Clinical Trials Directory

Trials / Conditions / Primary Myelofibrosis

Primary Myelofibrosis

138 registered clinical trials studyying Primary Myelofibrosis25 currently recruiting.

StatusTrialSponsorPhase
RecruitingRegistry Platform Myelofibrosis and Anemia
NCT06976918
iOMEDICO AG
RecruitingRuxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and My
NCT07228624
Fred Hutchinson Cancer CenterPhase 2
RecruitingA Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)
NCT06661915
National Cancer Institute (NCI)Phase 2
RecruitingP1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk
NCT06468033
PharmaEssentiaPhase 3
RecruitingUAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy
NCT06047886
University of Alabama at BirminghamPhase 1
RecruitingStudy of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis
NCT06517875
GlaxoSmithKlinePhase 2
RecruitingA Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosi
NCT06343805
Ajax Therapeutics, Inc.Phase 1
RecruitingOpen Label Phase 1/2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera
NCT06327100
M.D. Anderson Cancer CenterPhase 1 / Phase 2
RecruitingStudy of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Subop
NCT06479135
Kartos Therapeutics, Inc.Phase 3
RecruitingFunctional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes
NCT06361641
University Hospital, AngersN/A
RecruitingA Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)
NCT06351631
Merck Sharp & Dohme LLCPhase 3
RecruitingPacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition
NCT06218628
Fox Chase Cancer CenterPhase 1
UnknownReal World Evidence of Fedratinib Effectiveness in MF
NCT05883904
Gruppo Italiano Malattie EMatologiche dell'Adulto
RecruitingRole of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cel
NCT06896344
Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting68Ga-FAPI PET/CT Imaging for Diagnosis, Grading, and Efficacy Evaluation of Myelofibrosis.
NCT06151119
The First Affiliated Hospital of Xiamen University
RecruitingA Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis
NCT06073847
Bristol-Myers Squibb
RecruitingAsian Myeloproliferative Neoplasm (MPN) Registry
NCT05882773
The University of Hong Kong
TerminatedStudy to Assess Efficacy and Safety of NS-018 Compared to BAT in Patients With Myelofibrosis
NCT04854096
NS Pharma, Inc.Phase 2
Active Not RecruitingAdding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patien
NCT05364762
City of Hope Medical CenterPhase 2
RecruitingStudy of Canakinumab in Patients With Myelofibrosis
NCT05467800
John MascarenhasPhase 2
CompletedFedratinib in Combination With Nivolumab
NCT05393674
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus NordwestPhase 2
RecruitingStudy of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a
NCT05280509
Telios Pharma, Inc.Phase 1 / Phase 2
RecruitingStudy of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
NCT05320198
Disc Medicine, IncPhase 1 / Phase 2
RecruitingRuxolitinib in Primary Myelofibrosis and Secondary to Essential Thrombocythemia or Polycythemia Vera
NCT06516406
IRCCS Azienda Ospedaliero-Universitaria di Bologna
CompletedAn Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-72
NCT05223920
Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)Phase 2
TerminatedTo Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Sub
NCT04551053
Incyte CorporationPhase 3
TerminatedTo Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-
NCT04551066
Incyte CorporationPhase 3
Active Not RecruitingPhase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
NCT04603495
Novartis PharmaceuticalsPhase 3
WithdrawnA Study of LNK01002 in Patients With Primary or Secondary Myelofibrosis,Polycythemia Vera or Acute Myeloid Leu
NCT04896112
Lynk Pharmaceuticals Co., LtdPhase 1
Active Not RecruitingAn Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neop
NCT04717414
CelgenePhase 3
CompletedAssessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patient
NCT04243122
Ottawa Hospital Research InstitutePhase 2
Active Not RecruitingElotuzumab for the Treatment of JAK2-Mutated Myelofibrosis
NCT04517851
M.D. Anderson Cancer CenterPhase 2
RecruitingReduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis
NCT04370301
Fred Hutchinson Cancer CenterPhase 2
Active Not RecruitingPeritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis
NCT04384692
Fred Hutchinson Cancer CenterPhase 2
WithdrawnStudy of Select Combinations in Adults With Myelofibrosis
NCT04283526
Novartis PharmaceuticalsPhase 1
UnknownKRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intoleran
NCT04640532
Kartos Therapeutics, Inc.Phase 1 / Phase 2
CompletedItacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplas
NCT04339101
City of Hope Medical CenterPhase 2
Active Not RecruitingA Study of Fedratinib in Japanese Subjects With DIPSS (Dynamic International Prognostic Scoring System)- Inter
NCT04446650
Bristol-Myers SquibbPhase 1 / Phase 2
TerminatedSerial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
NCT03878524
OHSU Knight Cancer InstitutePhase 1
RecruitingDecitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloprolif
NCT04282187
University of WashingtonPhase 2
CompletedA Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)
NCT04173494
Sierra Oncology LLC - a GSK companyPhase 3
CompletedAn Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermedi
NCT03952039
CelgenePhase 3
WithdrawnPAT-1251 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essent
NCT04054245
M.D. Anderson Cancer CenterPhase 2
TerminatedSelinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors
NCT03627403
University of UtahPhase 2
TerminatedA Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythem
NCT03755518
CelgenePhase 3
CompletedMPN-RC 118 AVID200 in Myelofibrosis
NCT03895112
John MascarenhasPhase 1
TerminatedEvaluation of Ruxolitinib in Combination With PU-H71 for Treatment of Myelofibrosis
NCT03373877
Samus Therapeutics, Inc.Phase 1
TerminatedAllogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis
NCT03303950
University of UtahPhase 2
CompletedCombination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients Wi
NCT03426969
M.D. Anderson Cancer CenterEARLY_Phase 1
CompletedA Safety and Efficacy Study to Evaluate Luspatercept in Subjects With Myeloproliferative Neoplasm-associated M
NCT03194542
CelgenePhase 2
CompletedPhase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary My
NCT04884191
CTI BioPharmaPhase 2
RecruitingA Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or
NCT03165734
Swedish Orphan BiovitrumPhase 3
CompletedPD-1 Inhibition in Advanced Myeloproliferative Neoplasms
NCT03065400
John MascarenhasPhase 2
TerminatedManagement of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced Thrombocytopenia
NCT03195010
Fred Hutchinson Cancer CenterPhase 2
CompletedUltrasound Examination for Spleen Volume Evaluation in Myeloproliferative Neoplasms
NCT06371573
Federico II University
CompletedEfficacy and Safety of Ruxolitinib in the Treatment of Anemic Myelofibrosis Patients.
NCT02966353
Novartis PharmaceuticalsPhase 2
CompletedCalcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT
NCT03018223
H. Lee Moffitt Cancer Center and Research InstitutePhase 1
CompletedRuxolitinib Phosphate and Chemotherapy Given Before and After Reduced Intensity Donor Stem Cell Transplant in
NCT02917096
City of Hope Medical CenterPhase 1
WithdrawnDurvalumab in Treating Patients With Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelof
NCT02871323
Northwestern UniversityPhase 1
WithdrawnSiltuximab in Treating Patients With Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelof
NCT02805868
Northwestern UniversityEARLY_Phase 1
TerminatedSirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HS
NCT02728700
Stanford UniversityPhase 1
CompletedPTCy and Ruxolitinib GVHD Prophylaxis in Myelofibrosis
NCT02806375
St. Petersburg State Pavlov Medical UniversityPhase 1 / Phase 2
WithdrawnA Phase II Non-Controlled, Open-Label, Efficacy, Safety, Pharmacokinetic, and Pharmacodynamic Study of Pacriti
NCT02584777
Baxalta now part of ShirePhase 2
WithdrawnRuxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced I
NCT02528877
City of Hope Medical CenterPhase 1
UnknownAlisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia
NCT02530619
Northwestern UniversityN/A
RecruitingMyeloproliferative Neoplastic Diseases Observatory From Brest
NCT02897297
University Hospital, Brest
TerminatedP1101 in Treating Patients With Myelofibrosis
NCT02370329
Mayo ClinicPhase 2
TerminatedNivolumab in Treating Patients With Primary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, or Po
NCT02421354
M.D. Anderson Cancer CenterPhase 2
RecruitingMyeloproliferative Neoplasms (MPNs) Patient Registry
NCT02760238
University Health Network, Toronto
CompletedSympathicomimetic Agonist in Patients With Myeloproliferative Neoplasms With JAK2-mutation
NCT02311569
Swiss Cancer InstitutePhase 2
Active Not RecruitingCINC424A2X01B Rollover Protocol
NCT02386800
Novartis PharmaceuticalsPhase 4
CompletedLCL161 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essentia
NCT02098161
M.D. Anderson Cancer CenterPhase 2
CompletedJAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis
NCT02251821
Fred Hutchinson Cancer CenterPhase 2
TerminatedA Phase II Study of Re-treatment of Myelofibrosis Patients With Ruxolitinib/Jakavi After Treatment Interruptio
NCT02091752
Novartis PharmaceuticalsPhase 2
CompletedA Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative
NCT02158858
Constellation PharmaceuticalsPhase 1 / Phase 2
CompletedAzacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies
NCT02129101
Mayo ClinicPhase 1
CompletedLong-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera My
NCT02124746
Sierra Oncology LLC - a GSK companyPhase 2
TerminatedPacritinib Versus Best Available Therapy to Treat Patients With Myelofibrosis and Thrombocytopenia
NCT02055781
CTI BioPharmaPhase 3
TerminatedConnect® Myeloid Disease Registry
NCT01688011
Celgene
CompletedMomelotinib Versus Ruxolitinib in Subjects With Myelofibrosis
NCT01969838
Sierra Oncology LLC - a GSK companyPhase 3
TerminatedRuxolitinib Prior to Transplant in Patients With Myelofibrosis
NCT01790295
John MascarenhasPhase 2
CompletedA Phase 2 Study of RO7490677 In Participants With Myelofibrosis
NCT01981850
Hoffmann-La RochePhase 2
CompletedRuxolitinib and Pomalidomide Combination Therapy in Patients With Primary and Secondary MF
NCT01644110
University of UlmPhase 1 / Phase 2
CompletedA Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF
NCT01787552
Novartis PharmaceuticalsPhase 1 / Phase 2
CompletedMyeloproliferative Neoplasms: an In-depth Case-control Study
NCT01831635
Queen's University, Belfast
CompletedRuxolitinib Phosphate and Danazol in Treating Anemia in Patients With Myelofibrosis
NCT01732445
Mayo ClinicPhase 2
CompletedRuxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myel
NCT01787487
M.D. Anderson Cancer CenterPhase 2
TerminatedPacritinib Versus Best Available Therapy to Treat Myelofibrosis
NCT01773187
CTI BioPharmaPhase 3
CompletedImetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis
NCT01731951
Geron CorporationPhase 2
CompletedVaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing
NCT01588015
City of Hope Medical CenterPhase 1
CompletedA Prospective, Two-arm, Non-interventional Study of JAKAVI® (Ruxolitinib) in Patients With Myelofibrosis
NCT05044026
Novartis Pharmaceuticals
WithdrawnMechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant
NCT01558778
Roswell Park Cancer InstituteN/A
UnknownMyeloproliferative Neoplasms and Bone Structure
NCT01816022
University of Southern Denmark
CompletedFludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem
NCT01529827
Roswell Park Cancer InstitutePhase 2
CompletedEltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Re
NCT01428635
M.D. Anderson Cancer CenterPhase 2 / Phase 3
CompletedA Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasms
NCT01387763
Thomas Stauffer LarsenPhase 3
CompletedA Phase 2 Study With IPI-926 in Patients With Myelofibrosis
NCT01371617
Infinity Pharmaceuticals, Inc.Phase 2
CompletedAlternative Dosing Strategy of Ruxolitinib in Patients With Myelofibrosis
NCT01445769
Incyte CorporationPhase 2
CompletedA Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies
NCT01384513
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityPhase 2
CompletedSafety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemi
NCT01423058
Sierra Oncology LLC - a GSK companyPhase 1 / Phase 2
CompletedSafety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Ve
NCT01423851
NS Pharma, Inc.Phase 1 / Phase 2
UnknownAssessment of Labile Plasma Iron (LPI) in Myelodysplastic Syndromes (MDS) and Primary Myelofibrosis
NCT01331603
Wolfson Medical Center
TerminatedAnti-TGF-beta Therapy in Patients With Myelofibrosis
NCT01291784
John MascarenhasPhase 1
CompletedProlonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia
NCT01484015
Wake Forest University Health SciencesPhase 1
CompletedDeferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies
NCT01273766
Wake Forest University Health SciencesPhase 2
Active Not RecruitingInfection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic
NCT01199562
City of Hope Medical Center
CompletedExtension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or
NCT01236638
Sierra Oncology LLC - a GSK companyPhase 2
CompletedStudy of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion
NCT01178281
CelgenePhase 3
CompletedPalifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Tran
NCT01233921
Martin, PaulN/A
TerminatedDeferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload
NCT01159067
City of Hope Medical CenterPhase 2
CompletedA Study in Myeloproliferative Disorders
NCT01134120
Eli Lilly and CompanyPhase 1
TerminatedArsenic Trioxide With or Without Ascorbic Acid in Treating Patients With Myelofibrosis
NCT01014546
Roswell Park Cancer InstitutePhase 1
CompletedMassage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Canc
NCT01053494
Wake Forest University Health SciencesN/A
CompletedSafety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-esse
NCT00935987
Sierra Oncology LLC - a GSK companyPhase 1 / Phase 2
UnknownLBH589 (Panobinostat) for the Treatment of Myelofibrosis
NCT01298934
Ronald HoffmanPhase 1 / Phase 2
TerminatedA Study to Evaluate Safety and Efficacy of Panobinostat in Participants With Primary Myelofibrosis
NCT00931762
Novartis PharmaceuticalsPhase 2
CompletedSunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy
NCT00890747
National Cancer Institute (NCI)Phase 1
CompletedFludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With
NCT00856388
Roswell Park Cancer InstituteN/A
CompletedOndansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant
NCT00795769
Fred Hutchinson Cancer CenterPhase 2
CompletedInternet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors
NCT00799461
Fred Hutchinson Cancer Research Center/University of Washington Cancer ConsortiumPhase 3
CompletedBeclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem
NCT00489203
Fred Hutchinson Cancer CenterPhase 2
CompletedCyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis,
NCT00445744
Fred Hutchinson Cancer CenterN/A
TerminatedSunitinib in Treating Patients With Idiopathic Myelofibrosis
NCT00387426
National Cancer Institute (NCI)Phase 2
Completed3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia,
NCT00381550
National Cancer Institute (NCI)Phase 2
TerminatedReversible Secondary Myelofibrosis or Clonal Myeloproliferative Disorder
NCT00722254
University of Utah
CompletedLithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem
NCT00408681
Fred Hutchinson Cancer CenterN/A
CompletedBelinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases
NCT00351975
National Cancer Institute (NCI)Phase 1
CompletedVorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or M
NCT00357305
National Cancer Institute (NCI)Phase 1
CompletedFludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treati
NCT00397813
Fred Hutchinson Cancer CenterPhase 2
CompletedLenalidomide and Prednisone in Treating Patients With Myelofibrosis
NCT00227591
National Cancer Institute (NCI)Phase 2
Active Not RecruitingDecitabine in Treating Patients With Myelofibrosis
NCT00095784
National Cancer Institute (NCI)Phase 2
CompletedTacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone To
NCT00089011
Fred Hutchinson Cancer CenterPhase 2
CompletedTipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia
NCT00047190
National Cancer Institute (NCI)Phase 2
CompletedImatinib Mesylate in Treating Patients With Myelofibrosis
NCT00039416
National Cancer Institute (NCI)Phase 2
CompletedImatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction
NCT00025415
National Cancer Institute (NCI)Phase 1
CompletedThalidomide in Treating Patients With Myelofibrosis
NCT00015821
National Cancer Institute (NCI)Phase 2
CompletedFludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenola
NCT00112593
Fred Hutchinson Cancer CenterN/A
No Longer AvailableManaged Access Program for Momelotinib in Myelofibrosis
NCT05582083
GlaxoSmithKline