| Recruiting | E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers NCT05639972 | Christian Hinrichs | Phase 1 / Phase 2 |
| Withdrawn | Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia NCT06276946 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Recruiting | A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Canc NCT07063212 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer NCT07033091 | The Institute of Molecular and Translational Medicine, Czech Republic | N/A |
| Recruiting | Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly NCT06309225 | Omar Mahmoud | N/A |
| Recruiting | Lymphocyte-Sparing And Radio-Immunotherapy in Head and Neck Carcinoma NCT06706401 | Centre Leon Berard | Phase 3 |
| Recruiting | Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcin NCT06563362 | University of Zurich | Phase 2 |
| Withdrawn | Feasibility of Adaptive Radiation Therapy for Human-papilloma Virus-positive Oropharyngeal Cancer Patients on NCT05849142 | University of Miami | N/A |
| Active Not Recruiting | Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples? NCT06592716 | Rigshospitalet, Denmark | — |
| Recruiting | Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SA NCT06088381 | University of Maryland, Baltimore | Phase 2 |
| Recruiting | Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx C NCT05787639 | University of California, San Diego | Phase 2 |
| Withdrawn | A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor NCT04892875 | Jennifer Choe | Phase 1 |
| Active Not Recruiting | Trial of Individualized Adaptive RT in HPV-related High Risk Oropharynx Cancer NCT06234748 | University of Michigan Rogel Cancer Center | Phase 2 |
| Recruiting | Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patien NCT05757817 | Institut Claudius Regaud | N/A |
| Recruiting | Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy NCT05793151 | Medical University of South Carolina | N/A |
| Recruiting | Arabic PRO Measures for Head and Neck Cancer Radiotherapy. NCT06662929 | King Saud University | — |
| Unknown | Real-time Targeted Fluorescence Endoscopy for Detection of the Primary Cancer Lesion in Patients With a Metast NCT06100081 | University Medical Center Groningen | N/A |
| Active Not Recruiting | The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors NCT05798780 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Recruiting | Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer NCT05800574 | Fox Chase Cancer Center | Phase 2 |
| Recruiting | E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers NCT05686226 | Christian Hinrichs | Phase 2 |
| Completed | Surgeon-performed Outpatient Transoral and Transcervical Ultrasound of the Oropharynx NCT05696314 | Rigshospitalet, Denmark | N/A |
| Withdrawn | Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma NCT05535023 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropha NCT05388773 | Heath Skinner | Phase 2 |
| Recruiting | A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With H NCT05307939 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | Staying Connected: a Mobile Health Study With the Noona® and Mobili-T® Systems NCT05368025 | University of Alberta | — |
| Completed | Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis NCT05369234 | Covenant Health Cancer Center | Phase 3 |
| Completed | Outpatient Ultrasound for the Diagnostic Work-up of Oropharynx Cancer NCT05698667 | Rigshospitalet, Denmark | N/A |
| Unknown | Immunological Function After Radiation With Either Proton or Photon Therapy NCT06016699 | University Medical Center Groningen | — |
| Completed | Study of Lymphatic Drainage Mapping in Oropharyngeal Cancers NCT05055206 | University Health Network, Toronto | N/A |
| Recruiting | Adaptive RadioTherapy for OroPharynx Cancer NCT04901234 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 2 |
| Recruiting | Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy NCT05337631 | University Hospital Freiburg | — |
| Recruiting | Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx NCT04667585 | Duke University | N/A |
| Unknown | Bitter Taste Receptors in Oropharynx Cancer NCT05211427 | Thomas Hummel | N/A |
| Active Not Recruiting | Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110) NCT04609280 | University of Maryland, Baltimore | Phase 2 |
| Active Not Recruiting | Circulating Biomarkers in Oropharyngeal Cancers NCT05904327 | Region Örebro County | — |
| Completed | Collagen Matrix in Oral Cancer Surgery NCT07337122 | SAYAH Charline | — |
| Recruiting | Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal NCT04444869 | University of Missouri-Columbia | Phase 2 |
| Completed | Proteome- and Methylation Profiles in Oropharyngeal Cancer NCT04567082 | Aalborg University Hospital | — |
| Unknown | QUantitative Assessment of Swallowing After Radiation (QUASAR) NCT04359199 | Loren Mell, MD | — |
| Terminated | Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors NCT04301011 | Turnstone Biologics, Corp. | Phase 1 |
| Recruiting | Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer NCT04178174 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 3 |
| Withdrawn | Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients NCT04001413 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Recruiting | De-escalation of Adjuvant Radiation for Low-Risk HPV Oropharyngeal Cancers NCT06554158 | Georgetown University | N/A |
| Completed | Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer NCT03838263 | UNICANCER | Phase 2 |
| Unknown | Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth NCT03874572 | Rigshospitalet, Denmark | Phase 1 |
| Active Not Recruiting | Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma NCT04124198 | Christian von Buchwald | N/A |
| Completed | Outcomes of Prophylactic Swallowing Therapy in Patients Undergoing Definitive Chemoradiation for Head and Neck NCT03435471 | University of Miami | N/A |
| Recruiting | Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Cancer. NCT04277858 | Nader Sadeghi | Phase 2 |
| Active Not Recruiting | De-Escalation Protocol Of HPV Mediated Oropharyngeal Squamous Cell Carcinoma NCT04638465 | Nebraska Methodist Health System | — |
| Completed | Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer NCT03416153 | University of Michigan Rogel Cancer Center | Phase 2 |
| Completed | PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients NCT03342378 | University of Wisconsin, Madison | — |
| Active Not Recruiting | Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer NCT03383094 | Loren Mell, MD | Phase 2 |
| Completed | Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Thera NCT03418792 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Active Not Recruiting | Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Car NCT03174275 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |
| Completed | New Modalities for Detection of Oropharyngeal Cancer NCT03226613 | Vanderbilt University Medical Center | N/A |
| Completed | Gabapentin for the Reduction of Radiation Therapy Induced Pain During the Treatment of Oropharyngeal Cancer NCT03269344 | Henry Ford Health System | Phase 3 |
| Unknown | Functional Outcome After Treatment for Oropharyngeal Squamous Cell Carcinoma NCT03418909 | Rigshospitalet, Denmark | — |
| Completed | Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinom NCT03082534 | University of California, San Diego | Phase 2 |
| Completed | Adaptive Radiotherapy for Head and Neck Cancer NCT03096808 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Unknown | Cell-free Tumor DNA in Head and Neck Cancer Patients NCT03942380 | Christian von Buchwald | N/A |
| Completed | Physiological Flow of Liquids in Head and Neck Cancer Patients: A Pilot Study NCT04112940 | University Health Network, Toronto | — |
| Completed | CaptHPV : Validation of the Method "CaptHPV" for the Diagnosis of Human Papillomavirus Associated Infiltrating NCT02981862 | Institut de Cancérologie de Lorraine | N/A |
| Completed | Evaluation of De-escalated Adjuvant Radiation Therapy for Human Papillomavirus (HPV)-Associated Oropharynx Can NCT02908477 | Mayo Clinic | Phase 3 |
| Completed | Pembrolizumab in Combination With CRT for LA-SCCHN NCT02586207 | Sanford Health | Phase 1 |
| Completed | Multispectral Imaging to Characterize Patterns of Vascular Supply Within Lymphoepithelial Mucosa in Oropharyng NCT02365844 | Stanford University | — |
| Completed | Adaptative Radiotherapy to Decrease Xerostomia in Oropharynx Carcinoma (ARTOME) NCT05025618 | Center Eugene Marquis | — |
| Completed | Adaptative Radiotherapy to Decrease Xerostomia in Oropharynx Carcinoma NCT01874587 | Center Eugene Marquis | Phase 3 |
| Completed | Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Random NCT01173692 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | TPF-Induction Chemotherapy of Oropharyngeal and Cavity of the Mouth Cancer NCT01108042 | Orlando Guntinas-Lichius, Prof. Dr. med. | Phase 1 / Phase 2 |
| Terminated | Prevention of Radiation-induced Severe Oral Mucositis in Oral Cavity, Oropharynx, Hypopharynx, and Cavum Cance NCT01066741 | Centre Leon Berard | Phase 3 |
| Terminated | OraTest in Combination With Visual Examination and Visual Examination Alone NCT00537199 | M.D. Anderson Cancer Center | Phase 3 |
| Unknown | Postoperative Radiotherapy According to Molecular Analysis of Surgical Margins of Oral and Oropharyngeal SCC NCT00232960 | Gustave Roussy, Cancer Campus, Grand Paris | N/A |
| Completed | IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC NCT00158678 | Groupe Oncologie Radiotherapie Tete et Cou | Phase 3 |
| Completed | Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC NCT00158652 | Groupe Oncologie Radiotherapie Tete et Cou | Phase 3 |
| Completed | Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC NCT00162708 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 2 / Phase 3 |
| Terminated | Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cance NCT00080028 | Pharmacyclics LLC. | Phase 1 |