NCT03634839

Effects of E-cigarette Flavors on Youth TCORS 2.0

Effects of E-cigarette Flavors on Youth

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 20 Years
• Healthy volunteers: Not accepted

Summary

This study is an examination of the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth.

Detailed description

Researchers will examine the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth. Participants will rate the flavor intensity, coolness, sweetness, and irritation experienced using validated rating scales. Forty youth (18-20 years of age) who have experience with e-cigarettes and will participate in 1 laboratory session. They will receive 1 nicotine concentrations (36mg/ml nicotine salt) during the session; during the session they will be exposed, in random order, to sweet (watermelon) and sweet-cooling (watermelon-menthol) flavors combined with the assigned session nicotine concentration.

Conditions

• Nicotine Use Disorder

Interventions

Type	Name	Description
DRUG	Flavoring Agents	Flavor of e-liquid - sweet or tobacco
DRUG	Nicotine	Nicotine level (36 mg/ml)

Timeline

• Start date: 2022-11-07
• Primary completion: 2023-06-16
• Completion: 2023-07-20
• First posted: 2018-08-17
• Last updated: 2024-08-09
• Results posted: 2024-08-09

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study