| Not Yet Recruiting | Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Di NCT07079826 | Payel Roy | N/A |
| Recruiting | CEDRN: Opioid Registry NCT07466784 | University of British Columbia | — |
| Recruiting | Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder NCT06487533 | Spark Biomedical, Inc. | — |
| Recruiting | ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chroni NCT06442566 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Withdrawn | Suboxone Dispenser for OUD NCT05790551 | Addinex Technologies, Inc. | N/A |
| Unknown | Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction NCT03813095 | Aphios | Phase 2 |
| Recruiting | Understanding the Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain NCT05555485 | The University of Texas Medical Branch, Galveston | N/A |
| Active Not Recruiting | Sublingual Dexmedetomidine for Treating Opioid Withdrawal NCT05712707 | New York State Psychiatric Institute | Phase 1 / Phase 2 |
| Active Not Recruiting | Evaluating Buspirone to Treat Opioid Withdrawal NCT05511909 | Johns Hopkins University | Phase 2 |
| Unknown | Evaluating the Pharmacokinetics and Patient Outcomes of Buprenorphine Microdosing NCT05307458 | United Health Services Hospitals, Inc. | — |
| Completed | Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder NCT05053503 | Spark Biomedical, Inc. | N/A |
| Terminated | Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal i NCT04759703 | Massachusetts General Hospital | Phase 2 / Phase 3 |
| Withdrawn | Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER) NCT04740099 | Unity Health Toronto | N/A |
| Recruiting | Assessing a Clinically-meaningful Opioid Withdrawal Phenotype NCT05027919 | University of Maryland, Baltimore | Phase 2 |
| Completed | Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal NCT04731935 | Spark Biomedical, Inc. | N/A |
| Completed | Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal NCT04218240 | University of Pennsylvania | Phase 2 |
| Completed | An Innovative Intervention for OUD Treatment NCT04325659 | Johns Hopkins University | Phase 2 / Phase 3 |
| Completed | Oral Cannabidiol for Opioid Withdrawal NCT04238754 | Johns Hopkins University | Phase 1 / Phase 2 |
| Completed | Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal NCT04470050 | BioXcel Therapeutics Inc | Phase 1 / Phase 2 |
| Completed | Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal NCT04075214 | Spark Biomedical, Inc. | N/A |
| Terminated | BRIDGE Device for Treatment of Opioid Withdrawal NCT04162145 | BrightView LLC | N/A |
| Withdrawn | Comparison of Three Opioid Detoxification Treatment Regimens NCT03678792 | University of Alabama at Birmingham | Phase 3 |
| Completed | Opioid Tapering After Spine Surgery NCT04140955 | Aarhus University Hospital | N/A |
| Completed | Assessing Opioid Care Practices Using CPV Patient Simulation Modules NCT04080037 | Qure Healthcare, LLC | N/A |
| Completed | Lofexidine for Adults Undergoing Lumbar Spine Surgery NCT04126083 | Mayo Clinic | Phase 4 |
| Completed | Maternal Opioid Treatment: Human Experimental Research - Data Yield Appropriate Decisions NCT04049799 | University of Vermont | — |
| Completed | Medical Management of Sleep Disturbance During Opioid Tapering NCT03789214 | Johns Hopkins University | Phase 2 |
| Completed | Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal NCT03489161 | Virginia Commonwealth University | EARLY_Phase 1 |
| Active Not Recruiting | Tapering From Long-term Opioid Therapy in Chronic Pain Population. Randomized Controlled Trial With 12 Months NCT03485430 | Lund University Hospital | N/A |
| Completed | Oxytocin Treatment of Opioid Dependence NCT02548728 | University of North Carolina, Chapel Hill | Phase 1 / Phase 2 |
| Completed | Open-Label, Safety Study of Lofexidine NCT02363998 | USWM, LLC (dba US WorldMeds) | Phase 3 |
| Completed | Pregabalin for Opiate Withdrawal Syndrome NCT03017430 | St. Petersburg Bekhterev Research Psychoneurological Institute | Phase 4 |
| Completed | Buprenorphine in the Emergency Department NCT03174067 | St. Joseph's Health Centre Toronto | Phase 4 |
| Completed | 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence NCT01549652 | Stanford University | N/A |
| Completed | Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individuals NCT01262092 | University of Arkansas | Phase 2 |