NCT03848091

Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in At-risk Patients

Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: —

Summary

One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic. This strategy is not recommended in patients infected with multidrug-resistant organisms or difficult to treat because of a risk of bacterial persistence on the new implant. Antibiotic pretreatment by a narrow-spectrum molecule and for which resistance acquisition is difficult might be of interest to try to reduce the inoculum and avoid contamination of the new implant.

Conditions

• Prosthetic Joint Infection
• Antibiotic Resistant Infection

Interventions

Type	Name	Description
OTHER	Antibiotic pretreatment	a strategy with antibiotic pretreatment before one-step exchange arthroplasty in patients who bacteria responsible for the infection has been indentified (puncture, blood cultures,...)

Timeline

• Start date: 2016-04-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2019-02-20
• Last updated: 2024-02-28

Locations

1 site across 1 country: France