| Recruiting | Dynamic Network Response to TMS Treatment NCT07422844 | Goethe University | — |
| Recruiting | Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD) NCT07111390 | NYU Langone Health | N/A |
| Recruiting | Dose-Finding Clinical Trial to Evaluate the Efficacy and Safety of LV232 Capsules in the Treatment of MDD NCT06828887 | Vigonvita Life Sciences | Phase 2 |
| Recruiting | NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acid NCT07439744 | National Science and Technology Council, Taiwan | N/A |
| Completed | Determine the Bioavailability of Selegiline TDS 6mg/24 Hours vs EMSAM in Healthy Subjects NCT06607744 | Corium Innovations, Inc. | — |
| Recruiting | Psilocybin rTMS for Treatment Resistant Depression NCT06132178 | University of Texas at Austin | Phase 2 |
| Recruiting | At-Home tDCS as Maintenance Therapy NCT07269964 | Technical University of Munich | N/A |
| Active Not Recruiting | Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder NCT06670040 | Children's Hospital Medical Center, Cincinnati | N/A |
| Enrolling By Invitation | Operation of Brain Stimulation Equipment Under Remote Viewing Effectiveness Registry NCT06512324 | Biomedical Discoveries and Neuroscientific Foundations LLC | — |
| Recruiting | Cancer Related Major Depression Treated With a Single Dose of Psilocybin NCT06319378 | Section for Affective Disorders; Northern Stockholm Psychiatry | Phase 2 |
| Unknown | pBFS Guided rTMS Over Different Targets for Treatment-Resistant Depression NCT06255561 | Changping Laboratory | N/A |
| Enrolling By Invitation | Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder NCT06572683 | University of California, Los Angeles | N/A |
| Recruiting | Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disor NCT06130371 | University Hospital Tuebingen | — |
| Unknown | Take-home Functional Electrical Stimulation for MDD NCT06261177 | Unity Health Toronto | N/A |
| Unknown | rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS NCT06095778 | Changping Laboratory | N/A |
| Unknown | pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression NCT05976009 | Changping Laboratory | N/A |
| Unknown | pBFS Guided VS "5-cm Rule" rTMS Over DLPFC for MDD NCT05964023 | Changping Laboratory | N/A |
| Unknown | pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression NCT05976022 | Changping Laboratory | N/A |
| Completed | A Retrospective Study to Evaluate NeuroStar® Advanced Therapy in Adolescents NCT06699940 | Neuronetics | — |
| Completed | Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder NCT05525390 | Stanford University | N/A |
| Completed | Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition (XanaCIDD) NCT05657691 | Actinogen Medical | Phase 2 |
| Completed | SAD/MAD of ABX-002-1902 Investigating the Safety, Pharmacokinetics/Pharmacodynamics of in Healthy Subjects NCT05528315 | Autobahn Therapeutics, Inc. | Phase 1 |
| Recruiting | Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome i NCT05437588 | University of Alabama at Birmingham | N/A |
| Recruiting | Efficacy of Statins Among Major Depressive Disorder NCT06698666 | Ain Shams University | Phase 3 |
| Completed | Individualized Neuromodulation for Anhedonic Depression NCT05537285 | University of California, San Diego | N/A |
| Completed | Neurofeedback to Treat Depression NCT05169346 | University of Pennsylvania | N/A |
| Completed | The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of M NCT04279522 | Neurolief Ltd. | N/A |
| Completed | Mechanism of Action of tACS for the Treatment of MDD NCT03994081 | University of North Carolina, Chapel Hill | N/A |
| Completed | Effect of Magnesium Supplementation in Selective Serotonin Reuptake Inhibitors Treated Major Depressive Disord NCT04880460 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Phase 2 |
| Completed | Virtual Reality Behavioral Activation: An Intervention for Major Depressive Disorder NCT04268316 | Stanford University | N/A |
| Completed | Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder NCT04226352 | Johns Hopkins University | Phase 1 |
| Completed | Vortioxetine in Patients With Depression Coexisting With General Anxiety Disorder (GAD) NCT04220996 | H. Lundbeck A/S | Phase 4 |
| Completed | Effect of Zinc Supplementation on Depression in SSRI-treated Major Depressive Disorder Patients NCT04482296 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | N/A |
| Unknown | Effect of Short-Term Mindfulness-Based Training For Major Depression Disorder: An Eye-Tracking Study NCT04071886 | Central South University | N/A |
| Completed | Maintenance Transcranial Magnetic Stimulation in Major Depressive Disorder NCT04076644 | University of Missouri-Columbia | N/A |
| Terminated | Combined Treatment of Prolonged Exposure and Pramipexole for Posttraumatic Stress Disorder and Depression NCT03765138 | Research Foundation for Mental Hygiene, Inc. | Phase 3 |
| Unknown | Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder NCT03754712 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | N/A |
| Completed | Effect of Bupropion on Seizure Threshold in Depressed Patients NCT03126682 | Duke University | Phase 4 |
| Unknown | A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With Systemic ALK NCT03971305 | Sun Yat-sen University | — |
| Withdrawn | Implementation of a Self-Help Depression Program Among Orthopedic Patients NCT03083340 | University of Texas at Austin | N/A |
| Unknown | A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treat NCT02669030 | Institute for Advanced Medical Research, Alpharetta, GA | Phase 4 |
| Completed | Transcranial Alternating Current Stimulation for Major Depressive Disorder NCT02339285 | University of North Carolina, Chapel Hill | N/A |
| Completed | Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressi NCT02013609 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | Senior Peer Alliance for Rural Research On Wellness NCT01913366 | University of California, San Francisco | N/A |
| Completed | Can Mental Health Apps Work in the Real World? A Feasibility Pilot Study. NCT01808976 | University of California, San Francisco | N/A |
| Completed | Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression NCT01557946 | Mclean Hospital | Phase 4 |
| Completed | A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major NCT01344733 | AstraZeneca | — |
| Unknown | Evaluation of Generalization Paradigm Patterns Among Different Psychiatric Disorders NCT01501812 | Shalvata Mental Health Center | — |
| Completed | A Study to Assess the Long- Term Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Dis NCT01152554 | AstraZeneca | Phase 3 |