressive Antibiotherapy for Prosthetic Joint In NCT02805803 | Groupe Hospitalier Diaconesses Croix Saint-Simon | N/A |
| Completed | Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection NCT02806063 | Groupe Hospitalier Diaconesses Croix Saint-Simon | N/A |
| Completed | One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections NCT03473392 | Hospices Civils de Lyon | — |
| Completed | Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in At-risk Patients NCT03848091 | Hospices Civils de Lyon | — |
| Recruiting | Cohort of Prosthetic Joint Infections NCT02801253 | Groupe Hospitalier Diaconesses Croix Saint-Simon | — |
| Unknown | Evaluation of the Antibiofilmogramme Test During Orthopaedic Device-Related Infection NCT03263832 | BioFilm Control | — |
| Completed | The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures NCT02413034 | Parc de Salut Mar | N/A |
| Completed | Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection NCT01373112 | Rush University Medical Center | N/A |
| Completed | Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement NCT01373099 | Rush University Medical Center | N/A |
| Completed | Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement NCT00829556 | Rothman Institute Orthopaedics | N/A |
| Temporarily Not Available | Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty NCT06383611 | Osteal Therapeutics, Inc. | — |