| Not Yet Recruiting | Non-Invasive Deep Brain Neuromodulation for Smoking Cessation NCT07298902 | The University of Texas Health Science Center, Houston | N/A |
| Recruiting | Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches NCT07165808 | Emory University | N/A |
| Not Yet Recruiting | Semaglutide for Smoking Cessation in Patients With Diabetes NCT07059377 | Ottawa Heart Institute Research Corporation | Phase 3 |
| Recruiting | CONNECT Cancer Survivors With Tobacco Treatment NCT07020273 | Washington University School of Medicine | N/A |
| Recruiting | Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Comm NCT06803706 | Sigmund Freud PrivatUniversitat | N/A |
| Recruiting | Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder NCT06582888 | University of California, San Diego | EARLY_Phase 1 |
| Enrolling By Invitation | Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids NCT06619964 | Rochester Institute of Technology | — |
| Completed | Examining the Efficacy of a Newly Developed Smoking Cessation Program NCT06746025 | Quit Center LLC | — |
| Completed | Sex Differences in E-cig Perception: Study 1 NCT05432830 | Yale University | N/A |
| Recruiting | Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects NCT06254001 | National Institute of Respiratory Diseases, Mexico | Phase 4 |
| Completed | A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults NCT05897242 | Fred Hutchinson Cancer Center | N/A |
| Recruiting | Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies NCT06471387 | University of Cyprus | — |
| Unknown | Effects of Exercises on Functional Capacity NCT06291584 | Kırklareli University | N/A |
| Completed | Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction NCT05903014 | Indonesia University | Phase 4 |
| Completed | Effects of Semaglutide on Nicotine Intake NCT05530577 | University of North Carolina, Chapel Hill | Phase 2 |
| Completed | Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers NCT05335915 | Johns Hopkins University | Phase 1 |
| Completed | Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency NCT05430334 | American University of Beirut Medical Center | N/A |
| Unknown | Mobile Health for Problematic Behaviors and Substance Use NCT05434429 | PredictWatch | N/A |
| Recruiting | Circuitry-Guided Smoking Cessation in Schizophrenia (UH3) NCT05276050 | The University of Texas Health Science Center, Houston | N/A |
| Active Not Recruiting | Factors Sustaining Tobacco Abstinence in Cancer Patients Treated With Radio-chemotherapy or Radiotherapy NCT06910566 | Centre Oscar Lambret | — |
| Completed | Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy NCT04126135 | Loma Linda University | Phase 4 |
| Recruiting | Biopsychosocial Predictors of Nicotine Relapse NCT06470321 | University of Cyprus | N/A |
| Completed | Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids NCT06602492 | Rochester Institute of Technology | EARLY_Phase 1 |
| Completed | Quit Smoking Study for People Who Use E-Cigarettes NCT04946825 | University of Vermont | Phase 2 |
| Completed | Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS NCT04218708 | NYU Langone Health | N/A |
| Completed | Acute Effects of Vaping Nicotine on Cognition in Young Adults NCT04901208 | Yale University | N/A |
| Completed | Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use NCT02870218 | Rose Research Center, LLC | Phase 2 |
| Withdrawn | Clinical Trial of an Innovative Digital Therapeutic for Smoking Cessation With Biochemical Verification NCT05440721 | Click Therapeutics, Inc. | N/A |
| Completed | Innovative Digital Therapeutic for Smoking Cessation NCT03694327 | My Digital Study | N/A |
| Completed | Circuitry-Guided Smoking Cessation in Schizophrenia NCT03281629 | University of Maryland, Baltimore | N/A |
| Completed | Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness NCT03069482 | Duke University | Phase 1 |
| Completed | Nicotine's Effect on Cancer Stem Cell Markers in Human Umbilical Cord Tissue NCT06678152 | Celal Bayar University | — |
| Completed | Nicotine Reinforcement and Aversion in Young Adult Light Smokers NCT01495819 | Yale University | EARLY_Phase 1 |
| Completed | Clinical Trial of Smoking Cessation Mobile Phone Program NCT02656745 | Click Therapeutics, Inc. | N/A |
| Completed | Neural Mechanisms Associated With Risk of Smoking Relapse NCT02837510 | University of Pennsylvania | N/A |
| Withdrawn | Nicotine Virtual Reality Conditioned Place Preference NCT06259630 | University of Chicago | Phase 4 |
| Completed | tDCS Effects on Resisting Smoking: Dose Ranging Study NCT02624284 | University of Pennsylvania | N/A |
| Completed | Effects of Brief Training on Craving Regulation NCT02153749 | Yale University | N/A |
| Unknown | Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings NCT02643914 | Stony Brook University | N/A |
| Completed | The END Perioperative Smoking Pilot Study NCT02482233 | University of California, San Francisco | Phase 4 |
| Completed | Acute and Chronic Nicotine Modulation of Reinforcement Learning NCT01830842 | Duke University | N/A |
| Completed | Extinction Updating in Reconsolidation NCT02154685 | Medical University of South Carolina | N/A |
| Completed | Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine NCT01944423 | University of Texas at Austin | EARLY_Phase 1 |
| Terminated | e-Cigarettes Versus NRT Gum for Smoking Cessation NCT01925781 | Creighton University | Phase 4 |
| Terminated | Effects of ABT-089 on Smoking Abstinence Symptoms and Reward NCT01756053 | University of Pennsylvania | Phase 2 |
| Completed | Nicotine Receptor Levels and Smoking Cessation NCT01788943 | University of Pennsylvania | — |
| Terminated | A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation NCT01772641 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Completed | Computer-Facilitated 5A's for Smoking Cessation in Primary Care NCT02046408 | University of California, San Francisco | N/A |
| Completed | Effects of rTMS on Cigarette Smoking and Cognition in Schizophrenia NCT01523730 | Centre for Addiction and Mental Health | N/A |
| Completed | Effect of Galantamine on Smoking Abstinence NCT01548638 | University of Pennsylvania | Phase 2 |
| Completed | Cognitive Training for Nicotine Dependence NCT01252966 | University of Pennsylvania | N/A |
| Completed | Pharmacogenetics of Nicotine Addiction Treatment NCT01314001 | University of Pennsylvania | Phase 3 |
| Completed | Nicotinic Receptor Levels After Stopping Smoking NCT01704573 | University of Pennsylvania | — |
| Completed | STOP Study: Effectiveness of Zyban in a Clinical Population NCT01015170 | Centre for Addiction and Mental Health | Phase 4 |
| Completed | Investigation of Cycloserine as a Smoking Cessation Treatment NCT01062932 | Baylor College of Medicine | Phase 1 |
| Completed | Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smok NCT01038245 | National Institute on Drug Abuse (NIDA) | — |