| Recruiting | Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites NCT06837220 | University of Chicago | N/A |
| Recruiting | Temporal Interference Methods for Addiction Treatment NCT07210268 | Indiana University | N/A |
| Recruiting | Effects of Novel E-cigarette Constituents on Adults TCORS 3.0 NCT05932745 | Yale University | N/A |
| Recruiting | Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behavior NCT05994209 | Washington University School of Medicine | Phase 1 |
| Recruiting | tDCS Plus Varenicline for Smoking Cessation NCT06798324 | Centre for Addiction and Mental Health | Phase 4 |
| Recruiting | Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity NCT06695884 | Rutgers, The State University of New Jersey | N/A |
| Recruiting | Real-time eCounselling for Nicotine Addiction NCT06544057 | Overcome | N/A |
| Completed | A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults NCT05897242 | Fred Hutchinson Cancer Center | N/A |
| Unknown | Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nico NCT06170138 | Amplicon AB | N/A |
| Recruiting | Identify the Optimal TMS Target to Modulate Reward Activity NCT05766254 | Rutgers, The State University of New Jersey | N/A |
| Recruiting | Smoking Cessation and Menstrual Cycle Phase NCT05515354 | Centre for Addiction and Mental Health | Phase 4 |
| Completed | Effects of E-cigarette Flavors on Youth TCORS 2.0 NCT03634839 | Yale University | Phase 1 |
| Recruiting | Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking NCT05181891 | Washington State University | Phase 2 |
| Completed | Evaluation of the Addictive Potential of E-Cigarettes NCT04772014 | Central Institute of Mental Health, Mannheim | — |
| Completed | Acute Effects of TCIG vs ECIG in PLWH NCT04568395 | University of California, Los Angeles | N/A |
| Completed | Families With Substance Use and Psychosis: A Pilot Study NCT04284813 | Mclean Hospital | N/A |
| Terminated | Temporal Interference Neurostimulation and Addiction NCT04432064 | Indiana University | N/A |
| Unknown | Cortical Excitability and Role of rTMS in Nicotine Use Disorder NCT03264755 | Assiut University | N/A |
| Completed | Effects of E-Cigarette Flavors on Adults TCORS 2.0 NCT03635333 | Yale University | Phase 1 |
| Completed | Behavioral Memory Modulation in Nicotine Addiction NCT03744559 | Medical University of South Carolina | N/A |
| Completed | Neural Basis of Eating Behavior in Abstinent Smokers NCT03438188 | University of Pennsylvania | N/A |
| Completed | Neurobiology of Alcohol and Nicotine Co-Addiction NCT03338933 | VA Office of Research and Development | — |
| Terminated | Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment NCT03213418 | New York State Psychiatric Institute | N/A |
| Completed | Real Time fMRI and Quitting Smoking NCT03302026 | University of Pennsylvania | N/A |
| Terminated | Accelerated rTMS for the Reduction of Nicotine Craving NCT03352609 | Medical University of South Carolina | N/A |
| Completed | Helping Poor Smokers Quit NCT03194958 | Washington University School of Medicine | N/A |
| Withdrawn | Nicotine Virtual Reality Conditioned Place Preference NCT06259630 | University of Chicago | Phase 4 |
| Completed | Pharmacokinetics and Acute Effects of Multiple Dose of Nicotine: Electronic Cigarette and Cigarette NCT02511704 | Parc de Salut Mar | Phase 1 |
| Unknown | Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers NCT00429208 | Hadassah Medical Organization | N/A |
| Terminated | Baclofen Effects on Smoking Urge and Withdrawal NCT00257894 | VA Office of Research and Development | Phase 2 |
| Completed | Combined Pharmaco/Behavior Therapy in Adolescent Smokers NCT00330187 | Medical University of South Carolina | Phase 2 |