| Recruiting | Observational Study to Evaluate the Efficacy of Sustained QUTENZA® Use in Painful Diabetic Peripheral Neuropat NCT06495424 | Averitas Pharma, Inc. | — |
| Recruiting | SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease NCT06480786 | University of Nebraska | N/A |
| Completed | Feasibility of Self-treatment of Painful Diabetic Neuropathy Using Electrical Vasomotor Nerve Stimulation NCT06524284 | Neurecon BV | N/A |
| Not Yet Recruiting | A Study to Evaluate Pregabalin in Painful Diabetic Peripheral Neuropathy NCT06383702 | CSPC Ouyi Pharmaceutical Co., Ltd. | Phase 3 |
| Active Not Recruiting | Multimodal Intervention for Painful Diabetic Neuropathy: NeuOst Feasibility Trial NCT06423391 | University College of Osteopathy | N/A |
| Unknown | Treatment for Painful Diabetic Neuropathy NCT05937984 | McMaster University | N/A |
| Terminated | BurstDR Stimulation for Painful Diabetic Neuropathy NCT05985291 | Wake Forest University Health Sciences | — |
| Recruiting | Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA NCT05754190 | Brown University | — |
| Active Not Recruiting | Pain and Neurological Function Improvements With 10 kHz Spinal Cord Stimulation Treatment of Painful Diabetic NCT05777317 | Nevro Corp | N/A |
| Completed | Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study NCT05993871 | Tanta University | — |
| Completed | Axon Therapy and Conventional Medical Management for Painful Diabetic Neuropathy Compared to Sham and Conventi NCT05620225 | NeuraLace Medical, Inc. | N/A |
| Completed | EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA NCT05480228 | James P. Rathmell, MD | Phase 2 |
| Completed | EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy NCT05476276 | James P. Rathmell, MD | Phase 2 |
| Unknown | The Therapeutic Effect of Low-intensity Focused Ultrasound on Painful Diabetic Peripheral Neuropathy NCT05624762 | Chongqing Medical University | N/A |
| Unknown | Microvascular Dysfunction in Diabetic Peripheral Neuropathy NCT05118217 | University of Plymouth | — |
| Unknown | Vitamin D and Painful Diabetic Neuropathy NCT05080530 | Baqai Institute of Diabetology and Endocrinology | N/A |
| Completed | Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN NCT04857957 | Centrexion Therapeutics | Phase 1 |
| Recruiting | Low-Dose Naltrexone for the Treatment of Painful Diabetic Neuropathy NCT04678895 | Dartmouth-Hitchcock Medical Center | Phase 2 |
| Completed | A 12-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Painful Peripheral N NCT04786340 | WinSanTor, Inc | Phase 2 |
| Unknown | The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patie NCT04689971 | Duta Wacana Christian University | Phase 2 / Phase 3 |
| Unknown | The Benefits of Vitamin D 5000 IU as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient NCT04689958 | Duta Wacana Christian University | Phase 2 / Phase 3 |
| Unknown | The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient NCT04689984 | Duta Wacana Christian University | Phase 2 / Phase 3 |
| Recruiting | Peripheral Nerve Block in Patients With Painful Diabetic Polyneuropathy NCT04699734 | University of Aarhus | N/A |
| Withdrawn | Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy -The HOPES Trial NCT04087941 | Brigham and Women's Hospital | Phase 2 |
| Completed | A 24-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Peripheral Neuropath NCT04005287 | WinSanTor, Inc | Phase 2 |
| Completed | Injection of Subcutaneous Glucose 10% in Small Shots is Effective in the Treatment of Diabetic Neuropathic Pai NCT04097691 | Ministry of Health and Population, Egypt | — |
| Completed | Extension of Phase 3 Gene Therapy for Painful Diabetic Neuropathy NCT04055090 | Helixmith Co., Ltd. | Phase 3 |
| Completed | Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy NCT03749642 | Aziende Chimiche Riunite Angelini Francesco S.p.A | Phase 2 |
| Completed | Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation NCT03769675 | Mayo Clinic | N/A |
| Terminated | Efficacy and Safety of MEDI7352 in Participants With Painful Diabetic Neuropathy NCT03755934 | AstraZeneca | Phase 2 |
| Unknown | The Development of Contextual Cognitive Behavioural Approach to PDN NCT03700528 | King's College London | N/A |
| Terminated | Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN) NCT03297294 | Novartis Pharmaceuticals | Phase 2 |
| Unknown | An Evaluation of an SCCD on the Symptomatology of Painful DPN NCT03331614 | Rosenblum, Jonathan I., DPM | N/A |
| Unknown | Comparison of 10 kHz SCS Combined With CMM to CMM Alone in the Treatment of Neuropathic Limb Pain NCT03228420 | Nevro Corp | N/A |
| Completed | Graded Exposure in Patients With Painful Diabetic Neuropathy NCT03066570 | Maastricht University Medical Center | N/A |
| Completed | Trazodone in Painful Diabetic Neuropathy NCT03202979 | Aziende Chimiche Riunite Angelini Francesco S.p.A | Phase 2 |
| Unknown | Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy NCT03700502 | Nanjing First Hospital, Nanjing Medical University | — |
| Completed | Phase 3 Gene Therapy for Painful Diabetic Neuropathy NCT02427464 | Helixmith Co., Ltd. | Phase 3 |
| Completed | The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to T NCT02643251 | BioDelivery Sciences International | Phase 2 |
| Completed | A Safety Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Painful Diabetic Neuropathy NCT02355158 | BioDelivery Sciences International | Phase 2 |
| Completed | Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropath NCT02068027 | BioDelivery Sciences International | Phase 2 |
| Completed | A Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study for the Pain of Diabetic Peripheral NCT01521598 | SK Life Science, Inc. | Phase 2 |
| Terminated | Eslicarbazepine Acetate as Therapy in Diabetic Neuropathic Pain NCT01129960 | Bial - Portela C S.A. | Phase 3 |
| Terminated | A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y NCT01056315 | Grünenthal GmbH | Phase 2 |
| Unknown | Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy NCT01125215 | Mahidol University | Phase 2 / Phase 3 |
| Withdrawn | A Study of Single Dose Pain Therapy in Patients With Painful Diabetic Neuropathy (0000-115) NCT00837941 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Efficacy of Inhaled Cannabis in Diabetic Painful Peripheral Neuropathy NCT00781001 | Center for Medicinal Cannabis Research | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy NCT00695565 | Arcion Therapeutics Inc | Phase 2 |
| Completed | Study on the Role of Decompression of Lower Extremity Nerves for the Treatment of Patients With Symptomatic Di NCT00703209 | University of Texas Southwestern Medical Center | N/A |
| Completed | Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Painful Diabetic Neuropathy NCT00980746 | Bial - Portela C S.A. | Phase 2 |
| Completed | A Trial to Assess the Efficacy and Safety of 400mg/Day Lacosamide in Subjects With Painful Diabetic Neuropathy NCT00350103 | UCB Pharma | Phase 3 |
| Completed | A Trial to Assess the Long-term Safety and Efficacy of Lacosamide in Subjects With Painful Diabetic Neuropathy NCT00220337 | UCB Pharma | Phase 3 |
| Completed | Study Evaluating Long-term Safety and Efficacy of Lacosamide in Subjects With Painful Distal Diabetic Neuropat NCT00546351 | UCB Pharma | Phase 3 |
| Completed | An Open-label follow-on Trial to Assess the Long-term Safety and Efficacy of Oral SPM 927 in Subjects With Dia NCT00861042 | UCB Pharma | Phase 2 |
| Completed | Electromagnetic Stimulation (FREMS) in Patients With Painful Diabetic Neuropathy NCT00337324 | IRCCS San Raffaele | Phase 2 / Phase 3 |
| Completed | A Trial to Investigate Safety and Efficacy of SPM927 in Painful Diabetic Neuropathy NCT00861445 | UCB Pharma | Phase 2 |
| Withdrawn | A Clinical Trial to Study the Effects of GRC 17536 in Patients With Painful Diabetic Neuropathy (Painful Extre NCT01556152 | Glenmark Pharmaceuticals Ltd. India | Phase 2 |