NCT01424735

TLR-9 Antagonism in Steroid Resistant Optic Neuritis

Outcomes of TLR-9 Antagonism in Steroid Resistant Optic Neuritis; A Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Sudhalkar Eye Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.

Conditions

• Optic Neuritis

Interventions

Type	Name	Description
DRUG	Mycobacterium w.(Mw)-freeze dried extract 0.5ml	0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration

Timeline

• Start date: 2006-07-01
• Primary completion: 2010-01-01
• Completion: 2010-05-01
• First posted: 2011-08-29
• Last updated: 2011-08-29

Locations

1 site across 1 country: India