NCT07422844

Dynamic Network Response to TMS Treatment

Dynamic Network Changes During Transcranial Magnetic Stimulation Therapy in Depression

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Goethe University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This project aims to investigate whether symptom and brain networks and TMS stimulation sites can predict the response to TMS treatment of a transdiagnostic patient group with depressive syndrome. The TMS treatment is no intervention study - the investigators aim to observe patients who receive TMS as part of their psychiatric treatment. Additionally, the investigators aim to investigate exploratively how symptoms change over the course of treatment with TMS, that is, which symptoms respond first to treatment. Patients participate in a separate study first (DYNAMIC Central Project, registered with the German Clinical Trials Register: DRKS00038256), where MRI data is acquired. Within this project the symptomatology before, during and after the TMS-treatment are observed.

Conditions

• MDD

Timeline

• Start date: 2025-11-24
• Primary completion: 2031-12-31
• Completion: 2031-12-31
• First posted: 2026-02-20
• Last updated: 2026-02-20

Locations

1 site across 1 country: Germany