NCT05432830

Sex Differences in E-cig Perception: Study 1

Sex Differences in E-Cigarette Flavor Sensory Perception As It Relates to Appeal and Reinforcing Efficacy Among Adult Smokers: Study 1

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 44 Years
• Healthy volunteers: Accepted

Summary

The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.

Detailed description

This study looks at the effect of sex on the sensory effects of flavor components in e-cigarettes. Regular combustible tobacco users will sample 3 different flavored e-cigarettes containing nicotine in a human lab paradigm.

Conditions

• Nicotine Addiction
• E-Cig Use
• Cigarette Smoking
• Sex Differences

Interventions

Type	Name	Description
OTHER	E-liquid Flavor 1	E-liquid containing 36mg/ml pronated nicotine will be administered with sweet e-cigarette flavor.
OTHER	E-liquid Flavor 2	E-liquid containing 36mg/ml pronated nicotine will be administered with cooling e-cigarette flavor.
OTHER	E-liquid Flavor 3	E-liquid containing 36mg/ml pronated nicotine will be administered with unflavored e-cigarette flavor.

Timeline

• Start date: 2024-04-30
• Primary completion: 2025-07-18
• Completion: 2025-07-18
• First posted: 2022-06-27
• Last updated: 2026-01-28

Locations

1 site across 1 country: United States