Nicotine

21 registered clinical trials studyying Nicotine — 5 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Smoking Harm Reduction Using E-cigarettes and Cytisine NCT07274475	Centre for Addiction and Mental Health	N/A
Not Yet Recruiting	Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking NCT07328594	Legacy Health System	Phase 4
Active Not Recruiting	Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes NCT07459712	Philip Morris Products S.A.	N/A
Not Yet Recruiting	Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues NCT07348224	Insel Gruppe AG, University Hospital Bern	N/A
Enrolling By Invitation	Understanding Vape Marketing Study NCT07129265	Boston Children's Hospital	—
Active Not Recruiting	Nicotine Pharmacokinetics and Pharmacodynamics of Two Variants of VM 1.0 Compared to Cigarettes in Adult Curre NCT07135648	Philip Morris Products S.A.	N/A
Enrolling By Invitation	Nicotine and Cannabis Vape Labeling Experiment - Spring 2025 NCT06919276	University of Southern California	N/A
Completed	Substance Consumption, Personality, and Cognitive Functioning of Chess Players NCT06346353	Central Institute of Mental Health, Mannheim	—
Completed	Developing E-liquid Product Standards (Sweet Spot Study) NCT05864586	Ohio State University Comprehensive Cancer Center	N/A
Completed	Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes NCT04038515	Yale University	Phase 2
Completed	Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoki NCT05487456	Philip Morris Products S.A.	N/A
Completed	Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes NCT05383508	Philip Morris Products S.A.	N/A
Completed	Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Coo NCT05317195	Philip Morris Products S.A.	N/A
Completed	Behavioral Pharmacology of Cannabis and Nicotine NCT04124432	Johns Hopkins University	Phase 1
Completed	Inner Engineering Yoga Program on Short and Long Term Health Effects (ISHA-Impact): A Longitudinal Study NCT04189146	Beth Israel Deaconess Medical Center	N/A
Terminated	QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit A NCT03576768	Medical University of South Carolina	N/A
Withdrawn	The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study NCT03010995	University of Louisville	Phase 1
Completed	Switching to Low Oxidant Content Cigarettes in Adult Smokers NCT03102931	Milton S. Hershey Medical Center	N/A
Completed	The Effect of Nicotine Delivery Rate on Reinforcement NCT03134339	Yale University	EARLY_Phase 1
Completed	Nicotinic Modulation of the Default Network NCT01223404	University of Maryland, Baltimore	N/A
Completed	Nicotine and Brain Imaging Research Study NCT01227343	University of Pennsylvania	—