NCT05932745

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

Detailed description

The investigators will examine the influence of cooling components of WS-3, WS-23 (synthetic coolants) and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults. Participants will rate the flavor intensity, coolness, sweetness, and irritation/harshness, bitterness experienced using validated rating scales. 66 adult participants (18+ years of age) who are current e-cigarette users will participate in 3 laboratory sessions. Participants will be randomized to receive one of the 3 menthol conditions (no-menthol, low menthol, high menthol) in Lab 1 and will receive the alternative conditions in randomized order in Lab 2 and Lab 3. During each lab session the menthol condition will be paired with three WS-3 concentrations: no WS-3, low (0.1%) WS-3, or high (2.0%) WS-3 and three WS-23 concentrations: low (0.1%) WS-23, high (2.0%) WS-23, or 4% WS-23 in randomized order. All e-cigarettes will contain nicotine salt at a nicotine concentration of \~59mg/ml and all participants will be exposed to eighteen conditions across 3 lab sessions.

Conditions

• Nicotine Use Disorder

Interventions

Type	Name	Description
OTHER	E-liquid coolant (No WS-3) for non-menthol (1)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
OTHER	E-liquid coolant (No WS-3) for low (0.1%) menthol (1)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
OTHER	E-liquid coolant (No WS-3) for high (2.0%) menthol (1)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
OTHER	E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.
OTHER	E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.
OTHER	E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.
OTHER	E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.
OTHER	E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.
OTHER	E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.
OTHER	E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.
OTHER	E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.
OTHER	E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.
OTHER	E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.
OTHER	E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.
OTHER	E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.
OTHER	E-liquid coolant (4% WS-23) for non-menthol (6)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.
OTHER	E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.
OTHER	E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)	Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

Timeline

• Start date: 2025-06-20
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2023-07-06
• Last updated: 2025-12-26

Locations

1 site across 1 country: United States