NCT01614132

Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults

Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults (NOA-07)

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of Regensburg · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether a combination of a radiochemotherapy (vincristin) and a following maintenance chemotherapy (vincristin, cisplatin and CCNU) in adult patients with medulloblastoma is tolerable.

Detailed description

As medulloblastoma in adult patients are very rare (1.1% of all brain tumors), adults are often treated in the scope of expanded access treatments or within pediatric studies; although, it is not known whether medulloblastomas act in the same way in adulthood and in childhood. This is the first study to investigate the significance of a combination of a radiochemotherapy (vincristin) and a following maintenance chemotherapy (vincristin, cisplatin and CCNU) in adult patients with medulloblastoma with the purpose to have a starting point for the development of chemotherapeutical protocols in adults.

Conditions

• Medulloblastoma

Interventions

Type	Name	Description
DRUG	maintenance chemotherapy (vincristin, cisplatin and CCNU)	maintenance chemotherapy of maximum of 8 cycles á 42 days
RADIATION	Radiotherapy	Radiotherapy of the partial brain

Timeline

• Start date: 2009-01-01
• Primary completion: 2018-10-01
• Completion: 2018-10-01
• First posted: 2012-06-07
• Last updated: 2020-03-31

Locations

15 sites across 1 country: Germany