Trials / Terminated
TerminatedNCT01073813
Neuroprotection and Repair in Optic Neuritis
Developing Neuroprotection and Repair Strategies in MS: Phase IIa Randomized, Controlled Trial of Minocycline in Acute Optic Neuritis (ON)
- Status
- Terminated
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 6 (actual)
- Sponsor
- University of Calgary · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
The primary aim of this open-label pilot trial is to estimate the treatment effect of 100 mg of oral minocycline twice daily for 90 days, initiated within 30 days of onset of ON, on functional and structural optic nerve recovery compared to no treatment. The primary outcome measure that will be used to measure optic nerve recovery is retinal nerve fibre layer (RNFL) thickness. Other objectives: Secondary outcomes are temporal RNFL thickness, macular volume, and visual outcomes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Minocycline | 100mg twice daily |
Timeline
- Start date
- 2010-02-01
- Primary completion
- 2011-12-01
- Completion
- 2013-01-01
- First posted
- 2010-02-23
- Last updated
- 2013-01-23
Source: ClinicalTrials.gov record NCT01073813. Inclusion in this directory is not an endorsement.