NCT05247281

NGS vs Culture Outcomes for Treatment of PJI

Randomized Controlled Trial Investigating the Use of Next-generation Sequencing in Directing the Antimicrobial Treatment of Periprosthetic Joint Infection

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Center for Innovation and Research Organization · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.

Conditions

• Prosthetic Joint Infection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Culture-based treatment	Medications to treat prosthetic joint infection will be chosen based on results of traditional cultures alone
DIAGNOSTIC_TEST	Next Generation Sequencing (NGS) with Culture	Medications to treat prosthetic joint infection will be chosen based results of NGS and culture

Timeline

• Start date: 2022-09-21
• Primary completion: 2024-05-01
• Completion: 2025-05-01
• First posted: 2022-02-18
• Last updated: 2023-11-08

Locations

9 sites across 1 country: United States