NCT05265598

Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic)

Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 176 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.

Detailed description

Implant associated infections in orthopaedics and trauma surgery are a well-known and feared complication. Prosthetic-joint infection (PJI) is caused by a biofilm which is located atop the surface of the implant which as growing with the duration of the PJI. This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.

Conditions

• Prosthetic-joint Infection

Timeline

• Start date: 2021-06-30
• Primary completion: 2023-03-11
• Completion: 2024-08-31
• First posted: 2022-03-03
• Last updated: 2025-01-22

Locations

1 site across 1 country: Switzerland