| Recruiting | Efgartigimod for the Treatment of Acute Optic Neuritis NCT06453694 | Anastasia Vishnevetsky, MD, MPH | Phase 2 |
| Recruiting | Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX) NCT07100990 | Mayo Clinic | Phase 3 |
| Not Yet Recruiting | Evaluation of Optic Neuritis Using Synthetic Quantitative MRI NCT06916182 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Recruiting | Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis NCT06389968 | Technical University of Munich | N/A |
| Completed | Building Research With Artificial Intelligence in Neuro-Ophthalmology NCT06390579 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Recruiting | VIsual Pathways Model in Neuro-inflammatory Disorders NCT05487989 | University Hospital, Lille | — |
| Unknown | Fampridine-SR and Optic Neuritis Recovery NCT04148781 | Courtney Casserly | EARLY_Phase 1 |
| Recruiting | Edaravone in the Treatment of Optic Neuritis NCT05540262 | First Affiliated Hospital of Guangxi Medical University | N/A |
| Unknown | Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis Trial NCT04942002 | Asociación para Evitar la Ceguera en México | Phase 2 / Phase 3 |
| Completed | OCS-05 in Patients With Optic Neuritis NCT04762017 | Oculis | Phase 2 |
| Completed | Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics NCT04289909 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis NCT03963310 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Unknown | Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Ac NCT05605951 | Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecul | — |
| Unknown | Epidemiologic and Clinical Characteristics of Optic Neuritis in China NCT04257734 | Chinese PLA General Hospital | — |
| Recruiting | Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD) NCT05017142 | University of Bern | — |
| Unknown | Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy. NCT05353413 | Medical University of Bialystok | N/A |
| Terminated | Diagnosis of ON With or Without MS or NMOSD NCT04131764 | Jagannadha R Avasarala | — |
| Unknown | Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis NCT04042363 | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | N/A |
| Unknown | Optic Neuritis Differential Diagnosis Study NCT03370965 | University Hospital Center of Martinique | N/A |
| Unknown | Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis NCT03586557 | Chinese PLA General Hospital | N/A |
| Completed | BN201 SAD MAD Study in Healthy Subjects NCT03630497 | Accure Therapeutics | Phase 1 |
| Completed | Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin NCT03345537 | Nantes University Hospital | — |
| Recruiting | Retinal Neuro-vascular Coupling in Patients With Multiple Sclerosis NCT03401879 | Medical University of Vienna | N/A |
| Completed | The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CIS NCT03451955 | University of Copenhagen | N/A |
| Completed | Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON) NCT04793087 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | 3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON) NCT04792866 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Ne NCT03570385 | Rennes University Hospital | N/A |
| Terminated | High-Dose Vitamin D Induction in Optic Neuritis NCT03302585 | University of Calgary | Phase 2 |
| Completed | Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis NCT02939937 | Tehran University of Medical Sciences | Phase 2 |
| Recruiting | Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) NCT02521311 | University of California, San Francisco | Phase 2 |
| Terminated | Gypenosides Treatment for Optic Neuritis NCT02976766 | First Affiliated Hospital of Guangxi Medical University | Phase 2 |
| Completed | Optic Neuritis and Ganglion Cell Layer NCT02864134 | CHU de Quebec-Universite Laval | — |
| Completed | Pupillometry Dynamic Measures in Patients Without Ocular or Neurological Disease NCT02894281 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic Neuritis NCT03651362 | University Hospital, Lille | — |
| Completed | Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial NCT01962571 | University Eye Hospital, Freiburg | Phase 3 |
| Unknown | The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset NCT02886377 | Xiujuan Zhao | — |
| Completed | Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis NCT01987167 | Neuro-Ophthalmologic Associates, PC | EARLY_Phase 1 |
| Completed | Ocular Manifestations in Rheumatic Diseases NCT03753893 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Completed | Amiloride Clinical Trial In Optic Neuritis NCT01802489 | University of Oxford | Phase 2 |
| Completed | Interest of Dynamic Measures of the Pupil in Optic Neuritis NCT02004054 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Optical Coherence Tomography in Multiple Sclerosis Patients NCT01774123 | The Cleveland Clinic | — |
| Active Not Recruiting | The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders NCT01623076 | University of Texas Southwestern Medical Center | — |
| Completed | Optic Neuritis Recovery After Oral or IV Corticosteroids NCT01524250 | London Health Sciences Centre | Phase 2 / Phase 3 |
| Completed | Neuroprotection With Phenytoin in Optic Neuritis NCT01451593 | University College, London | Phase 2 |
| Unknown | Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography NCT01465893 | Isfahan University of Medical Sciences | Phase 2 |
| Completed | Ampyra for Optic Neuritis in Multiple Sclerosis NCT01337986 | Washington University School of Medicine | Phase 2 / Phase 3 |
| Completed | Lipoic Acid as a Treatment for Acute Optic Neuritis NCT01294176 | Oregon Health and Science University | Phase 1 |
| Completed | Visual Reconstitution Therapy After Optic Neuritis NCT01274702 | Friedemann Paul | Phase 2 |
| Terminated | Neuroprotection and Repair in Optic Neuritis NCT01073813 | University of Calgary | Phase 2 |
| Completed | A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on NCT00856635 | Teva Branded Pharmaceutical Products R&D, Inc. | Phase 3 |
| Terminated | Atacicept in Subjects With Optic Neuritis NCT00624468 | EMD Serono | Phase 2 |
| Unknown | Simvastatin Treatment of Patients With Acute Optic Neuritis NCT00261326 | Glostrup University Hospital, Copenhagen | Phase 3 |
| Completed | Safety and Efficacy Study of Erythropoietin as add-on Therapy of Methylprednisolone to Treat Acute Optic Neuri NCT00355095 | Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH | Phase 2 |
| Completed | TLR-9 Antagonism in Steroid Resistant Optic Neuritis NCT01424735 | Sudhalkar Eye Hospital | N/A |
| Active Not Recruiting | Biobank For MS And Other Demyelinating Diseases NCT00445367 | Accelerated Cure Project for Multiple Sclerosis | — |
| Withdrawn | Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to I NCT00037115 | MidAmerica Neuroscience Research Foundation at Rowe Neurology Institute | Phase 4 |
| Completed | Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis NCT00179478 | Beth Israel Deaconess Medical Center | Phase 4 |
| Completed | Intravenous Immunoglobulin Therapy in Optic Neuritis NCT00000117 | National Eye Institute (NEI) | Phase 3 |
| Unknown | Optic Neuritis Treatment Trial (ONTT) NCT00000146 | National Eye Institute (NEI) | Phase 3 |
| Unknown | Longitudinal Optic Neuritis Study (LONS) NCT00000147 | National Eye Institute (NEI) | N/A |