| Not Yet Recruiting | my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults NCT07516353 | Dana-Farber Cancer Institute | N/A |
| Not Yet Recruiting | B7-H3.CD28Z.CART in CNS Neoplasms NCT07390539 | Robbie Majzner | Phase 1 |
| Not Yet Recruiting | Comparison of Neurocognitive Outcome in Two Standard Regimen for Treatment of Low-risk Medulloblastoma NCT07291102 | Nationwide Children's Hospital | Phase 3 |
| Not Yet Recruiting | PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline NCT06639607 | Washington University School of Medicine | Phase 1 / Phase 2 |
| Not Yet Recruiting | Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease NCT07346157 | Sabine Mueller, MD, PhD | Phase 1 / Phase 2 |
| Recruiting | CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation NCT07085325 | St. Jude Children's Research Hospital | — |
| Not Yet Recruiting | Pharmacoscopy for Patients With Refractory Primary Brain Tumors NCT06804655 | University of Zurich | Phase 2 |
| Recruiting | Digoxin Medulloblastoma Study NCT06701812 | H. Lee Moffitt Cancer Center and Research Institute | Phase 2 |
| Recruiting | GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults NCT07087002 | Stanford University | Phase 1 |
| Not Yet Recruiting | Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas NCT06323408 | University Hospital Regensburg | — |
| Recruiting | Atovaquone Combined With Radiation in Children With Malignant Brain Tumors NCT06624371 | Emory University | Phase 1 |
| Recruiting | Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline NCT06779487 | Tata Memorial Centre | — |
| Not Yet Recruiting | Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models NCT06822842 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Not Yet Recruiting | Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and NCT06485908 | Assistance Publique Hopitaux De Marseille | Phase 1 / Phase 2 |
| Recruiting | Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for NCT06607692 | Fundación de investigación HM | Phase 1 / Phase 2 |
| Not Yet Recruiting | In Vitro Models From Pediatric Brain Tumors NCT06499636 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma NCT06396481 | Beijing Tiantan Hospital | EARLY_Phase 1 |
| Enrolling By Invitation | Intraoperatively Observed Site of Origin and Growth Pattern of Medulloblastoma NCT06814353 | Christian Dorfer | — |
| Recruiting | PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications NCT06161519 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Suspended | Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumo NCT05934630 | Pediatric Brain Tumor Consortium | — |
| Recruiting | Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors NCT05835687 | St. Jude Children's Research Hospital | Phase 1 |
| Recruiting | Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China NCT05672043 | Beijing Tiantan Hospital | — |
| Recruiting | Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblasto NCT05535166 | St. Jude Children's Research Hospital | Phase 2 |
| Recruiting | Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors NCT05278208 | Nationwide Children's Hospital | Phase 1 / Phase 2 |
| Terminated | Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma NCT04402073 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 2 |
| Active Not Recruiting | Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study NCT05128903 | St. Jude Children's Research Hospital | Phase 2 |
| Active Not Recruiting | A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma an NCT04978727 | Children's Oncology Group | Phase 1 |
| Recruiting | Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma NCT05057702 | University of California, San Francisco | N/A |
| Recruiting | Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer NCT05106296 | Theodore S. Johnson | Phase 1 |
| Recruiting | Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Sol NCT04337177 | Valent Technologies, LLC | Phase 1 |
| Terminated | A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and You NCT04730349 | Bristol-Myers Squibb | Phase 1 / Phase 2 |
| Recruiting | DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma NCT04696029 | Giselle Sholler | Phase 2 |
| Active Not Recruiting | Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, NCT04661384 | City of Hope Medical Center | Phase 1 |
| Unknown | NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors NCT05131763 | Fudan University | Phase 1 |
| Withdrawn | Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer NCT04521946 | M.D. Anderson Cancer Center | Phase 1 |
| Recruiting | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms NCT04541082 | Jazz Pharmaceuticals | Phase 1 |
| Unknown | Efficacy of Dual Task Training on Children With Ataxia After Medulloblastoma Resection NCT05125666 | Cairo University | Phase 2 |
| Completed | WP1066 in Children With Refractory and Progressive or Recurrent Malignant Brain Tumors NCT04334863 | Emory University | Phase 1 |
| Completed | Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults with Recurrent Medulloblast NCT04315064 | The University of Texas Health Science Center, Houston | EARLY_Phase 1 |
| Withdrawn | NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors NCT04270461 | Jiujiang University Affiliated Hospital | Phase 1 |
| Active Not Recruiting | Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG NCT04049669 | Theodore S. Johnson | Phase 2 |
| Recruiting | 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. NCT04081701 | Weill Medical College of Cornell University | Phase 4 |
| Withdrawn | StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain o NCT03990597 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescen NCT04023669 | St. Jude Children's Research Hospital | Phase 1 |
| Terminated | Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not H NCT03904862 | Pediatric Brain Tumor Consortium | Phase 1 / Phase 2 |
| Active Not Recruiting | Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors NCT03709680 | Pfizer | Phase 2 |
| Completed | EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS NCT03638167 | Seattle Children's Hospital | Phase 1 |
| Unknown | A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors NCT03734913 | Guangdong Zhongsheng Pharmaceutical Co., Ltd. | Phase 1 |
| Active Not Recruiting | HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumor NCT03500991 | Seattle Children's Hospital | Phase 1 |
| Active Not Recruiting | DOTATOC PET/CT for Imaging NET Patients NCT03583528 | British Columbia Cancer Agency | — |
| Completed | SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies fo NCT03434262 | St. Jude Children's Research Hospital | Phase 1 |
| Active Not Recruiting | Phase I Study of APX005M in Pediatric Central Nervous System Tumors NCT03389802 | Pediatric Brain Tumor Consortium | Phase 1 |
| Unknown | Study of Tomotherapy HD in Medulloblastoma NCT03675230 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | N/A |
| Active Not Recruiting | Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT- NCT02724579 | Children's Oncology Group | Phase 2 |
| Completed | Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children NCT03043391 | Istari Oncology, Inc. | Phase 1 |
| Completed | Dosimetry-Guided, Peptide Receptor Radiotherapy (PRRT) With 90Y-DOTA- tyr3-Octreotide (90Y-DOTATOC) NCT03273712 | University of Iowa | Phase 2 |
| Completed | A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain NCT03257631 | Celgene | Phase 2 |
| Completed | Rare CNS Tumors Outcomes &Risk NCT03251989 | National Cancer Institute (NCI) | — |
| Completed | Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers NCT03173950 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblasto NCT02212574 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | EARLY_Phase 1 |
| Withdrawn | Dosimetry Guided PRRT With 90Y-DOTATOC NCT03013387 | Sue O'Dorisio | Phase 2 |
| Withdrawn | Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors NCT02689336 | Washington University School of Medicine | Phase 2 |
| Terminated | Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) NCT02624388 | University of Virginia | Phase 2 |
| Completed | Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma NCT02747576 | St. Jude Children's Research Hospital | — |
| Completed | Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors NCT02644291 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 1 |
| Completed | Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primar NCT02502708 | NewLink Genetics Corporation | Phase 1 |
| Active Not Recruiting | HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors NCT02875314 | Parth Patel | Phase 4 |
| Completed | Impact of Ga-68 DOTATOC PET-CT Imaging in Management of Neuroendocrine Tumors NCT02441062 | Sue O'Dorisio | Phase 2 |
| Terminated | Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CN NCT02332889 | University of Louisville | Phase 1 / Phase 2 |
| Completed | Molecular-Guided Therapy for Childhood Cancer NCT02162732 | Giselle Sholler | N/A |
| Completed | Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medull NCT02017964 | Children's Oncology Group | Phase 2 |
| Completed | p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors NCT01975116 | Pediatric Brain Tumor Consortium | Phase 1 |
| Active Not Recruiting | A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma NCT01878617 | St. Jude Children's Research Hospital | Phase 2 |
| Completed | A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB NCT01708174 | Novartis Pharmaceuticals | Phase 2 |
| Withdrawn | Valproic Acid in Childhood Progressive Brain Tumors NCT01861990 | Medical University of South Carolina | Phase 1 |
| Unknown | Interest of a Dose Decrease for Radiotherapy Associated With Chemotherapy for Treatment of Standard Risk Adult NCT01857453 | Central Hospital, Nancy, France | Phase 2 |
| Completed | Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer NCT01802567 | Giselle Sholler | N/A |
| Completed | Safety of 68Ga-DOTA-tyr3-Octreotide PET in Diagnosis of Solid Tumors NCT01619865 | Sue O'Dorisio | Phase 1 / Phase 2 |
| Terminated | Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma NCT01483820 | Giselle Sholler | Phase 1 / Phase 2 |
| Completed | Auto Transplant for High Risk or Relapsed Solid or CNS Tumors NCT01505569 | Masonic Cancer Center, University of Minnesota | N/A |
| Completed | Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors NCT01331135 | Emory University | Phase 1 |
| Completed | A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminar NCT01125800 | Novartis Pharmaceuticals | Phase 1 / Phase 2 |
| Completed | An East Asian Study of LDE225 NCT01208831 | Novartis Pharmaceuticals | Phase 1 |
| Completed | Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor NCT01326104 | University of Florida | Phase 2 |
| Completed | Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor NCT01171469 | Masonic Cancer Center, University of Minnesota | Phase 1 |
| Completed | Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma NCT01063114 | Massachusetts General Hospital | N/A |
| Unknown | Radiation Therapy and Combination Chemotherapy for Medulloblastoma NCT02681705 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Phase 2 |
| Completed | A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With NCT00994071 | National Cancer Institute (NCI) | Phase 1 |
| Active Not Recruiting | Methionine PET/CT Studies In Patients With Cancer NCT00840047 | St. Jude Children's Research Hospital | Phase 2 |
| Unknown | Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CN NCT00983398 | OHSU Knight Cancer Institute | Phase 1 / Phase 2 |
| Completed | TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma NCT00867568 | Giselle Sholler | Phase 1 |
| Completed | Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors NCT00880308 | Novartis Pharmaceuticals | Phase 1 |
| Completed | Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of t NCT00867178 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults NCT01614132 | University of Regensburg | Phase 1 / Phase 2 |
| Completed | Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma NCT00601003 | Giselle Sholler | Phase 2 |
| Completed | Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Dia NCT00336024 | Children's Oncology Group | Phase 3 |
| Completed | A Study of Pemetrexed in Children With Recurrent Cancer NCT00520936 | Eli Lilly and Company | Phase 2 |
| Active Not Recruiting | Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High NCT00392327 | Children's Oncology Group | Phase 3 |
| Completed | Combination of Irinotecan and Temozolomide in Children With Brain Tumors. NCT00404495 | Pfizer | Phase 2 |
| Completed | Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors NCT01445288 | National Cancer Institute (NCI) | — |
| Unknown | Immuno 1: Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Stem Cell Transplant NCT00231712 | Julius-Maximilians University | — |
| Completed | Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newl NCT00085735 | Children's Oncology Group | Phase 3 |
| Completed | Hyperfractionated Versus Conventionally Fractionated Radiotherapy in Standard Risk Medulloblastoma (PNET4) NCT01351870 | Institut Curie | Phase 3 |
| Unknown | High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood NCT00180791 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 2 |
| Terminated | Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblas NCT00031590 | Children's Hospital of Philadelphia | Phase 2 |
| Completed | A Pediatric Phase I Trial of RMP-7 and Carboplatin in Brain Tumors NCT00001502 | National Cancer Institute (NCI) | Phase 1 |
| Available | An Intermediate Expanded Use Trial of DFMO NCT03581240 | Giselle Sholler | — |
| Completed | Clinical Studies of Gemcitabine-Oxaliplatin NCT00407433 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 2 |